Ligand 2',4,4',6'-tetrahydroxychalcone

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Basic Ligand Information

Molecular Structure
Picture of 2',4,4',6'-tetrahydroxychalcone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C15H12O5
2',4,4',6'-tetrahydroxychalcone
YQHMWTPYORBCMF-ZZXKWVIFSA-N
Synonyms:
(2E)-3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one, 2',4',6',4-tetrahydroxy chalcone, 2',4',6',4-tetrahydroxychalcone, chalconaringenin, naringenin chalcone, trans-2',4,4',6'-tetrahydroxychalcone

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2',4',6',4-tetrahydroxychalcone + O2 = aureusidin + H2O
show the reaction diagram
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dimethylallyl diphosphate + naringenin chalcone = diphosphate + desmethylxanthohumol
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(2S)-naringenin = naringenin chalcone
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
naringenin chalcone + 2-oxoglutarate + O2 = eriodictyol chalcone
show the reaction diagram
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2',4',6',4-tetrahydroxychalcone + O2 = aureusidin + H2O
show the reaction diagram
-
S-adenosyl-L-methionine + chalconaringenin = S-adenosyl-L-homocysteine + ?
show the reaction diagram
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UDP-glucuronate + 2',4,4',6'-tetrahydroxychalcone = ?
show the reaction diagram
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UDPglucose + 2',4',6',4-tetrahydroxychalcone = UDP + 2',4',6',4-tetrahydroxychalcone 4'-O-glucoside
show the reaction diagram
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UDP-alpha-D-glucose + 2',4,4',6'-tetrahydroxychalcone = UDP + 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside
show the reaction diagram
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dimethylallyl diphosphate + naringenin chalcone = diphosphate + desmethylxanthohumol
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (17 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (19 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0043
-
pH 6.6
0.237
-
pH 7.5, 30°C
0.13
-
-

References & Links

Links to other databases for 2',4,4',6'-tetrahydroxychalcone

ChEBI
PubChem
ChEBI
PubChem