Ligand glyceraldehyde 3-phosphate

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Basic Ligand Information

Molecular Structure
Picture of glyceraldehyde 3-phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H7O6P
glyceraldehyde 3-phosphate
LXJXRIRHZLFYRP-UHFFFAOYSA-N
Synonyms:
3-phosphoglyceraldehyde, D,L-glyceraldehyde 3-phosphate, DL-glyceraldehyde-3-phosphate, DL-glyceraldehyde-phosphate, DL-glyceraldehyde 3-phosphate, glyceralaldehyde-3-phosphate, glyceraldehyde-3-phosphate, glyceraldehyde phosphate, glyceraldhyde-3-phosphate
Pathway Source
Pathways
MetaCyc
1,3-propanediol biosynthesis (engineered), 2-deoxy-alpha-D-ribose 1-phosphate degradation, 2-deoxy-D-ribose degradation I, 3,6-anhydro-alpha-L-galactopyranose degradation, 3-dehydroquinate biosynthesis II (archaea) more

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DL-glyceraldehyde 3-phosphate + NADP+ + H2O = 3-phospho-DL-glycerate + NADPH + H+
show the reaction diagram
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glyceraldehyde 3-phosphate + D-glyceraldehyde 3-phosphate = D-xylulose 5-phosphate + D-xylulose 5-phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (25 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-phospho-D-glyceroyl phosphate + NADPH + H+ = DL-glyceraldehyde 3-phosphate + phosphate + NADP+
show the reaction diagram
-
-
D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + dihydroxyacetone
show the reaction diagram
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indole-3-glycerol phosphate = indole + glyceraldehyde 3-phosphate
show the reaction diagram
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L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (39 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DL-glyceraldehyde 3-phosphate + NADPH + H+ = glycerol 3-phosphate + NADP+
show the reaction diagram
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glyceraldehyde-3-phosphate + NAD(P)+ = ?
show the reaction diagram
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DL-glyceraldehyde 3-phosphate + NAD+ = ?
show the reaction diagram
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glyceraldehyde-3-phosphate + H2O + O2 = ?
show the reaction diagram
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glyceralaldehyde-3-phosphate + NAD+ + H2O = glycerate-3-phosphate + NADH
show the reaction diagram
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glyceraldehyde-3-phosphate + 2,6-dichlorophenolindophenol + H2O = 3-phospho-D-glycerate + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
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arsenate + reduced glutathione + NAD+ + glyceraldehyde-3-phosphate = arsenite + glutathione + ?
show the reaction diagram
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DL-glyceraldehyde-3-phosphate + NADPH = ?
show the reaction diagram
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dihydroxypropanone + glyceraldehyde 3-phosphate = D-fructose 6-phosphate
show the reaction diagram
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phosphoenolpyruvate + DL-glyceraldehyde 3-phosphate = pyruvate + phosphate
show the reaction diagram
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glyceraldehyde-3-phosphate + H2O = glyceraldehyde + phosphate
show the reaction diagram
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glyceraldehyde 3-phosphate + H2O = glyceraldehyde + phosphate
show the reaction diagram
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pyruvate + DL-glyceraldehyde 3-phosphate = 2-dehydro-3-deoxy-D-gluconate
show the reaction diagram
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Glyceraldehyde phosphate + acetaldehyde = Hydroxyacetaldehyde + glyceraldehyde 3-phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (54 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-phospho-D-glyceroyl phosphate + NADPH + H+ = DL-glyceraldehyde 3-phosphate + phosphate + NADP+
show the reaction diagram
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-
2-dehydro-3-deoxy-6-phospho-D-gluconate = pyruvate + glyceraldehyde-3-phosphate
show the reaction diagram
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Glyceraldehyde phosphate + acetaldehyde = Hydroxyacetaldehyde + glyceraldehyde 3-phosphate
show the reaction diagram
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indole-3-glycerol phosphate = indole + glyceraldehyde 3-phosphate
show the reaction diagram
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-
L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation
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Inhibitor in Enzyme-catalyzed Reactions (39 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibitor
-
strong inhibitor
-
substrate inhibition above 0.5 mM
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50% inhibition at 0.2 mM
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inhibits the activities of isozyme AckA1, but very poorly of isozyme AckA2; inhibits the activities of isozyme AckA1, but very poorly of isozyme AckA2
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competitive
-
competitive
-
weak
-
reacts with L-cysteinee
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at 1 mM 27% inhibition of activity (concentrations of substrates 1 mM)
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3D Structure of Enzyme-Ligand-Complex (PDB) (50 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (31 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
50
-
-
0.42
-
-
3
-
cytosolic isozyme DS-Co, pH 8.6, 37°C
0.21
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-

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
12
-
-
4
-
pH 7.5, 30°C, recombinant His-tagged isozyme AckA1

References & Links

Links to other databases for glyceraldehyde 3-phosphate

ChEBI
PubChem
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PubChem