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Ligand N-hexanoyl-sphingenine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.138

ATP + N-hexanoyl-sphingenine = ADP + N-hexanoyl-sphingenine 1-phosphate

662592

-

3.5.1.23

N-caproylsphingosine + H2O = caproate + sphingosine

719011

-

3.5.1.23

N-hexanoylsphingosine + H2O = hexanoic acid + sphingosine

171992

-

3.5.1.23

2 entries

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.24

hexanoyl-CoA + sphingosine = CoA + N-hexanoylsphingosine

486668

-

2.3.1.24

sphingosine + hexanoyl-CoA = N-hexanoylsphingosine + CoA

0

-

2.3.1.24

2 entries

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.1.138

0.03

-

-

662592

References & Links

Literature References (4)

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Show Reference (4 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

171992

7744740

Purification, characterization, and biosynthesis of human acid ceramidase

1995

Bernardo, K.; Hurwitz, R.; Zenk, T.; Desnick, R.J.; Ferlinz, K.; Schuchman, E.H.; Sandhoff, K.

J. Biol. Chem.

270

11098-11102

486668

9655376

Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction

1998

Shimeno, H.; Soeda, S.; Sakamoto, M.; Kouchi, T.; Kowakame, T.; Kihara, T.

Lipids

33

601-605

662592

16269826

Further characterization of mammalian ceramide kinase. Substrate delivery and (stereo)specificity, tissue distribution and subcellular localization studies

2006

Van Overloop, H.; Gijsbers, S.; Van Veldhoven, P.P.

J. Lipid Res.

47

268-283

719011

21457750

Molecular cloning and characterization of neutral ceramidase homologue from the red flour beetle, Tribolium castaneum

2011

Zhou, Y.; Lin, X.W.; Yang, Q.; Zhang, Y.R.; Yuan, J.Q.; Lin, X.D.; Xu, R.; Cheng, J.; Mao, C.; Zhu, Z.R.

Biochimie

93

1124-1131

Links to other databases for N-hexanoyl-sphingenine

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Show Links (1 entry)

ChEBI

PubChem

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