Ligand quercetin 3-sulfate
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Basic Ligand Information
Molecular Structure
C15H10O10S
quercetin 3-sulfate
DNAYVNOVGHZZLH-UHFFFAOYSA-N
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)
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3'-phosphoadenylylsulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
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3'-phosphoadenylylsulfate + quercetin 3-sulfate = quercetin 3,4'-disulfate + adenosine 3',5'-bisphosphate
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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3'-phosphoadenylylsulfate + quercetin = adenosine 3',5'-bisphosphate + quercetin 3-sulfate
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Substrate in Enzyme-catalyzed Reactions (2 results)
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3'-phosphoadenylylsulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
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3'-phosphoadenylylsulfate + quercetin 3-sulfate = quercetin 3,4'-disulfate + adenosine 3',5'-bisphosphate
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Product in Enzyme-catalyzed Reactions (2 results)
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3'-phosphoadenylylsulfate + quercetin = adenosine 3',5'-bisphosphate + quercetin 3-sulfate
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3'-phosphoadenylylsulfate + quercetin = adenosine 3',5'-bisphosphate + quercetin sulfate
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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in cultures, up to 50% decrease in enzymic activity
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noncompetitive with respect to quercetin or 3'-phosphoadenylylsulfate
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Enzyme Kinetic Parameters
KM Value (3 results)
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References & Links
Literature References (7)
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Enzymatic synthesis of sulphated flavonois in Flaveria spp.
1988
Varin, L.
Bull. Liaison-Groupe Polyphenols
14
248-257
Novel flavonol 3-sulfotransferase. Purification, kinetic properties, and partial amino acid sequence
1992
Varin, L.; Ibrahim, R.K.
J. Biol. Chem.
267
1858-1863
Cloning and regulation of flavonol 3-sulfotransferase in cell-suspension cultures of Flaveria bidentis
1994
Anavoranich, S.; Varin, L.; Gulick, P.; Ibrahim, R.
Plant Physiol.
106
485-491
Partial purification and characterization of three flavonol-specific sulfotransferases from Flaveria chloraefolia
1989
Varin, L.; Ibrahim, R.K.
Plant Physiol.
90
977-981
Molecular characterization of two plant flavonol sulfotransferases
1992
Varin, L.; DeLuca, V.; Ibrahim, R.K.; Brisson, N.
Proc. Natl. Acad. Sci. USA
89
1286-1290
Quercetin and resveratrol potently reduce estrogen sulfotransferase activity in normal human mammary epithelial cells
2000
Otake, Y.; Nolan, A.L.; Walle, U.K.; Walle, T.
J. Steroid Biochem. Mol. Biol.
73
265-270
Sulfation of Flavonoids and Other Phenolic Dietary Compounds by the Human Cytosolic Sulfotransferases
2001
Pai, T.G.; Suiko, M.; Sakakibara, Y.; Liu, M.C.
Biochem. Biophys. Res. Commun.
285
1175-1179
Links to other databases for quercetin 3-sulfate
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