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BRENDA support

Ligand aminomalonic acid

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Basic Ligand Information

Molecular Structure
Picture of aminomalonic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H5NO4
aminomalonic acid
JINBYESILADKFW-UHFFFAOYSA-N
Synonyms:
2-aminomalonate, 2-aminomalonic acid, alpha-aminomalonate, aminomalonate

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DL-alanine + oxomalonate = pyruvate + aminomalonic acid
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + aminomalonate = CoA + CO2 + 2-amino-3-oxobutanoate
show the reaction diagram
-
Aminomalonate = Gly + CO2
show the reaction diagram
-
ATP + 2-aminomalonic acid + tRNAAsp = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DL-alanine + oxomalonate = pyruvate + aminomalonic acid
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
decarboxylation is accompanied by a slower reaction in which the enzyne becomes irreversibly inactivated, and in which aminomalonate becomes tightly bound to the enzyme
-
10 mM, 44% inhibition
-
inhibits transfer of Asp to tRNA
-

3D Structure of Enzyme-Ligand-Complex (PDB) (26 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.025
-
with pyruvate as cosubstrate, oxidative decarboxylation

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3
-
-
8
-
ATP-diphosphate exchange

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.14
-
-
0.023
-
-

References & Links

Links to other databases for aminomalonic acid

ChEBI
PubChem
ChEBI
PubChem