Ligand cholesterol 3-sulfate

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Basic Ligand Information

Molecular Structure
Picture of cholesterol 3-sulfate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C27H46O4S
cholesterol 3-sulfate
GIDHEQISKWNHIO-UOMBLCTASA-N

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3'-phosphoadenylylsulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
show the reaction diagram
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3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cholesterol 3-sulfate + [reduced NADPH-hemoprotein reductase] + H+ + O2 = (24S)-24-hydroxycholesterol 3-sulfate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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cholesterol 3-sulfate + H2O = cholesterol + sulfate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3'-phosphoadenylylsulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
show the reaction diagram
-
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3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
i.e. CH-35
-
activates
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potent stimulator for the GSK-3beta-mediated phosphorylation of tau protein (about 10fold stimulation in the presence of 0.003 mM)
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for cholesterol 3-sulfate

ChEBI
PubChem
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PubChem