Ligand thioredoxin-1 disulfide
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Basic Ligand Information
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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a [protein] carrying a disulfide bond + thioredoxin-1 = a [protein] with reduced L-cysteine residues + thioredoxin-1 disulfide
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Substrate in Enzyme-catalyzed Reactions (2 results)
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thioredoxin-1 disulfide + NADPH + H+ = thioredoxin-1 + NADP+
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thioredoxin-1 disulfide + NADPH = NADP+ + thioredoxin-1
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Product in Enzyme-catalyzed Reactions (1 result)
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a [protein] carrying a disulfide bond + thioredoxin-1 = a [protein] with reduced L-cysteine residues + thioredoxin-1 disulfide
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Enzyme Kinetic Parameters
KM Value (2 results)
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References & Links
Literature References (1)
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Mitochondrial and cytoplasmic thioredoxin reductase variants encoded by a single Drosophila gene are both essential for viability
2002
Missirlis, F.; Ulschmid, J.K.; Hirosawa-Takamori, M.; Gronke, S.; Schafer, U.; Becker, K.; Phillips, J.P.; Jackle, H.
J. Biol. Chem.
277
11521-11526
Links to other databases for thioredoxin-1 disulfide