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L-phenylalanine + 6-methyl-tetrahydrobiopterin + O2 = L-tyrosine + 6-methyl-4-hydroxy-tetrahydrobiopterin
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L-phenylalanine + 6-methyl-tetrahydrobiopterin + O2 = L-tyrosine + 6-methyl-4a-hydroxy-tetrahydrobiopterin
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L-phenylalanine + 6-methyltetrahydrobiopterin + O2 = L-tyrosine + 6-methyl-4a-hydroxytetrahydrobiopterin
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L-tyrosine + 6-methyl-tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 6-methyl-4a-hydroxytetrahydrobiopterin
-
L-phenylalanine + 6-methyltetrahydrobiopterin + O2 = ?
-
L-tryptophan + 6-methyltetrahydrobiopterin + O2 = ?
-
L-tyrosine + 6-methyltetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 6-methyl-4a-hydroxytetrahydrobiopterin
-
L-tryptophan + 6-methyl-tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 6-methyl-4a-hydroxytetrahydrobiopterin
-
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0.063
-
pH 7.0, 25°C, recombinant mutant DELTA 117PheH V379D
0.083
-
pH 7.0, 25°C, recombinant mutant DELTA 117PheH
0.43
-
pH 7.0, 25°C, mutant E330H
0.43
-
pH 7.0, 25°C, mutant H285E
0.43
-
pH 7.0, 25°C, wild-type enzyme
1.2
-
pH 7.0, 25°C, mutant H290Q
1.6
-
pH 7.0, 25°C, mutant E330Q
3.4
-
pH 7.0, 25°C, mutant H290E
6.9
-
pH 7.0, 25°C, mutant H285Q
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Insights into the catalytic mechanisms of phenylalanine and tryptophan hydroxylase from kinetic isotope effects on aromatic hydroxylation
2006
Pavon, J.A.; Fitzpatrick, P.F.
Biochemistry
45
11030-11037
Co-expression of different subunits of human phenylalanine hydroxylase: Evidence of negative interallelic complementation
2006
Leandro, J.; Nascimento, C.; Tavares de Almeida, I.; Leandro, P.
Biochim. Biophys. Acta
1762
544-550
Long-term modulation of tyrosine hydroxylase activity and expression by endothelin-1 and -3 in the rat anterior and posterior hypothalamus
2008
Perfume, G.; Nabhen, S.L.; Riquelme Barrera, K.; Otero, M.G.; Bianciotti, L.G.; Vatta, M.S.
Am. J. Physiol. Regul. Integr. Comp. Physiol.
294
R905-R914
Characterization of metal ligand mutants of phenylalanine hydroxylase: Insights into the plasticity of a 2-histidine-1-carboxylate triad
2008
Li, J.; Fitzpatrick, P.F.
Arch. Biochem. Biophys.
475
164-168
Tryptophan hydroxylase is modulated by L-type calcium channels in the rat pineal gland
2008
Barbosa, R.; Scialfa, J.H.; Terra, I.M.; Cipolla-Neto, J.; Simonneaux, V.; Afeche, S.C.
Life Sci.
82
529-535
Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase
2007
Peter, J.; Alenina, N.; Bader, M.; Walther, D.J.
Mol. Cell. Biochem.
295
205-215
Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons
2008
Chen, X.; Xu, L.; Radcliffe, P.; Sun, B.; Tank, A.W.
Mol. Pharmacol.
73
1816-1828
Short-term regulation of tyrosine hydroxylase activity and expression by endothelin-1 and endothelin-3 in the rat posterior hypothalamus
2007
Perfume, G.; Morgazo, C.; Nabhen, S.; Batistone, A.; Hope, S.I.; Bianciotti, L.G.; Vatta, M.S.
Regul. Pept.
142
69-77
Role of selenium compounds on tyrosine hydroxylase activity, adrenomedullin and total RNA levels in hearts of rats
2009
Talas, Z.S.; Ozdemir, I.; Gok, Y.; Ates, B.; Yilmaz, I.
Regul. Pept.
159
137-141
Mutagenesis of a specificity-determining residue in tyrosine hydroxylase establishes that the enzyme is a robust phenylalanine hydroxylase but a fragile tyrosine hydroxylase
2013
Daubner, S.C.; Avila, A.; Bailey, J.O.; Barrera, D.; Bermudez, J.Y.; Giles, D.H.; Khan, C.A.; Shaheen, N.; Thompson, J.W.; Vasquez, J.; Oxley, S.P.; Fitzpatrick, P.F.
Biochemistry
52
1446-1455
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