Ligand 3-phospho-D-glyceroyl phosphate

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Basic Ligand Information

Molecular Structure
Picture of 3-phospho-D-glyceroyl phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H8O10P2
3-phospho-D-glyceroyl phosphate
LJQLQCAXBUHEAZ-UWTATZPHSA-N
Synonyms:
1,3-biphosphate-d-glycerate, 1,3-bisphospho-D-glycerate, 1,3-bisphosphoglycerate, 1,3-diphospho-D-glyceric acid, 1,3-diphosphoglycerate, 1,3-diphosphoglyceric acid, 3-phospho-D-glyceroyl 1-phosphate, 3-phospho-D-glyceroyl phosphate., glycerate 1,3-bisphosphate


Show all pahtways known for Show all BRENDA pathways known for 3-phospho-D-glyceroyl phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-phospho-D-glyceroyl phosphate + NADPH + H+ = D-glyceraldehyde 3-phosphate + phosphate + NADP+
show the reaction diagram
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3-phospho-D-glyceroyl phosphate + NADPH + H+ = D-glyceraldehyde 3-phosphate + phosphate + NADP+
show the reaction diagram
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3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate = 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
show the reaction diagram
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GDP + 3-phospho-D-glyceroyl 1-phosphate = GTP + 3-phospho-D-glycerate
show the reaction diagram
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ADP + 3-phospho-D-glyceroyl phosphate = ATP + 3-phospho-D-glycerate
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1,3-diphosphoglyceric acid + (polyphosphate)n = 3-phosphoglycerate + (polyphosphate)n+1
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1,3-diphosphoglycerate + H2O = 3-phosphoglycerate + phosphate
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3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate
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In Vivo Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-glyceraldehyde 3-phosphate + phosphate + NADP+ = 3-phospho-D-glyceroyl phosphate + NADPH + H+
show the reaction diagram
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ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (30 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-phospho-D-glyceroyl phosphate + NADPH + H+ = D-glyceraldehyde 3-phosphate + phosphate + NADP+
show the reaction diagram
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3-phospho-D-glyceroyl phosphate + NADPH + H+ = D-glyceraldehyde 3-phosphate + phosphate + NADP+
show the reaction diagram
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GDP + 3-phospho-D-glyceroyl 1-phosphate = GTP + 3-phospho-D-glycerate
show the reaction diagram
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1,3-diphosphoglyceric acid + (polyphosphate)n = 3-phosphoglycerate + (polyphosphate)n+1
show the reaction diagram
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Glucose 1-phosphate + 1,3-bisphosphoglycerate = Glucose 1,6-diphosphate + glycerate 3-phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (58 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-glyceraldehyde 3-phosphate + phosphate + NADP+ = 3-phospho-D-glyceroyl phosphate + NADPH + H+
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate activation

Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.385 mM and 0.005 mM, 50% inhibition of PFK I and PFK II respectively, phosphate relieves from inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (22 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (84 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
5.8
-
pH 8.0, 60°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
49.1
-
wild type enzyme, in 50 mM EPPS/NaOH (pH 8.0), 20 mM potassium phosphate, at 50°C
49.1
-
pH 8.0, 60°C

References & Links

Links to other databases for 3-phospho-D-glyceroyl phosphate

ChEBI
PubChem
ChEBI
PubChem