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Ligand CoM-S-S-CoB
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Basic Ligand Information
CoB-S-S-CoM, coenzyme M-HTP heterodisulfide, coenzyme M 7-mercaptoheptanoylthreonine-phosphate hetero-disulfide, coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide, CoM-S-S-CoB5, N-(7-[(2-sulfoethyl)dithio]heptanoyl)-O3-phospho-L-threonine, N-[7-[(2-sulfoethyl)dithio]heptanoyl]-O3-phospho-L-threonine, N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine, N-{7-[(2-sulfoethyl)dithio]heptanoyl}-O3-phospho-L-threonine, O-phosphono-N-{7-[(2-sulfoethyl)disulfanyl]heptanoyl}-L-threonine
BRENDA
MetaCyc
coenzyme B/coenzyme M regeneration I (methanophenazine-dependent), coenzyme B/coenzyme M regeneration II (ferredoxin-dependent), coenzyme B/coenzyme M regeneration III (coenzyme F420-dependent), coenzyme B/coenzyme M regeneration IV (H2-dependent), coenzyme B/coenzyme M regeneration V (formate-dependent) 
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Show all BRENDA pathways known for CoM-S-S-CoB
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open all tablesRoles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)
top
EC NUMBER 
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + 2 H+ = 2 oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM
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reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + H+ = oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM
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2 H2 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB = 2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+
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H2 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB = reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+
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In Vivo Product in Enzyme-catalyzed Reactions (18 results)
EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+ = 2 H2 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
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oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM = reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + H+
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coenzyme B + coenzyme M + methanophenazine = N-(7-[(2-sulfoethyl)dithio]heptanoyl)-O3-phospho-L-threonine + dihydromethanophenazine
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coenzyme B + coenzyme M + methanophenazine = N-[7-[(2-sulfoethyl)dithio]heptanoyl]-O3-phospho-L-threonine + dihydromethanophenazine
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2 oxidized coenzyme F420 + 2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+ = 2 reduced coenzyme F420 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
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oxidized coenzyme F420 + reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = reduced coenzyme F420 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
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2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+ = 2 H2 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
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reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = H2 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
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CO2 + reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = formate + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
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methyl-coenzyme M + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate (coenzyme B) = methane + CoB-S-S-CoM
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2-(methylthio)ethanesulfonate + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate = CoM-S-S-CoB + methane
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2-(methylthio)ethansulfonate + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate = CoM-S-S-CoB + methane
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methyl coenzyme M + coenzyme B = methane + CoM-S-S-CoB
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methyl-coenzyme M + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate (coenzyme B) = methane + CoM-S-S-CoB
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Substrate in Enzyme-catalyzed Reactions (8 results)
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + 2 H+ = 2 oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM
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reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + H+ = oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM
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2 H2 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB = 2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+
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H2 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB = reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+
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H2 + oxidized methyl viologen + CoM-S-S-CoB = reduced methyl viologen + CoB + CoM + H+
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2 formate + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB = 2 CO2 + 2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+
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Product in Enzyme-catalyzed Reactions (24 results)
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+ = 2 H2 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
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oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM = reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + H+
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coenzyme B + coenzyme M + methanophenazine = N-(7-[(2-sulfoethyl)dithio]heptanoyl)-O3-phospho-L-threonine + dihydromethanophenazine
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coenzyme B + coenzyme M + methanophenazine = N-[7-[(2-sulfoethyl)dithio]heptanoyl]-O3-phospho-L-threonine + dihydromethanophenazine
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2 oxidized coenzyme F420 + 2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+ = 2 reduced coenzyme F420 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
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oxidized coenzyme F420 + reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = reduced coenzyme F420 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
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2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+ = 2 H2 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
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reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = H2 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
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CO2 + reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = formate + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
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methyl-coenzyme M + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate (coenzyme B) = methane + CoB-S-S-CoM
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2-(methylthio)ethanesulfonate + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate = CoM-S-S-CoB + methane
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2-(methylthio)ethansulfonate + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate = CoM-S-S-CoB + methane
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methyl coenzyme M + coenzyme B = methane + CoM-S-S-CoB
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methyl-coenzyme M + coenzyme B = methane + CoM-S-S-CoB
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methyl-coenzyme M + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate (coenzyme B) = methane + CoM-S-S-CoB
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
Enzyme Kinetic Parameters
KM Value (1 result)
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
References & Links
Literature References (28)
Links to other databases for CoM-S-S-CoB
ChEBI
PubChem
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Release 2023.1 (January 2023)
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