Ligand Alpha-NAD+

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Basic Ligand Information

Molecular Structure
Picture of Alpha-NAD+ (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H27N7O14P2
Alpha-NAD+
BAWFJGJZGIEFAR-OPDHFMQKSA-N
Synonyms:
alphaNAD+

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5alpha-androstan-3alpha-ol-17-one + alpha-NAD+ = 5alpha-dihydrotestosterone + alpha-NADH + H+
show the reaction diagram
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alpha-NAD+ + H2O = ADP-ribose + nicotinamide
show the reaction diagram
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alpha-NAD+ + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5alpha-dihydrotestosterone + alpha-NADH + H+ = 5alpha-androstan-3alpha-ol-17-one + alpha-NAD+
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
3.6% of the activity with NAD+
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Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
noncompetitive inhibitor versus beta-NAD+
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33% inhibition, activity with NADPH and NAD+
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weak
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0.5 mM, 40% inhibition of the 116000 Da enzyme, 44% inhibition of the 90000 Da enzyme
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5 mM, 70% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

References & Links

Links to other databases for Alpha-NAD+

ChEBI
PubChem
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PubChem