Ligand thiophosphate

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Basic Ligand Information

Molecular Structure
Picture of thiophosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H3O3PS
thiophosphate
WVIMUEUQJFPNDK-PEBGCTIMSA-N
Synonyms:
phosphorothioate, phosphorothionate

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
guanosine 5'-(thio)triphosphate + H2O = GDP + thiophosphate + 3 H+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-Seryl-tRNASec + thiophosphate = Cysteyl-tRNASec + H2O + phosphate
show the reaction diagram

Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
peroxiredoxin-(S-hydroxy-S-oxocysteine) + gamma-S-ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + thiophosphate + R-S-S-R
show the reaction diagram
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methyl p-nitrophenyl phosphorothioate + H2O = methanol + p-nitrophenol + phosphorothioate
show the reaction diagram
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thiophosphonoacetaldehyde + H2O = thiophosphate + acetaldehyde
show the reaction diagram
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guanosine 5'-(thio)triphosphate + H2O = GDP + thiophosphate + 3 H+
show the reaction diagram
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ATPgammaS + H2O + H+/in = ADP + thiophosphate + H+/out
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.000867
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KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.004
-
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Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0017
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References & Links

Links to other databases for thiophosphate

ChEBI
PubChem
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PubChem