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BRENDA support

Ligand 6-Thioxanthine

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Basic Ligand Information

Molecular Structure
Picture of 6-Thioxanthine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H4N4OS
6-Thioxanthine
RJOXFJDOUQJOMQ-UHFFFAOYSA-N
Synonyms:
2-Hydroxy-6-mercaptopurine

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6-thioxanthine + H2O + O2 = 6-thiouric acid + H2O2
show the reaction diagram
-
6-thioxanthine + alpha-D-ribose 1-phosphate = 6-thioxanthosine + phosphate
show the reaction diagram
-
thymidine + 2-hydroxy-6-mercaptopurine = more
show the reaction diagram
-
2-hydroxy-6-mercaptopurine + 5-phospho-alpha-D-ribose 1-diphosphate = 2-hydroxy-6-mercaptopurine ribotide + diphosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6-thioguanine + H2O = 6-thioxanthine + NH3
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
2.76
-
25°C

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00046
-
25°C

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.027
-
-
1.1
-
-
0.34
-
-

References & Links

Links to other databases for 6-Thioxanthine

ChEBI
PubChem
-
PubChem