Ligand thioglycerol

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Basic Ligand Information

Molecular Structure
Picture of thioglycerol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H8O2S
thioglycerol
PJUIMOJAAPLTRJ-UHFFFAOYSA-N
Synonyms:
1-mercapto-2,3-propanediol, 1-thioglycerol, 3-mercapto-1,2-propanediol, alpha-thioglycerol, alpha-thiolglycerol, mercaptopropanediol, monothioglycerol, monothiolglycerol

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-mercapto-1,2-propanediol + NAD+ = ?
show the reaction diagram
-
O-acetyl-L-homoserine + thioglycerol = ?
show the reaction diagram
-
L-Cysteine + monothioglycerol = ?
show the reaction diagram
-
thioglycerol = ?
show the reaction diagram
-
L-homoserine + thioglycerol = S-(2,3-dihydroxypropyl)-L-homocysteine
show the reaction diagram
-
3-chloro-D-alanine + alpha-thiolglycerol = S-(2,3-dihydroxypropyl)-D-cysteine
show the reaction diagram
-
3-chloro-L-alanine + 1-thioglycerol = S-2,3-dihydroxypropyl-L-cysteine + Cl-
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM is required for optimal activity
-
slight stimulation
-
stimulation
-
activates
-
activates, (Z)-phenylacetaldoxime dehydration, 1 mM, 4.06fold
-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive
-
holodiol dehydratase undergoes rapid and irreversible inactivation, the inactivation cleaves the Co-C bond of adenosylcobalamin irreversibly forming unidentified radicals and cob(II)alamin that resist oxidation even in the presence of oxygen, inactivation mechanism, overview
-

3D Structure of Enzyme-Ligand-Complex (PDB) (26 results)

Enzyme Kinetic Parameters

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
4
-
pH 8.8, 25C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.1
-
pH 8.0, 37C

References & Links

Links to other databases for thioglycerol

ChEBI
PubChem
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PubChem