Ligand view of Phe-Ala (5599 - MIDZLCFIAINOQN-WPRPVWTQSA-N)

C₁₂H₁₆N₂O₃

Phe-Ala

MIDZLCFIAINOQN-WPRPVWTQSA-N

3.4.22.51

Phe-Ala-primaquine + H2O = Phe-Ala + primaquine

-

3.4.11.22

L-Phe-L-Ala + H2O = L-Phe + L-Ala

665275

-

3.4.13.19

Phe-Ala + H2O = Phe + Ala

677698

-

3.4.13.20

Phe-Ala + H2O = Phe + Ala

647116

-

3.4.17.6

Phe-Ala + H2O = Phe + Ala

81311

-

3.4.11.13

Gly-Phe-Ala + H2O = Gly + Phe-Ala

81195, 81196, 81197

-

3.4.14.4

Met-Arg-Phe-Ala + H2O = Met-Arg + Phe-Ala

36178

-

3.4.14.5

Phe-Ala-4-nitroanilide + H2O = Phe-Ala + 4-nitroaniline

-

Phe-Ala-primaquine + H2O = Phe-Ala + primaquine

-

3.4.23.18

Benzyloxycarbonyl-Lys-Phe-Ala + H2O = Benzyloxycarbonyl-Lys + Phe-Ala

30566

-

3.4.23.29

Phe-Ala-Ala-Ala + H2O = Phe-Ala + Ala-Ala

30730

-

3.4.24.27

GFA + H2O = Phe-Ala + Gly

-

N-acetyl-Thr-Glu-Phe-Ala + H2O = N-acetyl-Thr-Glu + Phe-Ala

-

41% inhibition at 1 mM

-

-

-

at least 30% inhibition at 0.3 mM

-

-

-

in the absence of dipeptides, transporter shows proton-dependent leak currents that are inhibited by Phe-Ala; in the absence of dipeptides, transporter shows proton-dependent leak currents that are inhibited by Phe-Ala, Trp-Ala, and Phe-Phe

719903

-

28733

13271

Dipeptidyl carboxypeptidase from Escherichia coli

1976

Yaron, A.

Methods Enzymol.

45

599-610

30566

4581238

Comparative specificity of microbial acid proteinases for synthetic peptides. 3. Relationship with their trypsinogen activating ability

1973

Morihara, K.; Oka, T.

Arch. Biochem. Biophys.

157

561-572

30730

-

Purification and characterization of a pepstatin-insensitive carboxyl proteinase from Polyporus tulipiferae (Irpex lacteus)

1985

Kobayashi, H.; Kusakabe, I.; Murakami, K.

Agric. Biol. Chem.

49

2393-2397

31110

3123480

Critical ionizing groups in Aeromonas neutral protease

1988

Wilkes, S.H.; Bayliss, M.E.; Prescott, J.M.

J. Biol. Chem.

263

1821-1825

36178

3348886

Dipeptidyl peptidase III from human erythrocytes

1988

Abramic, M.; Zubanovic, M.; Vitale, L.

Biol. Chem. Hoppe-Seyler

369

29-38

36229

6756314

Rat intestinal brush border membrane dipeptidyl-aminopeptidase IV: kinetic properties and substrate specificities of the purified enzyme

1982

Bella, A.M.; Erickson, R.H.; Kim, Y.S.

Arch. Biochem. Biophys.

218

156-162

81195

4318

An extracellular aminopeptidase from Clostridium histolyticum

1976

Kessler, E.; Yaron, A.

Eur. J. Biochem.

63

271-287

81196

13266

Extracellular aminopeptidase from Clostridium histolyticum

1976

Kessler, E.; Yaron, A.

Methods Enzymol.

45

544-552

81197

4631895

A novel aminopeptidase from Clostridium histolyticum

1973

Kessler, E.; Yaron, A.

Biochem. Biophys. Res. Commun.

50

405-412

81311

5806587

Bacterial peptidases. 3. An enzyme specific for N-acyl linkages to alanine

1969

Levy, C.C.; Goldman, P.

J. Biol. Chem.

244

4467-4472

638927

6773940

Bacillus megaterium spore protease. Action of the enzyme on peptides containing the amino acid sequence cleaved by the enzyme in vivo

1980

Dignam, S.S.; Setlow, P.

J. Biol. Chem.

255

8408-8412

647116

1903095

Purification and properties of human serum carnosinase

1991

Jackson, M.C.; Kucera, C.M.; Lenney, J.F.

Clin. Chim. Acta

196

193-206

649283

12675220

Exploration of the active site of dipeptidyl peptidase IV from Porphyromonas gingivalis: comparison with the human enzyme

2003

Lambeir, A.M.; Rea, D.; Fulop, V.; Kumagai, Y.; Augustyns, K.; De Meester, I.; Haemers, A.; Scharpe, S.

Adv. Exp. Med. Biol.

524

29-35

650280

9003446

Additional data about thermolysin specificity in buffer- and glycerol-containing media

1997

Ligne, T.; Pauthe, E.; Monti, J.P.; Gacel, G.; Larreta-Garde, V.

Biochim. Biophys. Acta

1337

143-148

665275

15969531

Characteristics of an aminopeptidase from Japanese cedar (Cryptomeria japonica) pollen

2005

Nagata, H.; Takei, T.; Kojima, R.; Kodera, Y.; Nishimura, H.; Inada, Y.; Matsushima, A.

J. Agric. Food Chem.

53

5445-5448

677698

17601807

Characterization of a Bifidobacterium longum BORI dipeptidase belonging to the U34 family

2007

Seo, J.M.; Ji, G.E.; Cho, S.H.; Park, M.S.; Lee, H.J.

Appl. Environ. Microbiol.

73

5598-5606

699225

18343901

Functional characterization and specific effects of various peptides on enzymatic activity of a DPP-III homologue from goat brain

2008

Dhanda, S.; Singh, H.; Singh, J.; Singh, T.P.

J. Enzyme Inhib. Med. Chem.

23

174-181

719903

20937801

Functional properties of the Arabidopsis peptide transporters AtPTR1 and AtPTR5

2010

Hammes, U.; Meier, S.; Dietrich, D.; Ward, J.; Rentsch, D.

J. Biol. Chem.

285

39710-39717

-

Ligand Phe-Ala

Basic Ligand Information

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

Substrate in Enzyme-catalyzed Reactions (4 results)

Product in Enzyme-catalyzed Reactions (16 results)

Inhibitor in Enzyme-catalyzed Reactions (5 results)

Enzyme Kinetic Parameters

References & Links

Literature References (18)

Links to other databases for Phe-Ala