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Basic Ligand Information
3H 8O 2S
1-mercapto-2,3-propanediol, 1-thioglycerol, 3-mercapto-1,2-propanediol, alpha-thioglycerol, alpha-thiolglycerol, mercaptopropanediol, monothioglycerol, monothiolglycerol
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (9 results)
3-mercapto-1,2-propanediol + NAD+ = ?
O-acetyl-L-homoserine + thioglycerol = ?
ATP + mercaptopropanediol = 1-mercaptopropanediol 1-phosphate + ADP
ATP + monothioglycerol = ADP + ?
L-Cysteine + monothioglycerol = ?
L-homoserine + thioglycerol = S-(2,3-dihydroxypropyl)-L-homocysteine
3-chloro-D-alanine + alpha-thiolglycerol = S-(2,3-dihydroxypropyl)-D-cysteine
3-chloro-L-alanine + 1-thioglycerol = S-2,3-dihydroxypropyl-L-cysteine + Cl-
- Activator in Enzyme-catalyzed Reactions (7 results)
1 mM is required for optimal activity
activity is stimulated 10fold by 25 mM
stimulates uterine and chorion enzymes by 5fold and 15fold
activates, (Z)-phenylacetaldoxime dehydration, 1 mM, 4.06fold
- Inhibitor in Enzyme-catalyzed Reactions (5 results)
binds weakly, shows high affinity to the mammalian HO
binds with 10fold lower affinity than DTT, shows high affinity to the mammalian HO
holodiol dehydratase undergoes rapid and irreversible inactivation, the inactivation cleaves the Co-C bond of adenosylcobalamin irreversibly forming unidentified radicals and cob(II)alamin that resist oxidation even in the presence of oxygen, inactivation mechanism, overview
- 3D Structure of Enzyme-Ligand-Complex (PDB) (26 results)
Enzyme Kinetic Parameters
M Value (3 results) K
i Value (1 result) References & Links
Links to other databases for thioglycerol