print visible entries

print all entries

Ligand D-sorbitol

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

ascorbate metabolism, degradation of sugar alcohols

KEGG

ABC transporters, Diabetic cardiomyopathy, Fructose and mannose metabolism, Galactose metabolism, Phosphotransferase system (PTS)

MetaCyc

2-keto-L-gulonate biosynthesis, D-galactose degradation IV, D-sorbitol biosynthesis I, D-sorbitol degradation I, L-ascorbate biosynthesis III (D-sorbitol pathway), sorbitol biosynthesis II more

Show all BRENDA pathways known for D-sorbitol

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

top print hide

Show Natural Substrate (10 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.14

D-sorbitol + acceptor = L-sorbose + reduced acceptor

740006

-

1.1.1.14

D-sorbitol + NAD+ = D-fructose + NADH + H+

711357, 741366, 655289

-

1.1.1.14

D-sorbitol + NAD+ = L-sorbose + NADH + H+

654867, 655022, 657360, 656930

-

1.1.1.14

3 entries

1.1.1.15

D-sorbitol + NAD+ = D-fructose + NADH + H+

741366

-

1.1.1.289

D-sorbitol + NADP+ = L-sorbose + NADPH + H+

724644

-

1.1.3.4

D-sorbitol + O2 = ?

696297

-

1.1.3.41

D-sorbitol + O2 = ?

696297

-

1.1.99.12

D-sorbitol + acceptor = L-sorbose + reduced acceptor

740828

-

1.1.99.21

D-sorbitol + acceptor = L-sorbose + reduced acceptor

740006, 724595, 389912, 389913, 740961

-

1.1.99.21

D-sorbitol + NADP+ = L-sorbose + NADPH

741426

-

1.1.99.21

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

top print hide

Show Natural Product (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.21

D-glucose + NADPH + H+ = D-sorbitol + NADP+

0

-

1.1.99.28

D-glucose + D-fructose + H2O = D-glucono-1,5-lactone + D-sorbitol

0

-

1.1.99.28

D-glucose + D-fructose = D-glucono-1,5-lactone + D-sorbitol

0

-

1.1.99.28

2 entries

Substrate in Enzyme-catalyzed Reactions (53 results)

top print hide

Show Substrate (53 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.1

D-sorbitol + NADH + H+ = L-gulose + NAD+

745695

-

1.1.1.10

D-sorbitol + NADP+ = ?

285665

-

1.1.1.10

D-sorbitol + NADP+ = D-sorbose + NADPH + H+

721689

-

1.1.1.11

D-sorbitol + NAD+ = L-sorbose + NADH + H+

701082

-

1.1.1.11

D-sorbitol + NAD+ = sorbose + NADH + H+

760713

-

1.1.1.12

D-allitol + NAD+ = D-psicose + NADH

655480

-

1.1.1.12

D-sorbitol + NAD+ = ? + NADH + H+

696988

-

1.1.1.12

D-sorbitol + NAD+ = D-fructose + NADH + H+

655480, 696988, 711121, 761551

-

1.1.1.138

D-sorbitol + NADP+ = ?

739923

-

1.1.1.138

D-sorbitol + NADP+ = D-sorbose + NADPH + H+

285861, 285865

-

1.1.1.14

D-sorbitol + 2,6-dichlorophenolindophenol = L-sorbose + ?

655030

-

1.1.1.14

D-sorbitol + acceptor = L-sorbose + reduced acceptor

740006

-

1.1.1.14

D-sorbitol + NAD(P)+ = L-sorbose + NAD(P)H + H+

680957

-

1.1.1.14

D-sorbitol + NAD+ = ? + NADH + H+

712908

-

1.1.1.14

D-sorbitol + NAD+ = D-fructose + NADH + H+

668325, 285882, 285887, 711357, 285892, 285872, 285876, 285879, 285881, 686021, 285895, 285890, 285880, 285883, 285889, 285891, 285894, 684974, 689569, 285896, 285886, 741366, 285901, 285897, 285874, 285888, 285884, 285899, 670513, 655289

-

1.1.1.14

D-sorbitol + NAD+ = L-sorbose + NADH + H+

654867, 655022, 655030, 656694, 656930, 657360, 736022

-

1.1.1.10

2 entries

1.1.1.11

2 entries

1.1.1.12

3 entries

1.1.1.138

2 entries

1.1.1.14

6 entries

1.1.1.15

D-sorbitol + NAD+ = D-fructose + NADH + H+

741366

-

1.1.1.2

D-sorbitol + NADP+ = ? + NADPH

286165

-

1.1.1.255

i-galactitol + NAD+ = L-galactose + NADH

286399

-

1.1.1.287

D-sorbitol + NAD+ = sorbose + NADH + H+

701082

-

1.1.1.287

D-sorbitol + NADP+ = sorbose + NADPH + H+

658781

-

1.1.1.287

2 entries

1.1.1.289

D-sorbitol + NADP+ = L-sorbose + NADPH + H+

724644, 664343, 663570, 667018

-

1.1.1.56

D-sorbitol + NAD+ = L-sorbose + NADH + H+

287126, 287127

-

1.1.1.67

D-sorbitol + NAD+ = ?

287259

-

1.1.1.69

D-sorbitol + NAD+ = ? + NADH

654316

-

1.1.1.9

D-sorbitol + NAD+ = ? + NADH + H+

738728

-

1.1.1.9

D-sorbitol + NAD+ = D-fructose + NADH + H+

246414, 246419, 684974, 246426, 655053, 760272, 246422, 655221, 667227, 738728, 761551, 246420, 246417, 246421, 655092, 710975, 737866

-

1.1.1.9

D-sorbitol + NAD+ = L-sorbose + NADH + H+

722437, 742112, 742937

-

1.1.1.9

3 entries

1.1.1.B60

D-sorbitol + NADP+ = L-sorbose + NADPH + H+

741426, 763738

-

1.1.2.2

D-sorbitol + ferricytochrome c = D-fructose + ferrocytochrome c

389622, 389620, 389621

-

1.1.2.8

D-sorbitol + phenazine methosulfate = ? + reduced phenazine methosulfate

762829

-

1.1.3.4

D-sorbitol + O2 = ?

695424, 696297

-

1.1.3.41

D-sorbitol + O2 = ?

695424, 696297

-

1.1.3.41

D-sorbitol + O2 = ? + H2O2

724072

-

1.1.3.41

2 entries

1.1.5.5

D-sorbitol + 2,6-dichlorophenolindophenol = ? + reduced 2,6-dichlorophenolindophenol

741374

-

1.1.5.7

D-sorbitol + pyrroloquinoline quinone = ?

696803

-

1.1.5.B1

D-sorbitol + 2,6-dichlorophenol indophenol = ?

688870

-

1.1.99.12

D-sorbitol + 2,6-dichlorophenolindophenol = ?

287726

-

1.1.99.12

D-sorbitol + 2,6-dichlorophenolindophenol = L-sorbose + reduced 2,6-dichlorophenolindophenol

740005

-

1.1.99.12

D-sorbitol + acceptor = D-glucose + D-gluconic acid + L-sorbose + reduced acceptor

287728

-

1.1.99.12

D-sorbitol + acceptor = L-sorbose + reduced acceptor

740828

-

1.1.99.12

4 entries

1.1.99.13

D-sorbitol + acceptor = ?

389892

-

1.1.99.21

D-sorbitol + acceptor = L-sorbose + reduced acceptor

389913, 654267, 740006, 724595, 740961, 389912, 685690

-

1.1.99.21

D-sorbitol + NADP+ = L-sorbose + NADPH

741426

-

1.1.99.21

D-sorbitol + phenazine methosulfate = ?

684722

-

1.1.99.21

D-sorbitol + ubiquinone-2 = ?

684722

-

1.1.99.22

D-sorbitol + 2,6-dichlorophenolindophenol = ? + reduced 2,6-dichlorophenolindophenol

740188

-

1.1.99.22

D-sorbitol + 2,6-dichlorophenolindophenol = L-sorbose + reduced 2,6-dichlorophenolindophenol

760731

-

1.1.99.22

D-sorbitol + acceptor = L-sorbose + reduced acceptor

654267, 685690, 287791

-

1.1.99.21

4 entries

1.1.99.22

3 entries

2.4.1.10

sucrose + D-sorbitol = ?

488313, 488335

-

2.4.1.230

D-sorbitol + 1,5-anhydro-D-glucitol = ? + phosphate

758811

-

2.4.1.7

D-sorbitol + alpha-D-glucose 1-phosphate = ? + phosphate

657623

-

2.7.1.2

ATP + D-sorbitol = ADP + ?

759161

-

Product in Enzyme-catalyzed Reactions (12 results)

top print hide

Show Product (12 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.12

D-psicose + NADH = D-allitol + NAD+

0

-

1.1.1.12

D-fructose + NADH + H+ = D-sorbitol + NAD+

0

-

1.1.1.12

2 entries

1.1.1.14

D-fructose + NADH + H+ = D-sorbitol + NAD+

0

-

1.1.1.21

D-glucose + NADPH + H+ = D-sorbitol + NADP+

0

-

1.1.1.289

L-sorbose + NADPH + H+ = D-sorbitol + NADP+

0

-

1.1.1.9

D-fructose + NADH + H+ = D-sorbitol + NAD+

0

-

1.1.99.28

D-glucose + D-fructose + H2O = D-glucono-1,5-lactone + D-sorbitol

0

-

1.1.99.28

D-glucose + D-fructose = D-glucono-1,5-lactone + D-sorbitol

10900, 10901, 10903, 10904, 10906, 10907, 10908, 10909, 10910, 10911, 10912, 10913, 10914, 10915, 0, 10905, 10902

-

1.1.99.28

2 entries

2.7.1.61

D-glucose + D-sorbitol 6-phosphate = D-glucose 6-phosphate + D-sorbitol

0

-

3.1.3.50

D-sorbitol 6-phosphate + H2O = D-sorbitol + phosphate

0, 653560

-

3.1.3.58

D-sorbitol-6-phosphate + H2O = D-sorbitol + phosphate

646416

-

3.2.1.20

4-O-alpha-D-glucopyranosyl-D-sorbitol + H2O = alpha-D-glucose + D-sorbitol

0

-

Activator in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Activating Compound (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.14

at high concentration

655289

-

Inhibitor in Enzyme-catalyzed Reactions (9 results)

top print hide

Show Inhibitors (9 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.14

above 49 mM, substrate inhibition

285872

-

1.1.1.B60

inhibitory at more than 10% (w/v)

741426

-

1.7.3.3

about 70% residual activity after 1 h incubation with 0.5 mM D-sorbitol at pH 8.5 and 25°C

712197

-

4.2.1.8

competitive

5899, 5900

-

5.1.3.3

competitive

2369

-

5.3.1.5

-

2746, 2754, 2771

-

5.3.1.5

competitive

2731, 2751, 2759

-

5.3.1.5

competitive against D-glucose, D-xylose, and D-ribose. Co2+ and Mg2+ prevent inhibition

2735

-

5.3.1.5

mixed-type inhibition

2773

-

5.3.1.5

4 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (29 results)

top print hide

Show Turnover Number (29 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.1.1.1

0.0052

-

at pH 7.9 and 25°C

745695

1.1.1.10

1.8

-

pH 7.0, 30°C, recombinant enzyme

721689

1.1.1.11

19.7

-

-

701082

1.1.1.11

19.7

-

pH 8.5, 25°C

701082

1.1.1.12

3.7

-

pH 9, 30°C

711121

1.1.1.12

8.28

-

pH 7.0, 30°C, native enzyme

761551

1.1.1.12

13.48

-

wild-type, pH 9.6, 20°C

696988

1.1.1.12

13.88

-

mutant Y318F, pH 9.6, 20°C

696988

1.1.1.12

809

-

wild-type

696988

1.1.1.12

833

-

mutant Y318F

696988

1.1.1.14

0.71

-

wild-type, pH 10.0

686021

1.1.1.14

1.19

-

mutant E154C, pH 9.0, 25°C

684974

1.1.1.14

2

8

pH 9.0, 25°C

684974

1.1.1.14

161

-

wild-type, pH 9.0, 25°C

684974

1.1.1.14

506

-

-

655289

1.1.1.287

2.57

-

pH 8.5, 25°C

658781

1.1.1.287

19.7

-

pH 8.5, 25°C

701082

1.1.1.9

2

8

-

684974

1.1.1.9

8.28

-

at pH 7.0 and 30°C

738728

1.1.1.9

8.28

-

pH 7.0, 30°C, native enzyme

761551

1.1.1.9

114

-

25°C, pH 7.5, Tris-HCl

655221

1.1.1.9

528

-

35°C, pH 7.5, native enzyme

667227

1.1.1.11

2 entries

1.1.1.12

6 entries

1.1.1.14

5 entries

1.1.1.287

2 entries

1.1.1.9

5 entries

1.1.1.B60

3820

-

at pH 10.0 and 25°C

741426

1.1.3.4

17

-

pH 7.5, 30°C

695424

1.1.3.41

1.2

-

pH 7.5, 25°C, recombinant enzyme

724072

1.1.3.41

17

-

in 50 mM sodium phosphate buffer, at pH 7.5 and 30°C

695424

1.1.3.41

17

-

pH 7.5, 25°C, recombinant enzyme

724072

1.1.3.41

17

-

pH 7.5, 30°C

695424

1.1.3.41

4 entries

1.1.99.21

3820

-

pH 10.0, 25°C

741426

K_M Value (58 results)

top print hide

Show KM Value (58 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.1

350

-

at pH 7.9 and 25°C

745695

1.1.1.10

250

-

pH 7.0, 30°C, recombinant enzyme

721689

1.1.1.11

127.3

-

-

701082

1.1.1.11

127.3

-

pH 8.5, 25°C

701082

1.1.1.12

0.868

-

mutant Y318F, pH 9.6, 20°C

696988

1.1.1.12

4.12

-

wild-type, pH 9.6, 20°C

696988

1.1.1.12

4.122

-

wild-type

696988

1.1.1.12

4.868

-

mutant Y318F

696988

1.1.1.12

11.3

-

pH 8.6, 25°C

655480

1.1.1.12

21.2

-

pH 7.0, 30°C, native enzyme

761551

1.1.1.12

46

-

pH 8.6, 25°C

655480

1.1.1.12

483.5

-

pH 9, 30°C

711121

1.1.1.14

0.0032

-

-

668325

1.1.1.14

0.24

-

-

285883

1.1.1.14

0.28

-

-

285879

1.1.1.14

0.33

-

wild-type, pH 10.0

686021

1.1.1.14

0.35

-

-

285876

1.1.1.14

0.38

-

-

285872

1.1.1.14

1.1

-

-

285880

1.1.1.14

1.5

-

-

655289

1.1.1.14

2.39

-

37°C, pH 10.5

670513

1.1.1.14

3

-

pH 9.0, 25°C

684974

1.1.1.14

5

-

-

285897

1.1.1.14

9.8

-

-

285882

1.1.1.14

11

-

-

285887, 285896

1.1.1.14

18

-

-

285895

1.1.1.14

18

-

pH 6.0, 25°C, with 2,6-dichlorophenolindophenol as electron acceptor

655030

1.1.1.14

21

-

wild-type, pH 9.0, 25°C

684974

1.1.1.14

40.3

-

-

285888

1.1.1.14

86

-

-

285874

1.1.1.14

132

-

in the presence of NADP+ (pH 10.1)

680957

1.1.1.14

785

-

mutant E154C, pH 9.0, 25°C

684974

1.1.1.11

2 entries

1.1.1.12

8 entries

1.1.1.14

20 entries

1.1.1.21

399.5

-

in 50 mM sodium phosphate at pH 7.0 and 30°C

700796

1.1.1.287

125

-

pH 8.5, 25°C

658781

1.1.1.287

127.3

-

pH 8.5, 25°C

701082

1.1.1.287

2 entries

1.1.1.289

167

-

pH 10.0, 25°C

663570

1.1.1.67

58.5

-

recombinant protein

287259

1.1.1.69

57

-

pH 5.5, 30°C

654316

1.1.1.9

0.00492

-

pH 12.0, 30°C, recombinant enzyme

760272

1.1.1.9

0.16

-

-

246417

1.1.1.9

3

-

kcat/Km (sorbitol): 9500/Msec

684974

1.1.1.9

4

-

35°C, pH 7.5, native enzyme

667227

1.1.1.9

21.2

-

at pH 7.0 and 30°C

738728

1.1.1.9

21.2

-

pH 7.0, 30°C, native enzyme

761551

1.1.1.9

30

-

-

246421

1.1.1.9

31.5

-

at pH 7.0 and 30°C

737866

1.1.1.9

31.5

-

native enzyme, pH 9.0, 35°C

742112

1.1.1.9

9 entries

1.1.1.B60

38.9

-

at pH 10.0 and 25°C

741426

1.1.2.2

20

-

-

389621

1.1.3.4

1.4

-

pH 7.5, 30°C

695424

1.1.3.41

0.44

-

pH 7.5, 25°C, recombinant enzyme

724072

1.1.3.41

1.4

-

in 50 mM sodium phosphate buffer, at pH 7.5 and 30°C

695424

1.1.3.41

1.4

-

pH 7.5, 25°C, recombinant enzyme

724072

1.1.3.41

1.4

-

pH 7.5, 30°C

695424

1.1.99.21

16.8

-

ubiquinone-2 as electron acceptor

684722

1.1.99.21

23.2

-

phenazine methosulfate as electron acceptor

684722

1.1.99.21

30

-

-

389912, 389913

1.1.99.21

38.9

-

pH 10.0, 25°C

741426

1.1.3.41

4 entries

1.1.99.21

4 entries

K_i Value (1 result)

top print hide

Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.3.50

109

-

pH 6.8, 30°C

653560

References & Links

Literature References (144)

top print hide

Show Reference (144 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

2369

1092963

Mutarotase (aldose 1-epimerase) from kidney cortex

1975

Bailey, J.M.; Fishman, P.H.; Kusiak, J.W.; Mulhern, S.; Pentchev, P.G.

Methods Enzymol.

41

471-484

2731

-

Studies on the D-glucose-isomerizing enzyme from Bacillus coagulans, strain HN-68. Part V. Comparative study on the three activities of D-glucose, D-xylose and D-ribose isomerization of the crystalline enzyme

1970

Danno, G.

Agric. Biol. Chem.

34

1805-1814

2735

239628

Properties of D-xylose isomerase from Streptomyces albus

1975

Sanchez, S.; Smiley, K.L.

Appl. Microbiol.

29

745-750

2746

-

Catalytic properties of D-xylose isomerase from Streptomyces violaceoruber

1986

Callens, M.; Kersters-Hilderson, H.; van Opstal, O.; de Bruyne, C.K.

Enzyme Microb. Technol.

8

696-700

2751

-

Characterization of the purified extracellular D-xylose isomerase devoid of D-glucose isomerase from Chainia sp.

1990

Khire, J.M.; Lachke, A.H.; Srinivasan, M.C.; Vartak, H.G.

Appl. Biochem. Biotechnol.

23

41-52

2754

-

Isolation and characterization of a D-glucose/xylose isomerase from a new thermophilic strain Streptomyces sp. (PLC)

1995

Inyang, C.U.; Gebhart, U.; Obi, S.K.C.; Bisswanger, H.

Appl. Microbiol. Biotechnol.

43

632-638

2759

1567370

Mechanism of D-fructose isomerization by Arthrobacter D-xylose isomerase

1992

Rangarajan, M.; Hartley, B.S.

Biochem. J.

283

223-233

2771

2769749

Structures of D-xylose isomerase from Arthrobacter strain B3728 containing the inhibitor xylitol and D-sorbitol at 2.5 A and 2.3 A resolution, respectively

1989

Henrick, K.; Collyer, C.A.; Blow, D.M.

J. Mol. Biol.

208

129-157

2773

1854338

D-Xylose (D-glucose) isomerase from Arthrobacter strain N.R.R.L. B3728

1991

Smith, C.A.; Rangarajan, M.; Hartley, B.S.

Biochem. J.

277

255-261

5899

4581499

Purification et proprietes de la D-mannonate hydrolase d'Escherichia coli'

1973

Robert-Baudouy, J.M.; Stoeber, F.R.

Biochim. Biophys. Acta

309

473-485

5900

6759855

D-Mannonate and D-altronate dehydratases of Escherichia coli K12

1982

Robert-Baudouy, J.; Jimeno-Abendano, J.; Stoeber, F.

Methods Enzymol.

90

288-294

10900

3745122

Glucose-fructose oxidoreductase, a new enzyme isolated from Zymomonas mobilis that is responsible for sorbitol production

1986

Zachariou, M.; Scopes, R.K.

J. Bacteriol.

167

863-869

10901

1537789

Cloning, sequence analysis and expression of the structural gene encoding glucose-fructose oxidoreductase from Zymomonas mobilis

1992

Kanagasundaram, V.; Scopes, R.K.

J. Bacteriol.

174

1439-1447

10902

3356190

The kinetics of glucose-fructose oxidoreductase from Zymomonas mobilis

1988

Hardman, M.J.; Scopes, R.K.

Eur. J. Biochem.

173

203-209

10903

9490072

A multistep process is responsible for product-induced inactivation of glucose-fructose oxidoreductase from Zymomonas mobilis

1998

Furlinger, M.; Haltrich, D.; Kulbe, K.D.; Nidetzky, B.

Eur. J. Biochem.

251

955-963

10904

1572370

Changes in the fluorescence of bound nucleotide during the reaction catalysed by glucose-fructose oxidoreductase from Zymomonas mobilis

1992

Hardman, M.J.; Tsao, M.; Scopes, R.K.

Eur. J. Biochem.

205

715-720

10905

9148926

The substitution of a single amino acid residue (Ser-116->Asp) alters NADP-containing glucose-fructose oxidoreductase of Zymomonas mobilis into a glucose dehydrogenase with dual coenzyme specificity

1997

Wiegert, T.; Sahm, H.; Sprenger, G.A.

J. Biol. Chem.

272

13126-13133

10906

8472911

Glucose-fructose oxidoreductase, a periplasmic enzyme of Zymomonas mobilis, is active in its precursor form

1993

Loos, H.; Sahm, H.L.; Sprenger, G.A.

FEMS Microbiol. Lett.

107

293-298

10907

8661942

Export of the periplasmic NADP-containing glucose-fructose oxidoreductase of Zymomonas mobilis

1996

Wiegert, T.; Sahm, H.; Sprenger, G.A.

Arch. Microbiol.

166

32-41

10908

-

Inactivation of glucose-fructose oxidoreductase from Zymomonas mobilis during its catalytic action

1996

Furlinger, M.; Nidetzky, B.; Scopes, R.K.; Haltrich, D.; Kulbe, K.D.

Ann. N. Y. Acad. Sci.

799

752-756

10909

9685715

Control of the association state of tetrameric glucose-fructose oxidoreductase from Zymomonas mobilis as the rationale for stabilization of the enzyme in biochemical reactors

1998

Furlinger, M.; Satory, M.; Haltrich, D.; Kulbe, K.D.; Nidetzky, B.

J. Biochem.

124

280-286

10910

-

Die periplasmatische Glukose-Fruktose-Oxidoreduktase aus Zymomonas mobilis

1997

Sprenger, G.A.

BIOspektrum

3

52-53

10911

18576080

Simultaneous enzymatic synthesis of gluconic acid and sorbitol. Production, purification, and application of glucose-fructose oxidoreductase and gluconolactonase

1997

Nidetzky, B.; Furlinger, M.; Gollhofer, D.; Haug, I.; Haltrich, D.; Kulbe, K.D.

Appl. Biochem. Biotechnol.

63-65

173-188

10912

-

Efficient protection of glucose-fructose oxidoreductase from Zymomonas mobilis against irreversible inactivation during its catalytic action

1995

Gollhofer, D.; Nidetzky, B.; Fuerlinger, M.; Kulbe, K.D.

Enzyme Microb. Technol.

17

235-240

10913

9063452

Expression of the Zymomonas mobilis gfo gene or NADP-containing glucose:fructose oxidoreductase (GFOR) in Escherichia coli. Formation of enzymatically active preGFOR but lack of processing into a stable periplasmic protein

1997

Wiegert, T.; Sahm, H.; Sprenger, G.A.

Eur. J. Biochem.

224

107-112

10914

8994968

The structure of glucose-fructose oxidoreductase from Zymomonas mobilis: an osmoprotective periplasmic enzyme containing non-dissociable NADP

1996

Kingston, R.L.; Scopes, R.K.; Baker, E.N.

Structure

4

1413-1428

10915

7756998

Crystallization and preliminary X-ray analysis of glucose-fructose oxidoreductase from Zymomonas mobilis

1994

Ermler, L.H.; Sprenger, G.A.; Sahm, H.

Protein Sci.

3

2447-2449

246414

13654257

A sensitive and stereospecific enzymatic assay for xylulose

1959

Hickman, J.; Ashwell, G.

J. Biol. Chem.

234

758-761

246417

-

Purification and properties of xylitol dehydrogenase from the xylose-fermenting yeast Candida shehatae

1990

Yang, V.W.; Jeffries, T.W.

Appl. Biochem. Biotechnol.

26

197-206

246419

8339

Chirality of xylitol-oxidizing enzymes from mammalian liver

1976

Alizade, M.A.; Brendel, K.; Gaede, K.

FEBS Lett.

67

41-44

246420

3886639

Inducible xylitol dehydrogenases in enteric bacteria

1985

Doten, R.C.; Mortlock, R.P.

J. Bacteriol.

162

845-848

246421

-

Purification and properties of D-xylulose reductase from Pachysolen tannophilus

1986

Morimoto, S.; Matsuo, M.; Azuma, K.; Sinskey, A.J.

J. Ferment. Technol.

64

219-225

246422

8504864

Dual relationships of xylitol and alcohol dehydrogenases in families of two protein types

1993

Persson, B.; Hallborn, J.; Walfridsson, M.; Hahn-Haegerdal, B.; Keraenen, S.; Penttilae, M.; Joernvall, H.

FEBS Lett.

324

9-14

246426

10779871

Development of a xylitol biosensor composed of xylitol dehydrogenase and diaphorase

2000

Takamizawa, K.; Uchida, S.; Hatsu, M.; Suzuki, T.; Kawai, K.

Can. J. Microbiol.

46

350-357

285665

-

Isolation and characterization of two xylitol dehydrogenases from Aspergillus niger

1994

Witteveen, C.F.B.; Weber, F.; Busink, R.; Visser, J.

Microbiology

140

1679-1685

285861

7085559

Purification and characterization of mannitol dehydrogenase from Aspergillus parasiticus

1982

Niehaus, W.G.; Dilts, R.P.

J. Bacteriol.

151

243-250

285865

-

Purification and properties of mannitol dehydrogenase from Agaricus bisporus sporocarps

1978

Ruffner, H.P.; Rast, D.; Tobler, H.; Karesch, H.

Phytochemistry

17

865-868

285872

7144570

Sorbitol dehydrogenase from rat liver

1982

Leissing, N.; McGuinness, E.T.

Methods Enzymol.

89

135-140

285874

16660917

Detection and characterization of sorbitol dehydrogenase from apple callus tissue

1979

Negm, F.B.; Loescher, W.H.

Plant Physiol.

64

69-73

285876

667078

Rapid affinity purification and properties of rat liver sorbitol dehydrogenase

1978

Leissing, N.; Mc Guinness, E.T.

Biochim. Biophys. Acta

524

254-261

285879

16089

Partial purification and characterization of sorbitol dehydrogenase from rat brain

1977

Rehg, J.E.; Torack, R.M.

J. Neurochem.

28

655-660

285880

13914358

Polyol dehydrogenase

1962

Smith, M.G.

Biochem. J.

83

135-144

285881

13479132

Oxidation of polyhydric alcohols by the prostate gland and seminal vesicle

1957

Williams-Ashman, H.G.; Banks, J.; Wolfson, S.K.

Arch. Biochem. Biophys.

72

485-494

285882

-

Sorbitol metabolism in spermatozoa

1959

King, T.E.; Mann, T.

Proc. R. Soc. Lond. B Biol. Sci.

151

226-243

285883

-

Sorbitol dehydrogenase from horse liver: Purification, characterization and comparative properties

1981

Bailey, J.P.; Renz, C.; McGuinness, E.T.

Comp. Biochem. Physiol. B

69

909-914

285884

-

Purification and properties of the NAD+-xylitol-dehydrogenase from the yeast Pichia stipitis

1989

Rizzi, M.; Harwart, K.; Erlemann, P.; Bui-Thanh, N.A.; Dellweg, H.

J. Ferment. Bioeng.

67

20-24

285886

-

Sorbitol dehydrogenase from Pseudomonas sp.: Purification, characterization and application to quantitative determination of sorbitol

1991

Schneider, K.H.; Giffhorn, F.

Enzyme Microb. Technol.

13

332-337

285887

1460002

Sorbitol dehydrogenase from Bacillus subtilis, purification, characterization and gene cloning

1992

Ng, K.; Ye, R.; Wu, X.C.; Wong, S.L.

J. Biol. Chem.

267

24989-24994

285888

-

Purification and properties of NAD-dependent sorbitol dehydrogenase from apple fruit

1994

Yamaguchi, H.; Kanayama, Y.; Yamaki, S.

Plant Cell Physiol.

35

887-892

285889

8174565

Inhibition and activation studies on sheep liver sorbitol dehydrogenase

1994

Lindstad, R.I.; Hermansen, L.F.; McKinley-McKee, J.S.

Eur. J. Biochem.

221

847-854

285890

7551049

Polyol metabolism of Rhodobacter sphaeroides: biochemical characterization of a short-chain sorbitol dehydrogenase

1995

Schauder, S.; Schneider, K.H.; Giffhorn, F.

Microbiology

141

1857-1863

285891

8521856

Effect of pH on sheep liver sorbitol dehydrogenase steady-state kinetics

1995

Lindstad, R.I.; McKinley-McKee, J.S.

Eur. J. Biochem.

233

891-898

285892

9059643

Human sorbitol dehydrogenase - a secondary alcohol dehydrogenase with distinct pathophysiological roles, pH dependent kinetic studies

1996

Maret, W.

Adv. Exp. Med. Biol.

-

383-393

285894

8898899

Reversible inhibition of sheep liver sorbitol dehydrogenase by thiol compounds

1996

Lindstad, R.I.; McKinley-McKee, J.S.

Eur. J. Biochem.

241

142-148

285895

9143345

Sorbitol dehydrogenase from bovine lens: purification and properties

1997

Marini, I.; Bucchioni, L.; Borella, P.; Del Corso, A.; Mura, U.

Arch. Biochem. Biophys.

340

383-391

285896

27393263

Purification and properties of NAD+-dependent sorbitol dehydrogenase from Bacillus fructosus

1999

Takayuki, U.

Biosci. Biotechnol. Biochem.

63

573-574

285897

27389646

Crystallization and properties of NAD-dependent D-sorbitol dehydrogenase from Gluconobacter suboxydans IFO 3257

1999

Adachi, O.; Toyama, H.; Theeragool, G.; Lotong, N.; Matsushita, K.

Biosci. Biotechnol. Biochem.

63

1589-1595

285899

10963448

Purification and characterization of NAD+-dependent sorbitol dehydrogenase from Japanese pear fruit

2000

Oura, Y.; Yamada, K.; Shiratake, K.; Yamaki, S.

Phytochemistry

54

567-572

285901

-

Characterization of D-sorbitol dehydrogenase involved in D-sorbitol production of a methanol yeast, Candida boidinii (Kloeckera sp.) No. 2201

1988

Vongsuvanlert, V.; Tani, Y.

Agric. Biol. Chem.

52

419-426

286165

4402936

Triphosphopyridine nucleotide-linked aldehyde reductase I. Purification and properties of the enzyme from pig kidney cortex

1972

Bosron, W.F.; Prairie, R.L.

J. Biol. Chem.

217

4480-4485

286399

-

Substrate stereospecificity of the NAD-dependent mannitol dehydrogenase from celery

1996

Stoop, J.M.H.; Chilton, W.S.; Pharr, D.M.

Phytochemistry

43

1145-1150

287126

-

Purification and characterization of a ribitol dehydrogenase from Enterobacter agglomerans strain 221e

1995

Muniruzzaman, S.; Kunisha, Y.; Ichiraku K.; Izumori, K.

J. Ferment. Bioeng.

79

496-498

287127

11272814

Membrane-bound sugar alcohol dehydrogenase in acetic acid bacteria catalyzes L-ribulose formation and NAD-dependent ribitol dehydrogenase is independent of the oxidative fermentation

2001

Adachi, O.; Fuji, Y.; Ano, Y.; Moonmangmee, D.; Toyama, H.; Shinagawa, E.; Theeragool, G.; Lotong, N.; Matsushita, K.

Biosci. Biotechnol. Biochem.

65

115-125

287259

9274047

Mannitol dehydrogenase from Rhodobacter sphaeroides Si4: subcloning, overexpression in Escherichia coli and characterization of the recombinant enzyme

1997

Schafer, A.; Stein, M.A.; Schneider, K.H.; Giffhorn, F.

Appl. Microbiol. Biotechnol.

48

47-52

287726

5354025

Enzymatic studies on the oxidation of sugar and sugar alcohol. 8. Particle-bound L-sorbose dehydrogenase from Gluconobacter suboxydans

1969

Sato, K.; Yamada, Y.; Aida, K.; Uemura, T.

J. Biochem.

66

521-527

287728

27392874

Isolation and Characterization of a New Quinoprotein Dehydrogenase, L-Sorbose/L-Sorbosone Dehydrogenase.

1999

Asakura, A.; Hoshino, T.

Biosci. Biotechnol. Biochem.

63

46-53

287791

-

Solubilization, purification and properties of membrane-bound glycerol dehydrogenase from Gluconobacter industrius

1985

Ameyama, M.; Shinagawa, E.; Matsushita, K.; Adachi, O.

Agric. Biol. Chem.

49

1001-1010

389620

13373782

Polyol dehydrogenases. 2. The polyol dehydrogenases of acetobacter suboxydans and candida utilis

1956

Arcus, A.C.; Edson, N.L.

Biochem. J.

64

385-394

389621

-

Mannitol (cytochrome) dehydrogenase

1966

Edson, N.L.; Shaw, D.R.D.

Methods Enzymol.

9

147-149

389622

27393178

A novel type of D-mannitol dehydrogenase from Acetobacter xylinum: occurrence, purification, and basic properties

1997

Oikawa, T.; Nakai, J.; Tsukagawa, Y.; Soda, K.

Biosci. Biotechnol. Biochem.

61

1778-1782

389892

-

Purification und properties of 3-ketosucrose-forming enzyme from the cells of Agrobacterium tumefaciens

1967

Hayano, K.; Fukui, S.

J. Biol. Chem.

242

3665-3672

389912

-

Purification and characterization of D-sorbitol dehydrogenase from membrane of Gluconobacter suboxydans var. alpha

1982

Shinagawa, E.; Matsushita, K.; Adachi, O.; Ameyama, M.

Agric. Biol. Chem.

46

135-141

389913

-

D-Sorbitol dehydrogenase from Gluconobacter suboxydans, membrane-bound

1982

Shinagawa, E.; Ameyama, M.

Methods Enzymol.

89

141-145

488313

-

Characterization of levansucrase from Rahnella aquatilis JCM-1683

1992

Ohtsuka, K.; Hino, S.; Fukushima, T.; Ozawa, O.; Kanematsu, T.; Uchida, T.

Biosci. Biotechnol. Biochem.

56

1373-1377

488335

-

Properties of levansucrase from Bacillus circulans

1996

Perez Oseguera, M.A.; Guereca, L.; Lopez-Munguia, A.

Appl. Microbiol. Biotechnol.

45

465-471

646416

2993253

Characterization of a membrane-regulated sugar phosphate phosphohydrolase from Lactobacillus casei

1985

London, J.; Hausman, S.Z.; Thompson, J.

J. Bacteriol.

163

951-956

653560

-

Purification and characterization of sorbitol-6-phosphate phosphatase from apple leaves

2003

Zhou, R.; Cheng, L.; Wayne, R.

Plant Sci.

165

227-232

654267

12676670

5-Keto-D-gluconate production is catalyzed by a quinoprotein glycerol dehydrogenase, major polyol dehydrogenase, in Gluconobacter species

2003

Matsushita, K.; Fujii, Y.; Ano, Y.; Toyama, H.; Shinjoh, M.; Tomiyama, N.; Miyazaki, T.; Sugisawa, T.; Hoshino, T.; Adachi, O.

Appl. Environ. Microbiol.

69

1959-1966

654316

15060755

Cloning of a gluconate/polyol dehydrogenase gene from Gluconobacter suboxydans IFO 12528, characterisation of the enzyme and its use for the production of 5-ketogluconate in a recombinant Escherichia coli strain

2004

Salusjarvi, T.; Povelainen, M.; Hvorslev, N.; Eneyskaya, E.V.; Kulminskaya, A.A.; Shabalin, K.A.; Neustroev, K.N.; Kalkkinen, N.; Miasnikov, A.N.

Appl. Microbiol. Biotechnol.

65

306-314

654867

12686146

Membrane-bound D-sorbitol dehydrogenase of Gluconobacter suboxydans IFO 3255 - enzymatic and genetic characterization

2003

Hoshino, T.; Sugisawa, T.; Shinjoh, M.; Tomiyama, N.; Miyazaki, T.

Biochim. Biophys. Acta

1647

278-288

655022

12506966

Main polyol dehydrogenase of Gluconobacter suboxydans IFO 3255, membrane-bound D-sorbitol dehydrogenase, that needs product of upstream gene, sldB, for activity

2002

Shinjoh, M.; Tomiyama, N.; Miyazaki, T.; Hoshino, T.

Biosci. Biotechnol. Biochem.

66

2314-2322

655030

11866120

Purification and properties of membrane-bound D-sorbitol dehydrogenase from Gluconobacter suboxydans IFO 3255

2002

Sugisawa, T.; Hoshino, T.

Biosci. Biotechnol. Biochem.

66

57-64

655053

12723607

Cloning of the xylitol dehydrogenase gene from Gluconobacter oxydans and improved production of xylitol from D-arabitol

2003

Sugiyama, M.; Suzuki, S.; Tonouchi, N.; Yokozeki, K.

Biosci. Biotechnol. Biochem.

67

584-591

655092

100148847

Purification and characterisation of NAD+-dependent xylitol dehydrogenase from Fusarium oxysporum.

2002

Panagiotou, G.; Kekos, D.; Macris, B.J.; Christakopoulos, P.

Biotechnol. Lett.

24

2089-2092

655221

12604239

Characterization of recombinant xylitol dehydrogenase from Galactocandida mastotermitis expressed in Escherichia coli

2003

Nidetzky, B.; Helmer, H.; Klimacek, M.; Lunzer, R.; Mayer, G.

Chem. Biol. Interact.

143-144

533-542

655289

14965227

Sorbitol dehydrogenase: structure, function and ligand design

2004

El-Kabbani, O.; Darmanin, C.; Chung, R.P.

Curr. Med. Chem.

11

465-476

655480

15128296

The metabolic role and evolution of L-arabinitol 4-dehydrogenase of Hypocrea jecorina

2004

Pail, M.; Peterbauer, T.; Seiboth, B.; Hametner, C.; Druzhinina, I.; Kubicek, C.P.

Eur. J. Biochem.

271

1864-1872

656694

-

Gluconobacter NAD-dependent polyol dehydrogenase catalyzed production of D-sorbitol and D-mannitol with coenzyme regeneration

2003

Parmentier, S.; Arnaut, F.; Vandamme, E.J.

Meded. - Fac. Landbouwkd. Toegepaste Biol. Wet.

68

215-218

656930

-

Sorbitol dehydrogenase expression and activity during apple fruit set and early development

2004

Nosarszewski, M.; Clements, A.M.; Downie, A.B.; Archbold, D.D.

Physiol. Plant.

121

391-398

657360

12962626

X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase

2003

Pauly, T.A.; Ekstrom, J.L.; Beebe, D.A.; Chrunyk, B.; Cunningham, D.; Griffor, M.; Kamath, A.; Lee, S.E.; Madura, R.; McGuire, D.; Subashi, T.; Wasilko, D.; Watts, P.; Mylari, B.L.; Oates, P.J.; Adams, P.D.; Rath, V.L.

Structure

11

1071-1085

657623

14740189

Physico-chemical and transglucosylation properties of recombinant sucrose phosphorylase from Bifidobacterium adolescentis DSM20083

2004

van den Broek, L.A.; van Boxtel, E.L.; Kievit, R.P.; Verhoef, R.; Beldman, G.; Voragen, A.G.

Appl. Microbiol. Biotechnol.

65

219-227

658781

16165327

Molecular cloning and functional expression of D-arabitol dehydrogenase gene from Gluconobacter oxydans in Escherichia coli

2005

Cheng, H.; Jiang, N.; Shen, A.; Feng, Y.

FEMS Microbiol. Lett.

252

35-42

663570

-

Purification and properties of NADPH-linked L-sorbose reductase from Gluconobacter melanogenus N44-1

1991

Sugisawa, T.; Hoshino, T.; Fujiwara, A.

Agric. Biol. Chem.

55

2043-2049

664343

27373916

Crystallization and properties of NADPH-dependent L-sorbose reductase from Gluconobacter melanogenus IFO 3294

1999

Adachi, O.; Ano, Y.; Moonmangmee, D.; Shinagawa, E.; Toyama, H.; Theeragool, G.; Lotong, N.; Matsushita, K.

Biosci. Biotechnol. Biochem.

63

2137-2143

667018

16134116

Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization

2005

Greenberg, J.R.; Price, N.P.; Oliver, R.P.; Sherman, F.; Rustchenko, E.

Yeast

22

957-969

667227

15803389

Characterization of the AXDH gene and the encoded xylitol dehydrogenase from the dimorphic yeast Arxula adeninivorans

2005

Böer, E.; Wartmann, T.; Schmidt, S.; Bode, R.; Gellissen, G.; Kunze, G.

Antonie van Leeuwenhoek

87

233-243

668325

15649778

Steady-state kinetic properties of sorbitol dehydrogenase from chicken liver

2005

Karacaoglan, V.; Ozer, I.

Comp. Biochem. Physiol. B Biochem. Mol. Biol.

140

309-312

670513

16289145

Molecular evidence of sorbitol dehydrogenase in tomato, a non-Rosaceae plant

2005

Ohta, K.; Moriguchi, R.; Kanahama, K.; Yamaki, S.; Kanayama, Y.

Phytochemistry

66

2822-2828

680957

16232778

Cloning of a gene for D-sorbitol dehydrogenase from Gluconobacter oxydans G624 and expression of the gene in Pseudomonas putida IFO3738

2000

Shibata, T.; Ichikawa, C.; Matsuura, M.; Takata, Y.; Noguchi, Y.; Saito, Y.; Yamashita, M.

J. Biosci. Bioeng.

89

463-468

684722

18407824

A pyrroloquinoline quinine-dependent membrane-bound d-sorbitol dehydrogenase from Gluconobacter oxydans exhibits an ordered Bi Bi reaction mechanism

2008

Yang, X.P.; Wei, L.J.; Ye, J.B.; Yin, B.; Wei, D.Z.

Arch. Biochem. Biophys.

477

206-210

684974

17343568

Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-Cys forms of yeast xylitol dehydrogenase

2007

Klimacek, M.; Hellmer, H.; Nidetzky, B.

Biochem. J.

404

421-429

685690

18323643

Distinct physiological roles of two membrane-bound dehydrogenases responsible for D-sorbitol oxidation in Gluconobacter frateurii

2008

Soemphol, W.; Adachi, O.; Matsushita, K.; Toyama, H.

Biosci. Biotechnol. Biochem.

72

842-850

686021

17952367

A hydrogen-bonding network in mammalian sorbitol dehydrogenase stabilizes the tetrameric state and is essential for the catalytic power

2007

Hellgren, M.; Kaiser, C.; de Haij, S.; Norberg, A.; Hoeoeg, J.O.

Cell. Mol. Life Sci.

64

3129-3138

688870

17259621

Identification of membrane-bound quinoprotein inositol dehydrogenase in Gluconobacter oxydans ATCC 621H

2007

Hoelscher, T.; Weinert-Sepalage, D.; Goerisch, H.

Microbiology

153

499-506

689569

18566893

Sugar levels modulate sorbitol dehydrogenase expression in maize

2008

de Sousa, S.M.; Paniago, M.D.; Arruda, P.; Yunes, J.A.

Plant Mol. Biol.

68

203-213

695424

-

Exploring the biocatalytic scope of alditol oxidase from Streptomyces coelicolor

2009

Van Hellemond, E.; Vermote, L.; Koolen, W.; Sonke, T.; Zandvoort, E.; Heuts, D.; Janssen, D.; Fraaije, M.

Adv. Synth. Catal.

351

1523-1530

696297

18154360

Structural analysis of the catalytic mechanism and stereoselectivity in Streptomyces coelicolor alditol oxidase

2008

Forneris, F.; Heuts, D.; Delvecchio, M.; Rovida, S.; Fraaije, M.; Mattevi, A.

Biochemistry

47

978-985

696803

11826975

Purification and characterization of membrane-bound quinoprotein cyclic alcohol dehydrogenase from Gluconobacter frateurii CHM 9

2001

Moonmangmee, D.; Fujii, Y.; Toyama, H.; Theeragool, G.; Lotong, N.; Matsushita, K.; Adachi, O.

Biosci. Biotechnol. Biochem.

65

2763-2772

696988

19674460

A single amino acid change (Y318F) in the L-arabitol dehydrogenase (LadA) from Aspergillus niger results in a significant increase in affinity for D-sorbitol

2009

Rutten, L.; Ribot, C.; Trejo-Aguilar, B.; Woesten, H.A.; de Vries, R.P.

BMC Microbiol.

9

166

700796

19056286

Structural and kinetic characterization of a maize aldose reductase

2009

de Sousa, S.M.; Rosselli, L.K.; Kiyota, E.; da Silva, J.C.; Souza, G.H.; Peroni, L.A.; Stach-Machado, D.R.; Eberlin, M.N.; Souza, A.P.; Koch, K.E.; Arruda, P.; Torriani, I.L.; Yunes, J.A.

Plant Physiol. Biochem.

47

98-104

701082

19629658

Cloning, purification and characterization of an NAD-dependent D-arabitol dehydrogenase from acetic acid bacterium, Acetobacter suboxydans

2009

Cheng, H.; Li, Z.; Jiang, N.; Deng, Z.

Protein J.

28

263-272

710975

20177886

Cloning and characterization of a thermostable xylitol dehydrogenase from Rhizobium etli CFN42

2010

Tiwari, M.K.; Moon, H.J.; Jeya, M.; Lee, J.K.

Appl. Microbiol. Biotechnol.

87

571-581

711121

20111899

Cloning, heterologous expression, and characterization of the xylitol and L-arabitol dehydrogenase genes, Texdh and Telad, from the thermophilic fungus Talaromyces emersonii

2010

Fernandes, S.; Tuohy, M.G.; Murray, P.G.

Biochem. Genet.

48

480-495

711357

18799757

Sorbitol can fuel mouse sperm motility and protein tyrosine phosphorylation via sorbitol dehydrogenase

2009

Cao, W.; Aghajanian, H.; Haig-Ladewig, L.; Gerton, G.

Biol. Reprod.

80

124-133

712197

19782743

Characterization, stabilization and activity of uricase loaded in lipid vesicles

2010

Tan, Q.Y.; Wang, N.; Yang, H.; Zhang, L.K.; Liu, S.; Chen, L.; Liu, J.; Zhang, L.; Hu, N.N.; Zhao, C.J.; Zhang, J.Q.

Int. J. Pharm.

384

165-172

712908

20220044

Pharmacokinetics, pharmacodynamics, tolerability, and safety of a novel sorbitol dehydrogenase inhibitor in healthy participants

2010

Landau, Z.; Novotny, M.J.; Preston, G.M.; Wright, K.; Freeman, T.; Dai, H.; Thompson, J.; Oates, P.J.; Calle, R.A.

J. Clin. Pharmacol.

50

521-530

721689

23506391

A novel L-xylulose reductase essential for L-arabinose catabolism in Trichoderma reesei

2013

Metz, B.; Mojzita, D.; Herold, S.; Kubicek, C.P.; Richard, P.; Seiboth, B.

Biochemistry

52

2453-2460

722437

-

Purification of xylitol dehydrogenase and improved production of xylitol by increasing XDH activity and NADH supply in Gluconobacter oxydans

2013

Zhang, J.; Li, S.; Xu, H.; Zhou, P.; Zhang, L.; Ouyang, P.

J. Agric. Food Chem.

61

2861-2867

724072

22231860

Hot or not? Discovery and characterization of a thermostable alditol oxidase from Acidothermus cellulolyticus 11B

2012

Winter, R.T.; Heuts, D.P.; Rijpkema, E.M.; van Bloois, E.; Wijma, H.J.; Fraaije, M.W.

Appl. Microbiol. Biotechnol.

95

389-403

724595

22878210

Characterization of genes involved in D-sorbitol oxidation in thermotolerant Gluconobacter frateurii

2012

Soemphol, W.; Saichana, N.; Yakushi, T.; Adachi, O.; Matsushita, K.; Toyama, H.

Biosci. Biotechnol. Biochem.

76

1497-1505

724644

22918792

Development of a substrate-coupled biocatalytic process driven by an NADPH-dependent sorbose reductase from Candida albicans for the asymmetric reduction of ethyl 4-chloro-3-oxobutanoate

2012

Cai, P.; An, M.; Xu, L.; Xu, S.; Hao, N.; Li, Y.; Guo, K.; Yan, M.

Biotechnol. Lett.

34

2223-2227

736022

22883556

Protein engineering of a thermostable polyol dehydrogenase

2012

Wulf, H.; Mallin, H.; Bornscheuer, U.

Enzyme Microb. Technol.

51

217-224

737866

25082263

Molecular analysis of NAD+-dependent xylitol dehydrogenase from the zygomycetous fungus Rhizomucor pusillus and reversal of the coenzyme preference

2014

Yamasaki-Yashiki, S.; Komeda, H.; Hoshino, K.; Asano, Y.

Biosci. Biotechnol. Biochem.

78

1943-1953

738728

27506274

Purification and characterization of xylitol dehydrogenase with L-arabitol dehydrogenase activity from the newly isolated pentose-fermenting yeast Meyerozyma caribbica 5XY2

2016

Sukpipat, W.; Komeda, H.; Prasertsan, P.; Asano, Y.

J. Biosci. Bioeng.

123

20-27

739923

27338577

Role of mannitol dehydrogenases in osmoprotection of Gluconobacter oxydans

2016

Zahid, N.; Deppenmeier, U.

Appl. Microbiol. Biotechnol.

100

9967-9978

740005

-

Overexpression of pyrroloquinoline quinone biosynthetic genes affects L-sorbose production in Gluconobacter oxydans WSH-003

2016

Wang, P.; Xia, Y.; Li, J.; Kang, Z.; Zhou, J.; Chen, J.

Biochem. Eng. J.

112

70-77

740006

-

Structural insights into the binding mode of D-sorbitol with sorbitol dehydrogenase using QM-polarized ligand docking and molecular dynamics simulations

2016

Selvaraj, C.; Krishnasamy, G.; Jagtap, S.; Patel, S.; Dhiman, S.; Kim, T.; Singh, S.; Lee, J.

Biochem. Eng. J.

114

244-256

740188

27849146

Membrane-bound glycerol dehydrogenase catalyzes oxidation of D-pentonates to 4-dehydro-D-pentonates, D-fructose to 5-dehydro-D-fructose, and D-psicose to 5-dehydro-D-psicose

2017

Ano, Y.; Hours, R.A.; Akakabe, Y.; Kataoka, N.; Yakushi, T.; Matsushita, K.; Adachi, O.

Biosci. Biotechnol. Biochem.

81

411-418

740828

25952118

Enhanced production of L-sorbose in an industrial Gluconobacter oxydans strain by identification of a strong promoter based on proteomics analysis

2015

Hu, Y.; Wan, H.; Li, J.; Zhou, J.

J. Ind. Microbiol. Biotechnol.

42

1039-1047

740961

25323199

Enhanced production of L-sorbose from D-sorbitol by improving the mRNA abundance of sorbitol dehydrogenase in Gluconobacter oxydans WSH-003

2014

Xu, S.; Wang, X.; Du, G.; Zhou, J.; Chen, J.

Microb. Cell Fact.

13

146

741366

24075932

Isolation, characterization and evaluation of the Pichia pastoris sorbitol dehydrogenase promoter for expression of heterologous proteins

2013

Periyasamy, S.; Govindappa, N.; Sreenivas, S.; Sastry, K.

Protein Expr. Purif.

92

128-133

741374

26440996

Crystal structure of quinone-dependent alcohol dehydrogenase from Pseudogluconobacter saccharoketogenes. A versatile dehydrogenase oxidizing alcohols and carbohydrates

2015

Rozeboom, H.J.; Yu, S.; Mikkelsen, R.; Nikolaev, I.; Mulder, H.J.; Dijkstra, B.W.

Protein Sci.

24

2044-2054

741426

27633501

A highly efficient sorbitol dehydrogenase from Gluconobacter oxydans G624 and improvement of its stability through immobilization

2016

Kim, T.S.; Patel, S.K.; Selvaraj, C.; Jung, W.S.; Pan, C.H.; Kang, Y.C.; Lee, J.K.

Sci. Rep.

6

33438

742112

25082263

Molecular analysis of NAD+-dependent xylitol dehydrogenase from the zygomycetous fungus Rhizomucor pusillus and reversal of the coenzyme preference

2014

Yamasaki-Yashiki, S.; Komeda, H.; Hoshino, K.; Asano, Y.

Biosci. Biotechnol. Biochem.

78

1943-1953

742937

26975753

Enhanced xylitol production expression of xylitol dehydrogenase from Gluconobacter oxydans and mixed culture of resting cell

2016

Qi, X.H.; Zhu, J.F.; Yun, J.H.; Lin, J.; Qi, Y.L.; Guo, Q.; Xu, H.

J. Biosci. Bioeng.

122

257-262

745695

29697194

Substrate scope of a dehydrogenase from Sphingomonas species A1 and its potential application in the synthesis of rare sugars and sugar derivatives

2018

Beer, B.; Pick, A.; Doering, M.; Lommes, P.; Sieber, V.

Microb. Biotechnol.

11

747-758

758811

29684280

Discovery of a kojibiose phosphorylase in Escherichia coli K-12

2018

Mukherjee, K.; Narindoshvili, T.; Raushel, F.M.

Biochemistry

57

2857-2867

759161

29275440

Enhancement of gene expression in Escherichia coli and characterization of highly stable ATP-dependent glucokinase from Pyrobaculum calidifontis

2018

Bibi, T.; Ali, M.; Rashid, N.; Muhammad, M.A.; Akhtar, M.

Extremophiles

22

247-257

760272

31552350

Identification of NAD-dependent xylitol dehydrogenase from Gluconobacter oxydans WSH-003

2019

Liu, L.; Zeng, W.; Du, G.; Chen, J.; Zhou, J.

ACS omega

4

15074-15080

760713

28364633

Improved xylitol production by expressing a novel D-arabitol dehydrogenase from isolated Gluconobacter sp. JX-05 and co-biotransformation of whole cells

2017

Qi, X.; Zhang, H.; Magocha, T.A.; An, Y.; Yun, J.; Yang, M.; Xue, Y.; Liang, S.; Sun, W.; Cao, Z.

Biores. Technol.

235

50-58

760731

27849146

Membrane-bound glycerol dehydrogenase catalyzes oxidation of D-pentonates to 4-keto-D-pentonates, D-fructose to 5-keto-D-fructose, and D-psicose to 5-keto-D-psicose

2017

Ano, Y.; Hours, R.; Akakabe, Y.; Kataoka, N.; Yakushi, T.; Matsushita, K.; Adachi, O.

Biosci. Biotechnol. Biochem.

81

411-418

761551

27506274

Purification and characterization of xylitol dehydrogenase with L-arabitol dehydrogenase activity from the newly isolated pentose-fermenting yeast Meyerozyma caribbica 5XY2

2017

Sukpipat, W.; Komeda, H.; Prasertsan, P.; Asano, Y.

J. Biosci. Bioeng.

123

20-27

762829

33686415

Characterization of a cryptic, pyrroloquinoline quinone-dependent dehydrogenase of Gluconobacter sp. strain CHM43

2021

Nguyen, T.; Naoki, K.; Kataoka, N.; Matsutani, M.; Ano, Y.; Adachi, O.; Matsushita, K.; Yakushi, T.

Biosci. Biotechnol. Biochem.

85

998-1004

763738

30692560

Overcoming NADPH product inhibition improves D-sorbitol conversion to L-sorbose

2019

Kim, T.S.; Gao, H.; Li, J.; Kalia, V.C.; Muthusamy, K.; Sohng, J.K.; Kim, I.W.; Lee, J.K.

Sci. Rep.

9

815

Links to other databases for D-sorbitol

top print hide

Show Links (1 entry)

ChEBI

PubChem

-