Ligand Barbiturate

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Basic Ligand Information

Molecular Structure
Picture of Barbiturate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H4N2O3
Barbiturate
DTOSIQBPPRVQHS-PDBXOOCHSA-N
Synonyms:
Barbituric acid
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ureidomalonic acid = barbiturate + H2O
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
50 mM, complete loss of activity
-
5.95% inhibition at 0.2 mM
-
2 mM, 60% inhibition
-
dead-end inhibitor, competitive with respect to (S)-dihydroorotate
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binding structure model
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mutant enzyme C155S
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3D Structure of Enzyme-Ligand-Complex (PDB) (6 results)

Enzyme Kinetic Parameters

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for Barbiturate

ChEBI
PubChem
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PubChem