Ligand methionine sulfoxide

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Basic Ligand Information

Molecular Structure
Picture of methionine sulfoxide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H11NO3S
methionine sulfoxide
QEFRNWWLZKMPFJ-YGVKFDHGSA-N
Synonyms:
L-(-)-methionine S-oxide, L-methinonine S-oxide, L-methionine S-oxide, L-methionine sulfoxide, L-methionine sulphoxide, methionine-S-sulfoxide, methionine S-oxide
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-(-)-methionine S-oxide + NADPH = L-methionine + NADP+ + H2O
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-methionine + NADPH + O2 = L-methionine S-oxide + NADP+ + H2O
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-methionine sulfoxide + acetaldehyde + H2O = ?
show the reaction diagram
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methionine sulfoxide + H2O + O2 = ?
show the reaction diagram
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L-methionine sulfoxide + electron donor = L-methionine + oxidized electron donor + H2O
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L-(-)-methionine S-oxide + NADPH = L-methionine + NADP+ + H2O
show the reaction diagram
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L-methionine sulfoxide + reduced benzyl viologen = L-methionine + oxidized benzyl viologen + H2O
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acetyl-CoA + L-methionine sulfoxide = CoA + N-acetyl-L-methionine sulfoxide
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L-methionine sulfoxide + glyoxylate = 4-methylsulfinyl-2-oxobutanoate + glycine
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Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-methionine + 2-oxoglutarate + O2 = L-methionine sulfoxide + succinate + CO2
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L-methionine + 2-oxoglutarate + O2 = L-methionine sulfoxide + succinate + CO2
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitively inhibits the activity with a disulfide about 2.5fold
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10 mM, 4.0% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (22 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (9 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
25.6
-
25°C, pH not specified in the publication

KM Value (11 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
45
-
-
0.2
-
pH 7.0, 22°C
119
-
25°C, pH not specified in the publication

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
5.9
-
-
5
-
above

References & Links

Links to other databases for methionine sulfoxide

ChEBI
PubChem
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PubChem