Ligand 7-methyl-DL-tryptophan

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Basic Ligand Information

Molecular Structure
Picture of 7-methyl-DL-tryptophan (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C12H14N2O2
7-methyl-DL-tryptophan
KBOZNJNHBBROHM-UHFFFAOYSA-N
Synonyms:
7-Methyl-DL-Trp, 7-methyltryptophan, DL-7-methyl-tryptophan, DL-7-Methyltryptophan

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DL-7-methyltryptophan + O2 = 3-methyl-N-formylkynurenine
show the reaction diagram
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7-methyl-DL-tryptophan + O2 = ?
show the reaction diagram
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7-methyltryptophan + 6-methyltetrahydropterin + O2 = 5-hydroxy-7-methyltryptophan + 6-methyldihydropterin + H2O
show the reaction diagram
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dimethylallyl diphosphate + DL-7-methyl-tryptophan = diphosphate + DL-1-(3'-dimethylallyl)-7-methyl-tryptophan
show the reaction diagram
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dimethylallyl diphosphate + 7-methyl-DL-tryptophan = diphosphate + 7-(3-methylbut-2-enyl)-DL-tryptophan + ?
show the reaction diagram
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ATP + 7-methyltryptophan + tRNATrp = AMP + diphosphate + 7-methyltryptophyl-tRNATrp
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-serine + 7-methylindole = 7-methyltryptophan + H2O
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, 36% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
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0.02 mM, 14% inhibition
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.315
-
-
0.1267
-
in 50 mM Tris/HCl (pH 7.5) with 5 mM CaCl2
0.4
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pH 7.5, 37°C, recombinant His-tagged 5-DMATS

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0375
-
-
0.129
-
in 50 mM Tris/HCl (pH 7.5) with 5 mM CaCl2
0.47
-
pH 7.5, 37°C, recombinant His-tagged 5-DMATS

References & Links

Links to other databases for 7-methyl-DL-tryptophan

ChEBI
PubChem
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PubChem