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Determination and comparison of specific activity of the HIF-prolyl hydroxylases
2004
Tuckerman, J.R.; Zhao, Y.; Hewitson, K.S.; Tian, Y.M.; Pugh, C.W.; Ratcliffe, P.J.; Mole, D.R.
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Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
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Role for casein kinase 2 in the regulation of HIF-1 activity
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Mottet, D.; Ruys, S.P.; Demazy, C.; Raes, M.; Michiels, C.
Int. J. Cancer
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Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys
2007
Li, N.; Yi, F.; Sundy, C.M.; Chen, L.; Hilliker, M.L.; Donley, D.K.; Muldoon, D.B.; Li, P.L.
Am. J. Physiol. Renal Physiol.
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An alternatively spliced transcript of the PHD3 gene retains prolyl hydroxylase activity
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Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1alpha accumulation--implications for prolyl hydroxylase activity and iron
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Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger
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Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)
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Proc. Natl. Acad. Sci. USA
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Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains
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Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migration
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Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury
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FASEB J.
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HIF alpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
2001
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Science
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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
2001
Jaakkola, P.; Mole, D.R.; Tian, Y.M.; Wilson, M.I.; Gielbert, J.; Gaskell, S.J.; von Kriegsheim, A.; Hebestreit, H.F.; Mukherji, M.; Schofield, C.J.; Maxwell, P.H.; Pugh, C.W.; Ratcliffe, P.J.
Science
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A conserved family of prolyl-4-hydroxylases that modify HIF
2001
Bruick, R.K.; McKnight, S.L.
Science
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Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites
2011
Pappalardi, M.B.; McNulty, D.E.; Martin, J.D.; Fisher, K.E.; Jiang, Y.; Burns, M.C.; Zhao, H.; Ho, T.; Sweitzer, S.; Schwartz, B.; Annan, R.S.; Copeland, R.A.; Tummino, P.J.; Luo, L.
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Inhibition of a prolyl hydroxylase domain (PHD) by substrate analog peptides
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Hypoxia-inducible factor (HIF) network: insights from mathematical models
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The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
2012
Masson, N.; Singleton, R.S.; Sekirnik, R.; Trudgian, D.C.; Ambrose, L.J.; Miranda, M.X.; Tian, Y.M.; Kessler, B.M.; Schofield, C.J.; Ratcliffe, P.J.
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A dynamic model of the hypoxia-inducible factor 1alpha (HIF-1alpha) network
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Nguyen, L.K.; Cavadas, M.A.; Scholz, C.C.; Fitzpatrick, S.F.; Bruning, U.; Cummins, E.P.; Tambuwala, M.M.; Manresa, M.C.; Kholodenko, B.N.; Taylor, C.T.; Cheong, A.
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Effects of polynitrogen compounds on the activity of recombinant human HIF-1alpha prolyl hydroxylase 3 in E. coli
2011
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J. Inorg. Biochem.
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Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH)
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Substrate preference of the HIF-prolyl hydroxylase-2 (PHD2) and substrate-induced conformational change
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Evidence for inhibition of HIF-1alpha prolyl hydroxylase 3 activity by four biologically active tetraazamacrocycles
2012
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Hyperoxia attenuates the inhibitory effect of nitric oxide donors on HIF prolyl-4-hydroxylase-2: Implication on discriminative effect of nitric oxide on HIF prolyl-4-hydroxylase-2 and collagen prolyl-4-hydroxylase
2011
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Biochem. Pharmacol.
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Alternative splicing transcription of Megalobrama amblycephala HIF prolyl hydroxylase PHD3 and up-regulation of PHD3 by HIF-1alpha
2016
Chen, N.; Huang, C.H.; Chen, B.X.; Liu, H.; Wang, W.M.; Gul, Y.; Wang, H.L.
Biochem. Biophys. Res. Commun.
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Alternative splicing transcription of Megalobrama amblycephala HIF prolyl hydroxylase PHD3 and up-regulation of PHD3 by HIF-1alpha
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Chen, N.; Huang, C.H.; Chen, B.X.; Liu, H.; Wang, W.M.; Gul, Y.; Wang, H.L.
Biochem. Biophys. Res. Commun.
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Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen
2014
Tarhonskaya, H.; Chowdhury, R.; Leung, I.K.; Loik, N.D.; McCullagh, J.S.; Claridge, T.D.; Schofield, C.J.; Flashman, E.
Biochem. J.
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Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen
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Tarhonskaya, H.; Chowdhury, R.; Leung, I.K.; Loik, N.D.; McCullagh, J.S.; Claridge, T.D.; Schofield, C.J.; Flashman, E.
Biochem. J.
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Increased turnover at limiting O2 concentrations by the Thr387 -> Ala variant of HIF-prolyl hydroxylase PHD2
2015
Pektas, S.; Taabazuing, C.Y.; Knapp, M.J.
Biochemistry
54
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Increased turnover at limiting O2 concentrations by the Thr387 -> Ala variant of HIF-prolyl hydroxylase PHD2
2015
Pektas, S.; Taabazuing, C.Y.; Knapp, M.J.
Biochemistry
54
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Enzymesubstrate reporters for evaluation of substrate specificity of HIF prolyl hydroxylase isoforms
2017
Osipyants, A.; Smirnova, N.; Khristichenko, A.; Hushpulian, D.; Nikulin, S.; Chubar, T.; Zakhariants, A.; Tishkov, V.; Gazaryan, I.; Poloznikov, A.
Biochemistry
82
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The hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regeneration
2014
Fan, L.; Li, J.; Yu, Z.; Dang, X.; Wang, K.
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Discovery of novel 2-[2-(3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetamide derivatives as HIF prolyl 4-hydroxylase inhibitors; SAR, synthesis and modeling evaluation
2014
Hong, Y.R.; Kim, H.T.; Ro, S.; Cho, J.M.; Lee, S.H.; Kim, I.S.; Jung, Y.H.
Bioorg. Med. Chem. Lett.
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HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma
2017
Miikkulainen, P.; Hoegel, H.; Rantanen, K.; Suomi, T.; Kouvonen, P.; Elo, L.L.; Jaakkola, P.M.
Cancer Metab.
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HIF hydroxylase pathways in cardiovascular physiology and medicine
2015
Bishop, T.; Ratcliffe, P.J.
Circ. Res.
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Current advances in the novel functions of hypoxia-inducible factor and prolyl hydroxylase in invertebrates
2015
Wang, L.; Cui, S.; Ma, L.; Kong, L.; Geng, X.
Insect Mol. Biol.
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Current advances in the novel functions of hypoxia-inducible factor and prolyl hydroxylase in invertebrates
2015
Wang, L.; Cui, S.; Ma, L.; Kong, L.; Geng, X.
Insect Mol. Biol.
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Hypoxia-inducible factor alpha and Hif-prolyl hydroxylase characterization and gene expression in short-time air-exposed Mytilus galloprovincialis
2015
Giannetto, A.; Maisano, M.; Cappello, T.; Oliva, S.; Parrino, V.; Natalotto, A.; De Marco, G.; Barberi, C.; Romeo, O.; Mauceri, A.; Fasulo, S.
Mar. Biotechnol.
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Hypoxia-inducible factor alpha and Hif-prolyl hydroxylase characterization and gene expression in short-time air-exposed Mytilus galloprovincialis
2015
Giannetto, A.; Maisano, M.; Cappello, T.; Oliva, S.; Parrino, V.; Natalotto, A.; De Marco, G.; Barberi, C.; Romeo, O.; Mauceri, A.; Fasulo, S.
Mar. Biotechnol.
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The endothelial prolyl-4-hydroxylase domain 2/hypoxia-inducible factor 2 axis regulates pulmonary artery pressure in mice
2016
Kapitsinou, P.P.; Rajendran, G.; Astleford, L.; Michael, M.; Schonfeld, M.P.; Fields, T.; Shay, S.; French, J.L.; West, J.; Haase, V.H.
Mol. Cell. Biol.
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The endothelial prolyl-4-hydroxylase domain 2/hypoxia-inducible factor 2 axis regulates pulmonary artery pressure in mice
2016
Kapitsinou, P.P.; Rajendran, G.; Astleford, L.; Michael, M.; Schonfeld, M.P.; Fields, T.; Shay, S.; French, J.L.; West, J.; Haase, V.H.
Mol. Cell. Biol.
36
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Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer
2017
Kozlova, N.; Wottawa, M.; Katschinski, D.M.; Kristiansen, G.; Kietzmann, T.
Oncotarget
8
9885-9898
Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer
2017
Kozlova, N.; Wottawa, M.; Katschinski, D.M.; Kristiansen, G.; Kietzmann, T.
Oncotarget
8
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Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-alpha
2014
Sun, W.; Jelkmann, W.; Depping, R.
Cell Death Dis.
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Prolyl-4-hydroxylase 2 potentially contributes to hepatocellular carcinoma-associated erythrocytosis by maintaining hepatocyte nuclear factor-4alpha expression
2015
Sun, W.; Kosyna, F.K.; Jelkmann, W.; Depping, R.
Cell. Physiol. Biochem.
37
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Prolyl-4-hydroxylase 2 potentially contributes to hepatocellular carcinoma-associated erythrocytosis by maintaining hepatocyte nuclear factor-4alpha expression
2015
Sun, W.; Kosyna, F.K.; Jelkmann, W.; Depping, R.
Cell. Physiol. Biochem.
37
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Prolyl-4-hydroxylase domain protein 2 controls NF-kappaB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus
2015
Li, J.; Yuan, W.; Jiang, S.; Ye, W.; Yang, H.; Shapiro, I.M.; Risbud, M.V.
J. Biol. Chem.
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A PHD in macrophage survival
2014
Taylor, C.T.; Scholz, C.C.
J. Leukoc. Biol.
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A PHD in macrophage survival
2014
Taylor, C.T.; Scholz, C.C.
J. Leukoc. Biol.
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Prolyl 4-hydroxylase domain protein 3-inhibited smooth-muscle-cell dedifferentiation improves cardiac perivascular fibrosis induced by obstructive sleep apnea
2019
Tong, J.; Yu, F.C.; Li, Y.; Wei, Q.; Li, C.; Zhen, P.; Zhang, G.
BioMed Res. Int.
2019
9174218
Prolyl 4-hydroxylase domain protein 3-inhibited smooth-muscle-cell dedifferentiation improves cardiac perivascular fibrosis induced by obstructive sleep apnea
2019
Tong, J.; Yu, F.C.; Li, Y.; Wei, Q.; Li, C.; Zhen, P.; Zhang, G.
BioMed Res. Int.
2019
9174218
Expression and roles of individual HIF prolyl 4-hydroxylase isoenzymes in the regulation of the hypoxia response pathway along the murine gastrointestinal epithelium
2021
Dengler, F.; Sova, S.; Salo, A.M.; Maeki, J.M.; Koivunen, P.; Myllyharju, J.
Int. J. Mol. Sci.
22
4038
Expression and roles of individual HIF prolyl 4-hydroxylase isoenzymes in the regulation of the hypoxia response pathway along the murine gastrointestinal epithelium
2021
Dengler, F.; Sova, S.; Salo, A.M.; Maeki, J.M.; Koivunen, P.; Myllyharju, J.
Int. J. Mol. Sci.
22
4038
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