Ligand 2-hydroxyvalerate

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Basic Ligand Information

Molecular Structure
Picture of 2-hydroxyvalerate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H10O3
2-hydroxyvalerate
JRHWHSJDIILJAT-UHFFFAOYSA-N
Synonyms:
(R,S)-2-hydroxyvalerate, 2-hydroxy-n-pentanoate, 2-hydroxypentanoate, 2-hydroxypentanoic acid, 2-hydroxyvaleric acid, alpha-hydroxyvaleric acid, DL-2-Hydroxypentanoate, DL-2-hydroxyvalerate, DL-alpha-hydroxy-n-valerate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DL-2-hydroxyvalerate + O2 = 2-oxovalerate + H2O2
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-hydroxyvalerate + NAD+ = 2-oxovalerate + NADH + H+
show the reaction diagram
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2-hydroxypentanoate + NAD+ = 2-oxopentanoate + NADH + H+
show the reaction diagram
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2-hydroxypentanoate + O2 = 2-oxopentanoate + H2O2
show the reaction diagram
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2-hydroxy-n-pentanoate + NADH = 2-oxo-n-pentanoate + NADH
show the reaction diagram
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2-hydroxyvalerate + O2 = ?
show the reaction diagram
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alpha-hydroxyvaleric acid + H2O + O2 = 2-oxopentanoic acid + NH3 + H2O2
show the reaction diagram
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DL-2-hydroxypentanoate + acetoacetyl-CoA = 2-hydroxypentanoyl-CoA + acetoacetate
show the reaction diagram
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ATP + D-Ala + 2-hydroxypentanoate = ADP + phosphate + D-Ala-D-2-hydroxypentanoate
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Product in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxopentanoate + NADH + H+ = 2-hydroxypentanoate + NAD+
show the reaction diagram
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2-oxoisovalerate + NADPH = 2-hydroxyvalerate + NADP+
show the reaction diagram
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2-oxovalerate + NADH + H+ = 2-hydroxyvalerate + NAD+
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2-oxopentanoate + NADH + H+ = 2-hydroxypentanoate + NAD+
show the reaction diagram
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1,2-pentanediol + O2 = 2-hydroxypentanoate + H2O2
show the reaction diagram
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1,2-pentanediol + O2 = 2-hydroxypentanoic acid + H2O2
show the reaction diagram
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valeric acid + 2-oxoglutarate + O2 = 2-hydroxyvaleric acid + succinate + CO2
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
10 mM, 67.4% inhibition
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marked inhibition above 50 mM
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
24
-
pH 7.0, temperature not specified in the publication

KM Value (16 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.8
-
pH 8.0, 30C
3.3
-
pH 7.0, temperature not specified in the publication
21
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pH 7.5, 25C
8.3
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References & Links

Links to other databases for 2-hydroxyvalerate

ChEBI
PubChem
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PubChem