Ligand tRNAMet

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Basic Ligand Information

Molecular Structure
Picture of tRNAMet (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C28H37N11O21P3R
tRNAMet
Synonyms:
5'-dephospho-RNA (n-1 nucleotides), ribosomal RNA, rRNA, t-RNALeu, tRNA(Ala), tRNA(Arg), tRNA(Asn), tRNA(Asp), tRNA(Cys), tRNA(Gln), tRNA(Glu), tRNA(Gly), tRNA(His), tRNA(Ile), tRNA(Leu), tRNA(Lys), tRNA(lys)), tRNA(Met), tRNA(Phe), tRNA(Pro), tRNA(Ser), tRNA(Thr), tRNA(Trp), tRNA(Tyr), tRNA(Val), tRNA-CCA-3', tRNA-Gly, tRNA-His, tRNA-Leu, tRNA-Met, tRNA-N, tRNA-Phe, tRNA-Tyr, tRNA-Val, tRNA1Glu, tRNA1Gly, tRNA2Glu, tRNA2Gly, tRNAAla, tRNAArg, tRNAAsn, tRNAAsp, tRNAAsx, tRNACys, tRNAGln, tRNAGlu, tRNAGlx, tRNAGly, tRNAguanine, tRNAHis, tRNAHisII, tRNAIle, tRNALys, tRNAPhe, tRNAPro, tRNAPyl, tRNAqueuine, tRNA queuine, tRNASer, tRNAThr, tRNATrp, tRNATyr, tRNAVal


Show all pahtways known for Show all BRENDA pathways known for tRNAMet

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (81 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-glutamate 1-semialdehyde + NADP+ + tRNAGlu = L-glutamyl-tRNAGlu + NADPH + H+
show the reaction diagram
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tRNAHis + S-adenosyl-L-methionine = methylated tRNAHis + S-adenosyl-L-homocysteine
show the reaction diagram
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ATP + Asp + tRNAAsn = AMP + diphosphate + L-aspartyl-tRNAAsn
show the reaction diagram
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ATP + glycine + tRNAGly = AMP + diphosphate + L-glycyl-tRNAGly
show the reaction diagram
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rRNA + H2O = ?
show the reaction diagram
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ATP + L-cysteine + tRNACys = AMP + diphosphate + L-cysteinyl-tRNACys
show the reaction diagram
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ATP + L-asparagine + tRNAAsn = AMP + diphosphate + L-asparaginyl-tRNAAsn
show the reaction diagram
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ATP + L-pyrrolysine + tRNAPyl = AMP + diphosphate + L-pyrrolysyl-tRNAPyl
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ATP + L-leucine + tRNAIle = AMP + diphosphate + L-leucyl-tRNALeu
show the reaction diagram
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ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle
show the reaction diagram
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ATP + L-valine + tRNAVal = AMP + diphosphate + L-valyl-tRNAVal
show the reaction diagram
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ATP + L-glutamate + tRNAAsp = AMP + diphosphate + L-glutamyl-tRNAAsp
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (64 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-glutamyl-tRNAGlu + NADPH + H+ = L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
show the reaction diagram
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L-alanyl-tRNAAla + phosphatidylglycerol = tRNAAla + 3-O-L-alanyl-1-O-phosphatidylglycerol
show the reaction diagram
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MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-tri-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + glycyl-tRNAGly = MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-penta-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + tRNAGly
show the reaction diagram
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ergosterol + L-aspartyl-tRNAAsn = ergosteryl-3beta-O-L-aspartate + tRNAAsn
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ergosterol + L-glycyl-tRNAGly = ergosteryl-3beta-O-glycine + tRNAGly
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (317 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-glutamate 1-semialdehyde + NADP+ + tRNAGlu = L-glutamyl-tRNAGlu + NADPH + H+
show the reaction diagram
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tRNAHis + S-adenosyl-L-methionine = methylated tRNAHis + S-adenosyl-L-homocysteine
show the reaction diagram
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ATP + Asp + tRNAAsn = AMP + diphosphate + L-aspartyl-tRNAAsn
show the reaction diagram
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ATP + glycine + tRNAGly = AMP + diphosphate + L-glycyl-tRNAGly
show the reaction diagram
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tRNAguanine + 7-cyano-7-deazaguanine = ?
show the reaction diagram
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S-adenosyl-L-methionine + tRNAPhe = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl) uridine
show the reaction diagram
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ATP + rRNA = diphosphate + ?
show the reaction diagram
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tRNACys + 2 CTP + ATP = tRNACys with 3'-CCA end + 3 diphosphate
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rRNA + H2O = ?
show the reaction diagram
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tRNATyr + H2O = ?
show the reaction diagram
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ribosomal RNA + H2O = smaller precursor rRNA
show the reaction diagram
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rRNA + H2O = ?
show the reaction diagram
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ATP + L-leucine + tRNAIle = AMP + diphosphate + L-leucyl-tRNALeu
show the reaction diagram
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ATP + L-glutamate + tRNAAsp = AMP + diphosphate + L-glutamyl-tRNAAsp
show the reaction diagram
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ATP + L-glutamate + tRNAGlu = AMP + diphosphate + L-glutamyl-tRNAGlu
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (163 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-alanyl-tRNAAla + phosphatidylglycerol = tRNAAla + 3-O-L-alanyl-1-O-phosphatidylglycerol
show the reaction diagram
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glycyl-tRNAGly + N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine = tRNAGly + N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine
show the reaction diagram
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MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-tri-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + glycyl-tRNAGly = MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-penta-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + tRNAGly
show the reaction diagram
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ergosterol + L-aspartyl-tRNAAsn = ergosteryl-3beta-O-L-aspartate + tRNAAsn
show the reaction diagram
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ergosterol + L-glycyl-tRNAGly = ergosteryl-3beta-O-glycine + tRNAGly
show the reaction diagram
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guanine + tRNAguanine = tRNAguanine + guanine
show the reaction diagram
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tRNAqueuine + guanine = tRNAguanine + queuine
show the reaction diagram
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pre-tRNAArg + H2O = tRNAArg + 3'-leader of tRNA
show the reaction diagram
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AMP + diphosphate + L-tyrosyl-tRNATyr = ATP + L-tyrosine + tRNATyr
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AMP + diphosphate + L-methionyl-tRNAMet = ATP + L-methionine + tRNAMet
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AMP + diphosphate + L-seryl-tRNASer = ATP + L-serine + tRNASer
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AMP + diphosphate + L-cysteinyl-tRNACys = ATP + L-cysteine + tRNACys
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AMP + diphosphate + L-threonyl-tRNAThr = ATP + L-threonine + tRNAThr
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Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates the ATPase activity of DbpA by promoting a conformational change after ATP binding that is associated with hydrolysis
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required by the nucleolar located enzyme
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Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits binding of 16S rRNA to RUMT
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tRNALys from Escherichia coli
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weak inhibitor of T4 mRNA-degradation
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specific competitive inhibition
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (383 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.19
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pH 7.2, 37°C, wild-type tRNAPyl
0.04
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pH 7.2, 37°C

KM Value (491 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE