Ligand D-sorbitol

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Basic Ligand Information

Molecular Structure
Picture of D-sorbitol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H14O6
D-sorbitol
FBPFZTCFMRRESA-FBXFSONDSA-N
Synonyms:
D-allitol, i-galactitol


Show all pahtways known for Show all BRENDA pathways known for D-sorbitol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-sorbitol + NAD+ = D-fructose + NADH + H+
show the reaction diagram
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D-sorbitol + NADP+ = L-sorbose + NADPH + H+
show the reaction diagram
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D-sorbitol + O2 = ?
show the reaction diagram
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D-sorbitol + O2 = ?
show the reaction diagram
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D-sorbitol + acceptor = L-sorbose + reduced acceptor
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-glucose + NADPH + H+ = D-sorbitol + NADP+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (51 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-sorbitol + NADH + H+ = L-gulose + NAD+
show the reaction diagram
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D-sorbitol + NAD+ = L-sorbose + NADH + H+
show the reaction diagram
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D-sorbitol + NAD+ = D-fructose + NADH + H+
show the reaction diagram
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D-sorbitol + NADP+ = ? + NADPH
show the reaction diagram
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i-galactitol + NAD+ = L-galactose + NADH
show the reaction diagram
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D-sorbitol + NADP+ = L-sorbose + NADPH + H+
show the reaction diagram
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D-sorbitol + NAD+ = L-sorbose + NADH + H+
show the reaction diagram
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D-sorbitol + NAD+ = ?
show the reaction diagram
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D-sorbitol + NAD+ = ? + NADH
show the reaction diagram
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D-sorbitol + NADP+ = L-sorbose + NADPH + H+
show the reaction diagram
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D-sorbitol + ferricytochrome c = D-fructose + ferrocytochrome c
show the reaction diagram
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D-sorbitol + O2 = ?
show the reaction diagram
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D-sorbitol + 2,6-dichlorophenolindophenol = ? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
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D-sorbitol + pyrroloquinoline quinone = ?
show the reaction diagram
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D-sorbitol + 2,6-dichlorophenol indophenol = ?
show the reaction diagram
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D-sorbitol + acceptor = ?
show the reaction diagram
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sucrose + D-sorbitol = ?
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D-sorbitol + 1,5-anhydro-D-glucitol = ? + phosphate
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D-sorbitol + alpha-D-glucose 1-phosphate = ? + phosphate
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ATP + D-sorbitol = ADP + ?
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Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-fructose + NADH + H+ = D-sorbitol + NAD+
show the reaction diagram
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D-glucose + NADPH + H+ = D-sorbitol + NADP+
show the reaction diagram
-
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L-sorbose + NADPH = D-sorbitol + NADP+
show the reaction diagram
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D-fructose + NADH + H+ = D-sorbitol + NAD+
show the reaction diagram
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D-glucose + D-sorbitol 6-phosphate = D-glucose 6-phosphate + D-sorbitol
show the reaction diagram
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D-sorbitol 6-phosphate + H2O = D-sorbitol + phosphate
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D-sorbitol-6-phosphate + H2O = D-sorbitol + phosphate
show the reaction diagram
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4-O-alpha-D-glucopyranosyl-D-sorbitol + H2O = alpha-D-glucose + D-sorbitol
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
at high concentration
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Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
above 49 mM, substrate inhibition
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inhibitory at more than 10% (w/v)
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about 70% residual activity after 1 h incubation with 0.5 mM D-sorbitol at pH 8.5 and 25°C
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competitive
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competitive
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (27 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.0052
-
at pH 7.9 and 25°C
1.8
-
pH 7.0, 30°C, recombinant enzyme
3820
-
at pH 10.0 and 25°C
17
-
pH 7.5, 30°C
3820
-
pH 10.0, 25°C

KM Value (55 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
350
-
at pH 7.9 and 25°C
250
-
pH 7.0, 30°C, recombinant enzyme
399.5
-
in 50 mM sodium phosphate at pH 7.0 and 30°C
167
-
pH 10.0, 25°C
58.5
-
recombinant protein
57
-
pH 5.5, 30°C
38.9
-
at pH 10.0 and 25°C
20
-
-
1.4
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pH 7.5, 30°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
109
-
pH 6.8, 30°C

References & Links

Links to other databases for D-sorbitol

ChEBI
PubChem
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PubChem