Ligand 11beta-hydroxyprogesterone

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Basic Ligand Information

Molecular Structure
Picture of 11beta-hydroxyprogesterone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H30O3
11beta-hydroxyprogesterone
BFZHCUBIASXHPK-ATWVFEABSA-N
Synonyms:
(11beta)-11-hydroxyprogesterone, 11beta-hydroxy-pregn-4-ene-3,20-dione, 11beta-hydroxy-progesterone
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
11beta-hydroxy-pregn-4-ene-3,20-dione + ? = pregn-4-ene-3,11,20-trione + ?
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pregn-4-ene-3,11,20-trione + NADPH = 11beta-hydroxy-pregn-4-ene-3,20-dione + NADP+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
11beta-hydroxy-pregn-4-ene-3,20-dione + ? = pregn-4-ene-3,11,20-trione + ?
show the reaction diagram
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11beta-Hydroxyprogesterone + NADPH + O2 = ?
show the reaction diagram
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11beta-hydroxyprogesterone + NADH + O2 = corticosterone + NAD+ + H2O
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
progesterone + reduced adrenodoxin + O2 = 11beta-hydroxyprogesterone + oxidized adrenodoxin + H2O
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
50% inhibition at 0.0004 mM
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Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0169
-
-

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.07
-
22°C

IC50 Value (3 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.00005
-
pH 8.4, 37°C

References & Links

Links to other databases for 11beta-hydroxyprogesterone

ChEBI
PubChem
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PubChem