Ligand bilirubin

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Basic Ligand Information

Molecular Structure
Picture of bilirubin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C33H36N4O6
bilirubin
BPYKTIZUTYGOLE-IFADSCNNSA-N
Synonyms:
(4Z,15Z)-bilirubin IX alpha, bilirubin/cytoplasm, bilirubin/vacuole, bilirubin[side 1], bilirubin[side 2]


Show all pahtways known for Show all BRENDA pathways known for bilirubin

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 bilirubin + O2 = 2 biliverdin + 2 H2O
show the reaction diagram
-
bilirubin/cytoplasm + ATP + H2O = bilirubin/vacuole + ADP + phosphate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
biliverdin + ? = bilirubin + ?
show the reaction diagram
-
bilirubin/cytoplasm + ATP + H2O = bilirubin/vacuole + ADP + phosphate
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
bilirubin + O2 = ?
show the reaction diagram
-
bilirubin/cytoplasm + ATP + H2O = bilirubin/vacuole + ADP + phosphate
show the reaction diagram
-
ATP + H2O + bilirubin[side 1] = ADP + phosphate + bilirubin[side 2]
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
biliverdin + ? = bilirubin + ?
show the reaction diagram
-
bilirubin diglucuronide + H2O = bilirubin + D-glucuronate
show the reaction diagram
-
bilirubin/cytoplasm + ATP + H2O = bilirubin/vacuole + ADP + phosphate
show the reaction diagram
-
ATP + H2O + bilirubin[side 1] = ADP + phosphate + bilirubin[side 2]
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulates the glucoronidation of 4-nitrophenol and morphine
-

Inhibitor in Enzyme-catalyzed Reactions (29 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibitor
-
0.09 mM, complete inhibition of enzyme activity in 50 : 50 chloroform-n-heptane two-phase system
-
0.0068 mM, 50% inhibition
-
0.05 mM serum unconjugated bilirubin rapidly and selectively inhibits cytochrome c oxidase activity. Pre-treatment of neurons with 0.05 mM glycoursodeoxycholic acid prior to exposure to serum unconjugated bilirubin prevents inhibition of cytrochrome c oxidase activity
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (17 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
29
-
45°C, pH 8.4, LccA protein isolated from Haloferax volcanii H26 strain US02

KM Value (34 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.236
-
45°C, pH 8.4, LccA protein isolated from Haloferax volcanii H26 strain US02

Ki Value (8 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0056
0.011
-

IC50 Value (8 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.003
-
at pH 5.5 and 37°C

References & Links

Links to other databases for bilirubin

ChEBI
PubChem
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PubChem