Ligand 1-palmitoyl-sn-glycerol 3-phosphate

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Basic Ligand Information

Molecular Structure
Picture of 1-palmitoyl-sn-glycerol 3-phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C19H39O7P
1-palmitoyl-sn-glycerol 3-phosphate
YNDYKPRNFWPPFU-GOSISDBHSA-N
Synonyms:
1-hexadecanoyl-glycero-3-phosphoglycerol, 1-hexadecanoyl-sn-glycerol 3-phosphate, 1-monopalmitoyllysophosphatidylglycerol, 1-O-hexadecyl-sn-glycerol-3-phosphate (alkyl-lysophosphatidic acid), 1-palmitoyl-2-lyso-sn-glycerol 3-phosphate, 1-palmitoyl-2-lysophosphatidate, 1-palmitoyl-glycerol 3-phosphate, 1-palmitoyl-lysophosphatidic acid, 1-palmitoyl-lysophosphatidylglycerol, 1-palmitoyl-sn-glycero-3-phosphate, 1-palmitoyl-sn-glycerol-3-phosphate, 1-palmitoyl-sn-gycerol-3-phosphate, 1-palmitoylglycerol 3-phosphate, 1palmitoyl-sn-glycerol 3-phosphate, palmitoyl-lysophosphatidic acid, palmitoyl-lysophosphatidylglycerol, palmitoyl-sn-glycerol 3-phosphate, palmitoylglycerophosphate, palmitoyl lysophosphatidic acid, palmitoyllysophosphatidylglycerol
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-monopalmitoyllysophosphatidylglycerol + H2O = glycerophosphoglycerol + palmitic acid
show the reaction diagram
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palmitoyl-sn-glycerol 3-phosphate + H2O = palmitoyl-sn-glycerol + phosphate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
palmitoyl-CoA + sn-glycerol 3-phosphate = CoA + 1-palmitoyl-sn-glycerol 3-phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
palmitoylglycerone phosphate + NADPH = 1-palmitoylglycerol 3-phosphate + NADP+
show the reaction diagram
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N-palmitoyl-1-palmitoyl-2-lysophosphatidylethanolamine + H2O = N-palmitoylethanolamine + 1-palmitoyl-2-lyso-sn-glycerol 3-phosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.01 mM, 47% stimulation of arylesterase activity
-
activates the hydrolysis at a physiological pH
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0.01 mM, 14% stimulation of paraoxonase, 40% stimulation of diazoxonase
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Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
product inhibitor
-
above 0.05 mM
-
40 microM, about 50% inhibition
-
selective, noncompetitive inhibition of paraoxonase activity, charge interactions, inhibition is almost completely suppressed by 1 M NaCl
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.003
-
with oleoyl-CoA
0.22
-
-

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.041
-
pH 7.4, 25°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.02
-
pH 7.4, 37°C

References & Links

Links to other databases for 1-palmitoyl-sn-glycerol 3-phosphate

ChEBI
PubChem
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PubChem