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BRENDA support

Ligand Leu-Trp

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Basic Ligand Information

Molecular Structure
Picture of Leu-Trp (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C17H23N3O3
Leu-Trp
BQVUABVGYYSDCJ-ZFWWWQNUSA-N
Synonyms:
L-Leu-L-Trp

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Leu-Trp + O2 = Leu-alpha,beta-dehydrotryptamine + CO2 + H2O
show the reaction diagram
-
Leu-Trp + H2O = Leu + Trp
show the reaction diagram
-
Leu-Trp + H2O = Leu + Trp
show the reaction diagram
-
Leu-Trp + H2O = Leu + Trp
show the reaction diagram
-
Leu-Trp + H2O = Leu + Trp
show the reaction diagram
-
Leu-Trp + H2O = Leu + Trp
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Leu-Trp-Met-Arg-Phe-Ala + H2O = Leu-Trp-Met + Arg-Phe-Ala + Leu-Trp + Met-Arg-Phe-Ala
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibitor, 90% inhibition at 1 mM
-
IC50: 0.0174 mM, non-competitive
-
37% inhibition at 3.2 mM
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
92.6
-
-

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.96
-
-
0.488
-
-

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.039
-
in 50 mM Tris-HCl, pH 8.5, with 100 mM NaCl and 1 mM beta-mercaptoethanol, at 37°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0174
-
IC50: 0.0174 mM, non-competitive

References & Links

Links to other databases for Leu-Trp

ChEBI
PubChem
ChEBI
PubChem