Ligand 5'-S-methyl-5'-thioinosine

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Basic Ligand Information

Molecular Structure
Picture of 5'-S-methyl-5'-thioinosine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C11H14N4O4S
5'-S-methyl-5'-thioinosine
GXYLOXCSJFJFKA-IOSLPCCCSA-N
Synonyms:
5'-methylthioinosine, Methylthioinosine, S-methyl-5'-thioinosine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5'-methylthioinosine + phosphate = hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate
show the reaction diagram
-
S-methyl-5'-thioinosine + phosphate = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-methyl-5'-thioadenosine + H2O = S-methyl-5'-thioinosine + NH3
show the reaction diagram
-
-
5'-methylthioadenosine + H2O = 5'-methylthioinosine + NH3
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5'-methylthioinosine + phosphate = hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate
show the reaction diagram
-
5'-methylthioinosine + H2O = 5-methylthio-D-ribose + hypoxanthine
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-methyl-5'-thioadenosine + H2O = S-methyl-5'-thioinosine + NH3
show the reaction diagram
-
-
5'-methylthioadenosine + H2O = 5'-methylthioinosine + NH3
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates at 0.05-0.2 mM
-

Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
weak competitive inhibitor, above 0.5 mM
-
weak inhibition
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (14 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (16 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.03
-
in 50 mM potassium phosphate (pH 7.0), at 37°C

References & Links

Links to other databases for 5'-S-methyl-5'-thioinosine

ChEBI
PubChem
ChEBI
PubChem