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Ligand DNA containing 8-oxo-guanine residues

Basic Ligand Information

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.2.23

DNA containing 8-oxo-guanine residues + H2O = DNA + 8-oxoguanine

669289

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (6 results)

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Show Turnover Number (6 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.2.2.23

0.0003

-

mutant R108A

669289

3.2.2.23

0.0035

-

mutant H89A/R109A

669289

3.2.2.23

0.004

-

mutant K217T

669289

3.2.2.23

0.005

-

wild-type

669289

3.2.2.23

0.0059

-

mutant R109A

669289

3.2.2.23

0.0067

-

mutant H89A

669289

3.2.2.23

6 entries

K_M Value (6 results)

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Show KM Value (6 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.2.2.23

0.001

-

wild-type

669289

3.2.2.23

0.0015

-

mutant R108A

669289

3.2.2.23

0.0041

-

mutant H89A

669289

3.2.2.23

0.0041

-

mutant K217T

669289

3.2.2.23

0.227

-

mutant R109A

669289

3.2.2.23

0.44

-

mutant H89A/R109A

669289

3.2.2.23

6 entries

References & Links

Literature References (1)

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Show Reference (1 entry)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

669289

14607836

Substrate discrimination by formamidopyrimidine-DNA glycosylase: a mutational analysis

2004

Zaika, E.I.; Perlow, R.A.; Matz, E.; Broyde, S.; Gilboa, R.; Grollman, A.P.; Zharkov, D.O.

J. Biol. Chem.

279

4849-4861

Links to other databases for DNA containing 8-oxo-guanine residues

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Show Links (1 entry)