Ligand D-Cystine

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Basic Ligand Information

Molecular Structure
Picture of D-Cystine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H12N2O4S2
D-Cystine
LEVWYRKDKASIDU-QWWZWVQMSA-N
Synonyms:
D-cystine(side 2), D-cystine[side 2]

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + D-cystine = CoA + N-acetyl-D-cystine
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + H2O + D-cystine-[cystine-binding protein](side 1) = ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
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Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-cystine + H2O + methylene blue = ? + NH3 + reduced methylene blue
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D-cystine + 2 GSH = 2 D-cysteine + GSSG
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acetyl-CoA + D-cystine = CoA + N-acetyl-D-cystine
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D-cystine + 2-oxoadipate = ? + 2-aminoadipate
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D-cystine + H2O = ?
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D-cystine = ?
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D-cystine + H2O = ?
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D-cystine + H2O = ?
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Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 D-Cys + O2 = D-cystine + H2O2
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ATP + H2O + D-cystine-[cystine-binding protein](side 1) = ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
70% inhibition at 0.01 mM, binds via the cysteine moiety covalently to the catalytic Cys135 of the enzyme, pH-dependent proces, optimal at pH 7.0-7.5, inhibition is reversible by DTT, dithioerythritol, 2-mercaptoethanol, dimercaptopropanol, and reduced glutathione, no protection by aspartate-beta-semialdehyde, NADP+ or NADPH, inhibition mechanism and kinetics
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Enzyme Kinetic Parameters

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.17
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enzyme B
0.27
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30°C, pH 8.0

References & Links

Links to other databases for D-Cystine

ChEBI
PubChem
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PubChem