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Ligand glycerophosphoserine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.4.46

glycerophosphoserine + H2O = sn-glycerol 3-phosphate + serine

680514

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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.111

a 1-acyl-2-lyso-phosphatidylserine + H2O = glycerophosphoserine + a fatty acid

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Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.4.2

glycerophosphoserine + H2O = L-serine + glycerol 3-phosphate

646468

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3.1.4.2

glycerophosphoserine + H2O = serine + glycerol 3-phosphate

95138

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3.1.4.46

glycerophosphoserine + H2O = ?

646467, 680514

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3.1.4.46

glycerophosphoserine + H2O = sn-glycerol 3-phosphate + serine

680514

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3.1.4.2

2 entries

3.1.4.46

2 entries

Product in Enzyme-catalyzed Reactions (5 results)

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Show Product (5 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.111

1-oleoyl-2-lyso-phosphatidylserine + H2O = glycerophosphoserine + oleate

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3.1.1.111

1-oleoyl-sn-glycero-3-phophoserine + H2O = glycerophosphoserine + oleate

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3.1.1.111

a 1-acyl-2-lyso-phosphatidylserine + H2O = glycerophosphoserine + a fatty acid

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3.1.1.5

1-acyl-sn-glycero-3-phosphoserine + H2O = fatty acid + glycerophosphoserine

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3.1.1.5

1-palmitoyl-sn-glycero-3-phosphoserine + H2O = glycerophosphoserine + palmitic acid

649683,

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3.1.1.111

3 entries

3.1.1.5

2 entries

Activator in Enzyme-catalyzed Reactions (2 results)

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Show Activating Compound (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.4.21.6

i.e. GPS, binding constants in presence of Ca2+

650170

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7.6.2.1

prevents transport of phosphatidylserine

246839

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Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.1.4.44

blocks the hydrolysis of glycerophosphoinositol by 80%

653592

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Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (2 results)

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Show Turnover Number (2 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.1.4.46

2.8

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-

680514

3.1.4.46

2.8

-

UgpQ, 5 mM Mg2+, pH 7.4, 35°C

680514

3.1.4.46

2 entries

K_M Value (3 results)

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Show KM Value (3 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.4.2

0.59

-

-

95138

3.1.4.46

0.66

-

-

680514

3.1.4.46

0.66

-

5 mM Mg2+, pH 7.4, 35°C

680514

3.1.4.46

2 entries

References & Links

Literature References (8)

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Show Reference (8 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

95138

2829735

Purification and characterization of glpQ-encoded glycerophosphodiester phosphodiesterase from Escherichia coli K-12

1988

Larson, T.J.; van Loo-Bhattacharya, A.T.

Arch. Biochem. Biophys.

260

577-584

246839

10856717

Identification and purification of aminophospholipid flippases

2000

Daleke, D.L.; Lyles, J.V.

Biochim. Biophys. Acta

1486

108-127

646467

14750903

Identification and characterisation of plant glycerophosphodiester phosphodiesterase

2004

Van Der Rest, B.; Rolland, N.; Boisson, A.M.; Ferro, M.; Bligny, R.; Douce, R.

Biochem. J.

379

601-607

646468

12226504

Glycerophosphocholine metabolism in higher plant cells. Evidence of a new glyceryl-phosphodiester phosphodiesterase

2002

Van der Rest, B.; Boisson, A.M.; Gout, E.; Bligny, R.; Douce, R.

Plant Physiol.

130

244-255

649683

10749672

Purification and characterization of secretory phospholipase B, lysophospholipase and lysophospholipase/transacylase from a virulent strain of the pathogenic fungus Cryptococcus neoformans

2000

Chen, S.C.; Wright, L.C.; Golding, J.C.; Sorrell, T.C.

Biochem. J.

347

431-439

650170

12056907

Specificity of soluble phospholipid binding sites on human factor Xa

2002

Banerjee, M.; Drummond, D.C.; Srivastava, A.; Daleke, D.; Lentz, B.R.

Biochemistry

41

7751-7762

653592

12576545

GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors

2003

Zheng, B.; Berrie, C.P.; Corda, D.; Farquhar, M.G.

Proc. Natl. Acad. Sci. USA

100

1745-1750

680514

18083802

Escherichia coli cytosolic glycerophosphodiester phosphodiesterase (UgpQ) requires Mg2+, Co2+, or Mn2+ for its enzyme activity

2008

Ohshima, N.; Yamashita, S.; Takahashi, N.; Kuroishi, C.; Shiro, Y.; Takio, K.

J. Bacteriol.

190

1219-1223

Links to other databases for glycerophosphoserine

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Show Links (1 entry)

ChEBI

PubChem

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