Ligand P1,P3-bis(5'-adenosyl)triphosphate

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Basic Ligand Information

Molecular Structure
Picture of P1,P3-bis(5'-adenosyl)triphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H27N10O16P3
P1,P3-bis(5'-adenosyl)triphosphate
QCICUPZZLIQAPA-XPWFQUROSA-N
Synonyms:
A(5')p3(5')A, adenosine(5')triphospho(5')adenosine, diadenosine 5',5'''-P1,P3-triphosphate, diadenosine 5',5''-P1, P3-triphosphate, diadenosine 5',5''-P1,P3-triphosphate, diadenosine 5',5'-triphosphate, P1,P3-bis(5'-adenosyl) triphosphate, P1,P3-di(adenosine-5') triphosphate, P1,P3-di(adenosine-5')triphosphate, P1,P4-bis(5'-adenosyl) triphosphate, P1-(5'-adenosyl),P3-(5'-adenosyl)triphosphate, P1-P3-bis(5'-adenosyl) triphosphate
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
diadenosine 5',5''-P1,P3-triphosphate + H2O = AMP + ADP
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dimethylallyl diphosphate + P1,P3-bis(5'-adenosyl)triphosphate = ?
show the reaction diagram
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ATP + adenosine(5')triphospho(5')adenosine = diphosphate + ?
show the reaction diagram
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diadenosine 5',5'''-P1,P3-triphosphate + H2O = AMP + ADP
show the reaction diagram
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P1,P3-bis(5'-adenosyl)triphosphate + H2O = AMP + ADP
show the reaction diagram
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P1,P3-bis(5'-adenosyl)triphosphate + H2O = AMP + ADP
show the reaction diagram
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P1,P3-bis(5'-adenosyl)triphosphate + L-tryptophan + tRNATrp = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
adenosine 5'-phosphoimidazolide + ADP = imidazole + A(5')p3(5')A
show the reaction diagram
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AMP + ADP = P1,P3-bis(5'-adenosyl) triphosphate
show the reaction diagram
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L-tryptophan + ATP + ADP = P1,P3-bis(5'-adenosyl)triphosphate + ?
show the reaction diagram
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ATP + ATP = diadenosine 5',5''-P1,P3-triphosphate + ?
show the reaction diagram
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ATP + ADP = P1-(5'-adenosyl),P3-(5'-adenosyl)triphosphate + diphosphate
show the reaction diagram
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ATP + ATP = P1,P3-bis(5'-adenosyl) triphosphate + ?
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition
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crystal structure of the complex with pancreatic ribonuclease A
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3D Structure of Enzyme-Ligand-Complex (PDB) (27 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (5 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.00008
-
pH 7.2, 22°C

KM Value (22 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.021
-
pH 7.2, 22°C

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.061
-
at 27°C in 50 mM Tris buffer (pH 7.4) containing 5 mM MgCl2, 50 mM KCl, and 0.2 mM dithiothreitol

References & Links

Links to other databases for P1,P3-bis(5'-adenosyl)triphosphate

ChEBI
PubChem
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PubChem