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Ligand 4-nitrophenyl-alpha-L-idopyranosiduronate

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.76

4-nitrophenyl-alpha-L-idopyranosiduronate + H2O = 4-nitrophenol + alpha-L-iduronic acid

654716

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3.2.1.76

4-nitrophenyl-alpha-L-iduronide + H2O = 4-nitrophenol + alpha-L-iduronic acid

663579

-

3.2.1.76

2 entries

Enzyme Kinetic Parameters

K_M Value (1 result)

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EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.2.1.76

0.53

-

pH 4.5, 37°C

654716

References & Links

Literature References (2)

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BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

654716

12834357

Family 39 alpha-L-iduronidases and beta-D-xylosidases react through similar glycosyl-enzyme intermediates: Identification of the human iduronidase nucleophile

2003

Nieman, C.E.; Wong, A.W.; He, S.; Clarke, L.; Hopwood, J.J.; Withers, S.G.

Biochemistry

42

8054-8065

663579

16283671

Changes in hair morphology of mucopolysaccharidosis I patients treated with recombinant human alpha-L-iduronidase (laronidase, Aldurazyme)

2005

Kloska, A.; Bohdanowicz, J.; Konopa, G.; Tylki-Szym?ska, A.; Jakobkiewicz-Banecka, J.; Czartoryska, B.; Liberek, A.; Wegrzyn, A.; Wegrzyn, G.

Am. J. Med. Genet. A

139

199-203

Links to other databases for 4-nitrophenyl-alpha-L-idopyranosiduronate

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Show Links (1 entry)

ChEBI

PubChem

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