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Ligand D-Cystine
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Basic Ligand Information
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open all tablesRoles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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EC NUMBER 
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
In Vivo Product in Enzyme-catalyzed Reactions (1 result)
EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + H2O + D-cystine-[cystine-binding protein](side 1) = ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
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Substrate in Enzyme-catalyzed Reactions (8 results)
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Product in Enzyme-catalyzed Reactions (4 results)
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + H2O + D-cystine-[cystine-binding protein](side 1) = ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
70% inhibition at 0.01 mM, binds via the cysteine moiety covalently to the catalytic Cys135 of the enzyme, pH-dependent proces, optimal at pH 7.0-7.5, inhibition is reversible by DTT, dithioerythritol, 2-mercaptoethanol, dimercaptopropanol, and reduced glutathione, no protection by aspartate-beta-semialdehyde, NADP+ or NADPH, inhibition mechanism and kinetics
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Enzyme Kinetic Parameters
KM Value (4 results)
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.34
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mutant enzyme E295S/L322T, pH and temperature not specified in the publication
References & Links
Literature References (10)
Links to other databases for D-Cystine
ChEBI
PubChem
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