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Ligand nicotianamine

Basic Ligand Information

Molecular Structure

Related pathways

Show all BRENDA pathways known for nicotianamine

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.6.1.80

nicotianamine + 2-oxoglutarate = 3''-deamino-3''-oxonicotianamine + L-glutamate

659597, 660211, 659982, 760026

-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.5.1.43

3 S-adenosyl-L-methionine = 3 S-methyl-5'-thioadenosine + nicotianamine

-

-

2.5.1.43

S-adenosyl-L-methionine = 5'-S-methyl-5'-thioadenosine + nicotianamine

-

-

2.5.1.43

2 entries

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.6.1.80

nicotianamine + 2-oxoglutarate = 3''-deamino-3''-oxonicotianamine + L-glutamate

659597, 660211, 659982, 760026

-

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.5.1.43

3 S-adenosyl-L-methionine = 3 S-methyl-5'-thioadenosine + nicotianamine

-

-

2.5.1.43

S-adenosyl-L-methionine = 5'-S-methyl-5'-thioadenosine + nicotianamine

639735, 639733, 639734, 639736, -

-

2.5.1.43

2 entries

Inhibitor in Enzyme-catalyzed Reactions (3 results)

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Show Inhibitors (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.4.15.1

-

708856

-

3.4.15.1

IC50: 0.000085 mM

670519

-

3.4.15.1

mixed inhibition. The preferential inhibition of circulating and tissue angiotensin I-converting enzyme by nicotianamine can contribute to the suppression of hypertension

681562

-

3.4.15.1

3 entries

Enzyme Kinetic Parameters

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.6.1.80

0.4

-

-

659597

2.6.1.80

0.9

-

-

659597

2.6.1.80

2 entries

IC₅₀ Value (2 results)

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Show IC50 Value (2 entries)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

3.4.15.1

0.000085

-

IC50: 0.000085 mM

670519

3.4.15.1

0.442

-

-

708856

3.4.15.1

2 entries

References & Links

Literature References (12)

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Show Reference (12 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

639733

-

The role of nicotianamine synthase in response to Fe nutrition status in Gramineae

1996

Higuchi, K.; Kanazawa, K.; Nishizawa, N.K.; Mori, S.

Plant Soil

178

171-177

639734

-

Purification and characterization of nicotianamine synthase from Fe-deficient barley roots

1994

Higuchi, K.; Kanazawa, K.; Nishizawa, N.K.; Chino, M.; Mori, S.

Plant Soil

165

173-179

639735

-

Response of nicotianamine synthase activity to Fe-deficiency in tobacco plants as compared with barley

1995

Higuchi, K.; Nishizawa, N.K.; Yamaguchi, H.; Roemheld, V.; Marschner, H.; Mori, S.

J. Exp. Bot.

46

1061-1063

639736

9952442

Cloning of nicotianamine synthase genes, novel genes involved in the biosynthesis of phytosiderophores

1999

Higuchi, K.; Suzuki, K.; Nakanishi, H.; Yamaguchi, H.; Nishizawa, N.K.; Mori, S.

Plant Physiol.

119

471-479

659597

-

Detection of two distinct isoenzymes of nicotianamine aminotransferase in Fe-deficient barley roots

1995

Kanazawa, K.; Higuchi, K.; Nishizawa, N.K.; Fushiya, S.; Mori, S.

J. Exp. Bot.

46

1241-1244

659982

11329018

Enhanced tolerance of rice to low iron availability in alkaline soils using barley nicotianamine aminotransferase genes

2001

Takahashi, M.; Nakanishi, H.; Kawasaki, S.; Nishizawa, N.K.; Mori, S.

Nat. Biotechnol.

19

466-469

660211

10557244

Cloning two genes for nicotianamine aminotransferase, a critical enzyme in iron acquisition (Strategy II) in graminaceous plants

1999

Takahashi, M.; Yamaguchi, H.; Nakanishi, H.; Shioiri, T.; Nishizawa, N.K.; Mori, S.

Plant Physiol.

121

947-956

670519

16458941

An angiotensin-I converting enzyme inhibitor from buckwheat (Fagopyrum esculentum Moench) flour

2006

Aoyagi, Y.

Phytochemistry

67

618-621

681562

17934238

Nicotianamine preferentially inhibits angiotensin I-converting enzyme

2007

Hayashi, A.; Kimoto, K.

J. Nutr. Sci. Vitaminol.

53

331-336

708856

19994857

Antihypertensive effect of peptide-enriched soy sauce-like seasoning and identification of its angiotensin I-converting enzyme inhibitory substances

2010

Nakahara, T.; Sano, A.; Yamaguchi, H.; Sugimoto, K.; Chikata, H.; Kinoshita, E.; Uchida, R.

J. Agric. Food Chem.

58

821-827

760026

28475636

Characterisation of the nicotianamine aminotransferase and deoxymugineic acid synthase genes essential to Strategy II iron uptake in bread wheat (Triticum aestivum L.)

2017

Beasley, J.T.; Bonneau, J.P.; Johnson, A.A.T.

PLoS ONE

12

e0177061

760026

28475636

Characterisation of the nicotianamine aminotransferase and deoxymugineic acid synthase genes essential to Strategy II iron uptake in bread wheat (Triticum aestivum L.)

2017

Beasley, J.T.; Bonneau, J.P.; Johnson, A.A.T.

PLoS ONE

12

e0177061

760026

2 entries

Links to other databases for nicotianamine

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Show Links (1 entry)