Ligand L-erythro-3-hydroxyaspartate

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Basic Ligand Information

Molecular Structure
Picture of L-erythro-3-hydroxyaspartate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H7NO5
L-erythro-3-hydroxyaspartate
YYLQUHNPNCGKJQ-NHYDCYSISA-N
Synonyms:
3-hydroxy-erythro-L-aspartate, erythro-3-hydroxy-L-Asp, erythro-3-hydroxy-L-aspartate, erythro-3-hydroxy-Ls-aspartate, erythro-3-hydroxyaspartic acid, erythro-beta-hydroxy-L-Asp, erythro-beta-hydroxyaspartate, erythro-L-beta-hydroxyaspartate, erythro-L-hydroxyaspartate, L-erythro-3-hydroxy-aspartate
Pathway Source
Pathways

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-hydroxy-erythro-L-aspartate + O2 = 2-amino-3-hydroxy-2-butenedioic acid + H2O2
show the reaction diagram
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L-erythro-3-hydroxyaspartate + 2-oxoglutarate = erythro-3-hydroxy-2-oxoaspartate + L-glutamate
show the reaction diagram
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erythro-beta-Hydroxyaspartate = L-Ser + CO2
show the reaction diagram
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erythro-3-Hydroxy-L-Asp = Gly + glyoxylate
show the reaction diagram
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erythro-L-beta-hydroxyaspartate = oxaloacetate + NH3
show the reaction diagram
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L-erythro-3-hydroxyaspartate = ?
show the reaction diagram

Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive versus L-aspartate and L-serine
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5 mM, decrease the enzyme activity to 15%
-
inhibits transfer of Asp to tRNA
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.173
-
pH 8.0, 25°C, recombinant wild-type enzyme
8.68
-
at pH 8.5 and 50°C

KM Value (5 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
4.7
-
pH 8.0, 25°C, recombinant wild-type enzyme
0.024
-
-
2.8
-
-
0.43
-
-
0.16
-
at pH 8.5 and 50°C

Ki Value (5 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.2
-
strong competitive inhibition

References & Links

Links to other databases for L-erythro-3-hydroxyaspartate

ChEBI
PubChem
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PubChem