Ligand Ubiquinone-10

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Basic Ligand Information

Molecular Structure
Picture of Ubiquinone-10 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C59H90O4
Ubiquinone-10
ACTIUHUUMQJHFO-AMJCLVIFSA-N
Synonyms:
coenzyme ubiquinone 10, oxidized ubiquinone Q10, Q10, ubiquinone 10

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ubiquinone-10 + NAD(P)H = ubiquinol-10 + NAD(P)+
show the reaction diagram
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NADPH + H+ + ubiquinone-10 = NADP+ + ubiquinol-10
show the reaction diagram
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NADH + H+ + ubiquinone-10 = NAD+ + ubiquinol-10
show the reaction diagram
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ubiquinone-10 + ferricytochrome c = ubiquinol-10 + ferrocytochrome c + 2 H+
show the reaction diagram
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NADH + ubiquinone-10 = NAD+ + ubiquinol-10
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 ubiquinol-10 + O2 = 2 ubiquinone-10 + 2 H2O
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ubiquinone-10 + NADPH = ?
show the reaction diagram
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dihydroorotate + ubiquinone-10 = orotate + reduced ubiquinone-10
show the reaction diagram
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NADH + H+ + ubiquinone-10 = NAD+ + ubiquinol-10
show the reaction diagram
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ubiquinone-10 + NAD(P)H = ubiquinol-10 + NAD(P)+
show the reaction diagram
-
ubiquinone-10 + ferricytochrome c = ubiquinol-10 + ferrocytochrome c + 2 H+
show the reaction diagram
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NADH + ubiquinone-10 = NAD+ + ubiquinol-10
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 ubiquinol-10 + O2 = 2 ubiquinone-10 + 2 H2O
show the reaction diagram
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ubiquinol-10 + O2 = ubiquinone-10 + H2O
show the reaction diagram
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ubiquinol 10 + cytochrome c = ubiquinone 10 + reduced cytochrome c
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
CoQD, efficient, N-terminally truncated protein
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this quinone derivative is used in the study because the natural C45-plastoquinone is not available commercially
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the enzyme contains 4.2-4.5 mol of ubiquinone-10 per 650000 Da enzyme
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
below 0.015 mM
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
above 0.03 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (9 results)

Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
-999
-
KM value for complex I is 3.9 nmol/mg phospholipid

References & Links

Links to other databases for Ubiquinone-10

ChEBI
PubChem
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PubChem