Ligand 1D-myo-inositol 3-phosphate

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Basic Ligand Information

Molecular Structure
Picture of 1D-myo-inositol 3-phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H13O9P
1D-myo-inositol 3-phosphate
INAPMGSXUVUWAF-PTQMNWPWSA-N
Synonyms:
1-D-myo-inositol 1-phosphate, 1-D-myo-inositol 3-phosphate, 1D-myo-inositol (1)-monophosphate, 1D-myo-inositol (3)-monophosphate, 1D-myo-inositol-1-phosphate, 1D-myo-inositol 1-monophosphate, 1D-myo-Inositol 1-phosphate, 1L-myo-inositol-1-phosphate, 1L-myo-inositol 1-phosphate, D-inositol-1-phosphate, D-inositol 1-phosphate, D-myo-inositol-1-phosphate, D-myo-Inositol 1-monophosphate, D-myo-Inositol 1-phosphate, D-myo-inositol 3-monophosphate, D-myo-inositol 3-phosphate, Inositol-1-phosphate, Inositol 1-phosphate, inositol 3-phosphate, inositol phosphate, L-inositol 1-phosphate, L-myo-inositol-1-phosphate, L-myo-Inositol 1-phosphate, myo-inositol-1-phosphate, myo-inositol 1-phosphate, myo-inositol 3-phosphate, myo-inositol phosphate, phosphoinositol


Show all pahtways known for Show all BRENDA pathways known for 1D-myo-inositol 3-phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
show the reaction diagram
CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate = CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate
show the reaction diagram
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CDP-2,3-bis-O-(phytanyl)-sn-glycerol + 1L-myo-inositol 1-phosphate = CMP + 1-archaetidyl-1D-myo-inositol 3-phosphate
show the reaction diagram
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CDP-diacylglycerol + 1L-myo-inositol 1-phosphate = CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1D-myo-inositol 3,5-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate
show the reaction diagram
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inositol 1,3-bisphosphate + H2O = inositol 1-phosphate + phosphate
show the reaction diagram
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1-phosphatidyl-1D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + diacylglycerol
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (29 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
myo-inositol 1-phosphate + H2O = myo-inositol + phosphate
show the reaction diagram
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inositol phosphate + H2O = inositol + phosphate
show the reaction diagram
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inositol-1-phosphate + H2O = inositol + phosphate
show the reaction diagram
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myo-inositol 1-phosphate + H2O = myo-inositol + phosphate
show the reaction diagram
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CDP-2,3-di-O-phytanyl-sn-glycerol + 1D-myo-inositol 1-phosphate = archaetidylinositol phosphate + CMP
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (36 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1D-myo-inositol 3,5-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate
show the reaction diagram
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inositol 1,3-bisphosphate + H2O = inositol 1-phosphate + phosphate
show the reaction diagram
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phosphatidylinositol + H2O = 1,2-sn-diacylglycerol + phosphoinositol
show the reaction diagram
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phosphatidylinositol + H2O = diacylglycerol + inositol phosphate
show the reaction diagram
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phosphoinositide + H2O = inositol phosphate + diacylglycerol
show the reaction diagram
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phosphatidylinositol + H2O = diacylglycerol + myo-inositol 1,2-cyclic phosphate + D-myo-inositol 1-phosphate
show the reaction diagram
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phosphatidylinositol = inositol 1,2-cyclic phosphate + inositol phosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
about 20% activation, between 0.0003 mM and 0.1 mM, slightly inhibitory at higher concentrations
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibitory effects of all possible 38 regioisomers of synthetic inositol phosphates, only inositol trisphosphates and tetrakisphosphates inhibit, not or very weak: inositol monophosphates, bisphosphates and pentakisphosphates, the recognition of myo-inositol phosphate regioisomers is highly structure-selective
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weak, above 0.1 mM, stimulates below
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4% and 45% inhibition at 1 mM and 5 mM, respectively
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3D Structure of Enzyme-Ligand-Complex (PDB) (11 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (33 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (42 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for 1D-myo-inositol 3-phosphate

ChEBI
PubChem
ChEBI
PubChem