print visible entries

print all entries

Ligand Ethionine

Basic Ligand Information

Molecular Structure

close all tables

open all tables

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

top print hide

Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.4.1.11

DL-ethionine + H2O = ?

701880

-

4.4.1.11

ethionine = ?

34518, 34519, 34520, 34523, 34535, 34534, 34521

-

4.4.1.11

2 entries

Product in Enzyme-catalyzed Reactions (3 results)

top print hide

Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.6.1.7

L-vinylglycine + ethanethiol = ethionine

636615

-

3.4.13.12

ethionyl-Ala + H2O = ethionine + Ala

36096

-

3.5.1.14

acetyl-DL-ethionine + H2O = acetate + DL-ethionine

-

-

Activator in Enzyme-catalyzed Reactions (2 results)

top print hide

Show Activating Compound (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.4.13.9

enhances the activity of isozyme prolidase I, D,L-ethionine strongly enhances the activity of isozyme prolidase II compared with L-ethionine

695528

-

4.2.1.22

i.e. 2-amino-4-(ethylthio)butyric acid, an methionine analogue, which is converted to S-adenosyl-ethionine in vivo and activates CBS, treatment increased liver CBS activity 4.0fold in wild-type mice

714912

-

Inhibitor in Enzyme-catalyzed Reactions (8 results)

top print hide

Show Inhibitors (8 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.31

-

486782

-

2.5.1.49

-

637834

-

2.5.1.6

-

639046

-

2.5.1.6

32-38% inhibition with 5 mM; 32-38% inhibition with 5 mM; 32-38% inhibition with 5 mM

639063

-

2.5.1.6

2 entries

3.4.13.9

activates at concentrations of 1-50 mM, overview

679283

-

4.1.99.1

-

37341

-

4.1.99.1

competitive with S-o-nitrophenyl-L-Cys

37339

-

4.1.99.1

2 entries

6.1.1.10

methionyl-tRNA formation

64

-

Enzyme Kinetic Parameters

K_i Value (1 result)

top print hide

Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.5.1.6

0.71

-

-

639046

References & Links

Literature References (20)

top print hide

Show Reference (20 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

64

16661668

Methionyl-tRNA synthetase from Phaseolus aureus. Purification and properties

1981

Burnell, J.N.

Plant Physiol.

67

325-329

34518

955094

Purification and properties of methioninase from Pseudomonas ovalis

1976

Tanaka, H.; Esaki, N.; Yamamoto, T.; Soda, K.

FEBS Lett.

66

307-311

34519

8440

Purification and characterization of methioninase from Pseudomonas putida

1976

Ito, S.; Nakamura, T.; Eguchi, Y.

J. Biochem.

79

1263-1272

34520

831771

Properties of L-methionine gamma-lyase from Pseudomonas ovalis

1977

Tanaka, H.; Esaki, N.; Soda, K.

Biochemistry

16

100-106

34521

-

Purification and properties of L-methionine gamma-lyase from Aeromonas sp.

1984

Nakayama, T.; Esaki, N.; Lee, W.J.; Tanaka, I.; Tanaka, H.; Soda, K.

Agric. Biol. Chem.

48

2367-2369

34523

-

A versatile bacterial enzyme: L-methionine gamma-lyase

1985

Tanaka, H.; Esaki, N.; Soda, K.

Enzyme Microb. Technol.

7

530-537

34534

9726878

Purification and characterization of L-methionine gamma-lyase from Brevibacterium linens BL2

1998

Dias, B.; Weimer, B.

Appl. Environ. Microbiol.

64

3327-3331

34535

8616859

Gene cloning and characterization of Pseudomonas putida L-methionine-alpha-deamino-gamma-mercaptomethane-lyase

1996

Hori, H.; Takabayashi, K.; Orvis, L.; Carson, D.A.; Nobori, T.

Cancer Res.

56

2116-2122

36096

4280316

Partial purification and characterization of two peptidases from Neurospora crassa

1974

Johnson, G.L.; Brown, J.L.

Biochim. Biophys. Acta

370

530-540

37339

321445

Monovalent cation activation of tryptophanase

1977

Suelter, C.H.; Snell, E.E.

J. Biol. Chem.

252

1852-1857

37341

236639

Tryptophanase: structure, catalytic activities, and mechanism of action

1975

Snell, E.E.

Adv. Enzymol. Relat. Areas Mol. Biol.

42

287-333

486782

1126938

Purification and properties of homoserine transacetylase from Bacillus polymyxa

1975

Wyman, A.; Paulus, H.

J. Biol. Chem.

250

3897-3903

636615

-

Deamination and gamma-addition reactions of vinylglycine catalyzed by yeast kynurenine aminotransferase, and suicidal inactivation of the enzyme during its processing

1988

Asada, Y.; Tanizawa, K.; Yonaha, K.; Soda, K.

Agric. Biol. Chem.

52

2873-2878

637834

6526818

O-Acetylhomoserine sulfhydrylase of the fission yeast Schizosaccharomyces pombe: Partial purification, characterization, and its probable role in homocysteine biosynthesis

1984

Yamagata, S.

J. Biochem.

96

1511-1523

639046

8457607

S-adenosylmethionine synthetase in bloodstream Trypanosoma brucei

1993

Yarlett, N.; Garofalo, J.; Goldberg, B.; Ciminelli, M.A.; Ruggiero, V.; Sufrin, J.R.; Bacchi, C.J.

Biochim. Biophys. Acta

1181

68-76

639063

9037140

Three differentially expressed S-adenosylmethionine synthetases from Catharanthus roseus: molecular and functional characterization

1997

Schroeder, G.; Eichel, J.; Breinig, S.; Schroeder, J.

Plant Mol. Biol.

33

211-222

679283

16899234

Different effects of sulfur amino acids on prolidase and prolinase activity in normal and prolidase-deficient human erythrocytes

2007

Uramatsu, M.; Liu, G.; Uramatsu, S.; Zhang, M.; Wang, W.; Nakayama, K.; Manabe, M.; Kodama, H.

Clin. Chim. Acta

375

129-135

695528

19263194

Characterization of prolidase I and II purified from normal human erythrocytes: comparison with prolidase in erythrocytes from a patient with prolidase deficiency

2009

Uramatsu, S.; Liu, G.; Yang, Q.; Uramatsu, M.; Chi, H.; Lu, J.; Yamashita, K.; Kodama, H.

Amino Acids

37

543-551

701880

20146062

Microbial L-methioninase: production, molecular characterization, and therapeutic applications

2010

El-Sayed, A.S.

Appl. Microbiol. Biotechnol.

86

445-467

714912

20955694

Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice

2011

Jensen, K.K.; Geoghagen, N.S.; Jin, L.; Holt, T.G.; Luo, Q.; Malkowitz, L.; Ni, W.; Quan, S.; Waters, M.G.; Zhang, A.; Zhou, H.H.; Cheng, K.; Luo, M.J.

Eur. J. Pharmacol.

650

86-93

Links to other databases for Ethionine

top print hide

Show Links (1 entry)

ChEBI

PubChem

-