Ligand 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid

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Basic Ligand Information

Molecular Structure
Picture of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C27H46O5
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid
CNWPIIOQKZNXBB-WBYPBBSPSA-N
Synonyms:
(25R)-3,7,12-trihydroxycoprostanoic acid, (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate, trihydroxycoprostanate


Show all pahtways known for Show all BRENDA pathways known for 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate + CoA = AMP + diphosphate + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trihydroxycoprostanoyl-CoA + H2O = trihydroxycoprostanate + CoA
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid + H2O + acceptor = 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoic acid + reduced acceptor
show the reaction diagram
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ATP + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate + CoA = AMP + diphosphate + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trihydroxycoprostanoyl-CoA + H2O = trihydroxycoprostanate + CoA
show the reaction diagram
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(25S)-3,7,12-trihydroxycoprostanoic acid = (25R)-3,7,12-trihydroxycoprostanoic acid
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.005 mM, 63% inhibition of the activity with chenodeoxycholate
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Enzyme Kinetic Parameters

References & Links

Links to other databases for 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid

ChEBI
PubChem
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PubChem