Ligand CoM-S-S-CoB

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Basic Ligand Information

Molecular Structure
Picture of CoM-S-S-CoB (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C13H26NO10PS3
CoM-S-S-CoB
OBGQLHXSMIBYLN-PWSUYJOCSA-N
Synonyms:
CoB-S-S-CoM, coenzyme M-HTP heterodisulfide, coenzyme M 7-mercaptoheptanoylthreonine-phosphate hetero-disulfide, coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide, CoM-S-S-CoB5, N-(7-[(2-sulfoethyl)dithio]heptanoyl)-O3-phospho-L-threonine, N-[7-[(2-sulfoethyl)dithio]heptanoyl]-O3-phospho-L-threonine, N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine, N-{7-[(2-sulfoethyl)dithio]heptanoyl}-O3-phospho-L-threonine, O-phosphono-N-{7-[(2-sulfoethyl)disulfanyl]heptanoyl}-L-threonine


Show all pahtways known for Show all BRENDA pathways known for CoM-S-S-CoB

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + H+ = oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM
show the reaction diagram
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H2 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB = reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
fumarate + CoM + CoB = succinate + CoM-S-S-CoB
show the reaction diagram
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oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM = reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + H+
show the reaction diagram
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oxidized coenzyme F420 + reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = reduced coenzyme F420 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
show the reaction diagram
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reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = H2 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
show the reaction diagram
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CO2 + reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = formate + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + H+ = oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM
show the reaction diagram
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CoM-S-S-CoB + ? = CoM-SH + CoB-SH + ?
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CoM-S-S-CoB + methane = methyl-CoM + CoB
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Product in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
fumarate + CoM + CoB = succinate + CoM-S-S-CoB
show the reaction diagram
-
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oxidized coenzyme F420 + reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = reduced coenzyme F420 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
show the reaction diagram
-
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CO2 + reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = formate + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
50% inhibition at 0.6 mM
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Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.05
-
subunit HdrB2C2, at 21C, pH not specified in the publication

References & Links

Links to other databases for CoM-S-S-CoB

ChEBI
PubChem
ChEBI
PubChem