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BRENDA support

Ligand inositol 1,3,4-trisphosphate

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Basic Ligand Information

Molecular Structure
Picture of inositol 1,3,4-trisphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H15O15P3
inositol 1,3,4-trisphosphate
MMWCIQZXVOZEGG-NCGNNJKGSA-N
Synonyms:
1D-myo-inositol-1,3,4-trisphosphate, 1D-myo-inositol 1,2,4-trisphosphate, 1D-myo-inositol 1,3,4-trisphosphate, D-myo-inositol (1,3,4)-trisphosphate, D-myo-inositol 1,3,4-triphosphate, D-myo-Inositol 1,3,4-trisphosphate, inositol(1,3,4)-trisphosphate, inositol (1,3,4)-trisphosphate, inositol-1,3,4-trisphosphate, myo-inositol-1,3,4-trisphosphate, myo-inositol 1,3,4-trisphosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-myo-inositol 1,3,4-trisphosphate + H2O = D-myo-inositol 3,4-bisphosphate + phosphate
show the reaction diagram
-
D-myo-inositol 1,3,4-trisphosphate + H2O = D-myo-inositol 3,4-bisphosphate + phosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation of inositol-1,3,4,5,6-phosphate 1-phosphatase activity
-

Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
potently inhibits hITPK1 activity towards insositol (3,4,5,6)-tetrakisphosphate, IC50: 0.0076 mM
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (7 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00008
-
-
0.02
-
37°C
0.1
-
-

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0002
-
pH 7.2, 37°C
0.00015
-
-
0.00175
-
pH 7.4, 37°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0076
-
potently inhibits hITPK1 activity towards insositol (3,4,5,6)-tetrakisphosphate, IC50: 0.0076 mM

References & Links

Links to other databases for inositol 1,3,4-trisphosphate

ChEBI
PubChem
-
PubChem