Ligand 5-androstene-3,17-dione

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Basic Ligand Information

Molecular Structure
Picture of 5-androstene-3,17-dione (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C19H26O2
5-androstene-3,17-dione
SQGZFRITSMYKRH-QAGGRKNESA-N
Synonyms:
5-androsten-3,17-dione, 5-androstenedione, androst-5-en-3,17-dione, androst-5-ene-3,17-dione, DELTA5-androstene-3,17-dione

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-androstenedione + NADPH = 5alpha-dihydrotestosterone + NADP+
show the reaction diagram
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5-Androstene-3,17-dione = 4-Androstene-3,17-dione
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dehydroepiandrosterone + NAD+ = androst-5-en-3,17-dione + NADH
show the reaction diagram
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dehydroepiandrosterone + O2 = androst-5-en-3,17-dione + H2O2
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
androst-5-en-3,17-dione + NADH = dehydroepiandrosterone + NAD+
show the reaction diagram
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5-androstene-3,17-dione + NAD+ = dehydroepiandrosterone + NADH + H+
show the reaction diagram
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5-androstenedione + NADPH = 5alpha-dihydrotestosterone + NADP+
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dehydroepiandrosterone + NADH + H+ = 5-androstene-3,17-dione + NAD+
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive towards 5-pregnene-3,20-dione
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (66 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
4.8
-
pH 7.8, 30°C

KM Value (70 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.548
-
-
0.237
-
pH 7.8, 30°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0068
-
-

References & Links

Links to other databases for 5-androstene-3,17-dione

ChEBI
PubChem
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PubChem