HOME
login
history
all enzymes
BRENDA home
Ligand 4-hydroxyphenylacetic acid
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
(4-hydroxyphenyl)acetate, (4-hydroxyphenyl)acetic acid, (4-hydroxyphenyl)glyoxylate, 2-(4-hydroxyphenyl)acetate, 4-hydroxyphenylacetate, 4-hydroxyphenyl acetic acid, 4-hydroxy phenyl acetic acid, 4-hydroxyphenylactate, p-hydroxyphenylacetate, p-hydroxyphenylacetic acid, [4-hydroxyphenyl]acetic acid
Show all pathways known for 4-hydroxyphenylacetic acid
close all tables
open all tablesRoles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (22 results)
top
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EC NUMBER 
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-hydroxyphenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O
4-hydroxyphenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O
4-hydroxyphenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O
4-hydroxyphenylacetate + NAD(P)H + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
4-hydroxyphenylacetate + NAD(P)H + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
4-hydroxyphenylacetate + NAD(P)H + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O
4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O
4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O
4-hydroxyphenylacetate + NADPH + H+ + O2 = 3,4-dihydroxyphenylacetate + NADP+ + H2O
4-hydroxyphenylacetate + NADPH + H+ + O2 = 3,4-dihydroxyphenylacetate + NADP+ + H2O
4-hydroxyphenylacetate + NADPH + H+ + O2 = 3,4-dihydroxyphenylacetate + NADP+ + H2O
4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H2O
4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H2O
4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H2O
4-hydroxyphenylacetate + FMNH + O2 = 3,4-dihydroxyphenylacetate + FMN + H2O
4-hydroxyphenylacetate + FMNH + O2 = 3,4-dihydroxyphenylacetate + FMN + H2O
4-hydroxyphenylacetate + FMNH + O2 = 3,4-dihydroxyphenylacetate + FMN + H2O
4-hydroxyphenylacetate + FMNH2 + O2 = 3,4-dihydroxyphenylacetate + FMN + H2O
4-hydroxyphenylacetate + FMNH2 + O2 = 3,4-dihydroxyphenylacetate + FMN + H2O
4-hydroxyphenylacetate + FMNH2 + O2 = 3,4-dihydroxyphenylacetate + FMN + H2O
In Vivo Product in Enzyme-catalyzed Reactions (4 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Substrate in Enzyme-catalyzed Reactions (39 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-hydroxyphenylacetate + NADH + O2 + H2O = 3,4-dihydroxyphenylacetate + OH- + NAD+
-
4-hydroxyphenylacetate + NAD(P)H + O2 = homogentisate + NAD(P)+ + H2O
-
peroxynitrite + 4-hydroxyphenylacetic acid + NADPH + H+ = 4-hydroxyl-3-nitro-phenylacetic acid + NADP+ + H2O
-
4-hydroxyphenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O
4-hydroxyphenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O
4-hydroxyphenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O
4-hydroxyphenylacetate + NAD(P)H + O2 = 3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
4-hydroxyphenylacetate + NAD(P)H + O2 = 3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
4-hydroxyphenylacetate + NAD(P)H + O2 = 3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
4-hydroxyphenylacetate + NAD(P)H + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
4-hydroxyphenylacetate + NAD(P)H + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
4-hydroxyphenylacetate + NAD(P)H + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O
4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O
4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O
4-hydroxyphenylacetic acid + O2 + NADH + H+ = 3,4-dihydroxyphenylacetic acid + H2O + NAD+
4-hydroxyphenylacetic acid + O2 + NADH + H+ = 3,4-dihydroxyphenylacetic acid + H2O + NAD+
4-hydroxyphenylacetic acid + O2 + NADH + H+ = 3,4-dihydroxyphenylacetic acid + H2O + NAD+
4-hydroxyphenylacetate + NADPH + H+ + O2 = 3,4-dihydroxyphenylacetate + NADP+ + H2O
4-hydroxyphenylacetate + NADPH + H+ + O2 = 3,4-dihydroxyphenylacetate + NADP+ + H2O
4-hydroxyphenylacetate + NADPH + H+ + O2 = 3,4-dihydroxyphenylacetate + NADP+ + H2O
4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H2O
4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H2O
4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H2O
4-hydroxyphenylacetate + FMNH + O2 = 3,4-dihydroxyphenylacetate + FMN + H2O
4-hydroxyphenylacetate + FMNH + O2 = 3,4-dihydroxyphenylacetate + FMN + H2O
4-hydroxyphenylacetate + FMNH + O2 = 3,4-dihydroxyphenylacetate + FMN + H2O
4-hydroxyphenylacetate + FMNH2 + O2 = 3,4-dihydroxyphenylacetate + FMN + H2O
4-hydroxyphenylacetate + FMNH2 + O2 = 3,4-dihydroxyphenylacetate + FMN + H2O
4-hydroxyphenylacetate + FMNH2 + O2 = 3,4-dihydroxyphenylacetate + FMN + H2O
(4-hydroxyphenyl)acetate + H+ = 4-methylphenol + CO2
ATP + 4-hydroxyphenylacetate + CoA = AMP + diphosphate + 4-hydroxyphenylacetyl-CoA
-
Product in Enzyme-catalyzed Reactions (16 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
p-hydroxybenzylpenicillin + H2O = 6-aminopenicillanate + p-hydroxyphenylacetic acid
Activator in Enzyme-catalyzed Reactions (5 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
Inhibitor in Enzyme-catalyzed Reactions (19 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
effects on enzyme kinetics with substrate N,N-dimethyl-4-phenylenediamine, overview
-
inhibition of the dehydration step by 4-hydroxyphenylacetate at pH 9.0
inhibition of the dehydration step by 4-hydroxyphenylacetate at pH 9.0
inhibition of the dehydration step by 4-hydroxyphenylacetate at pH 9.0
3D Structure of Enzyme-Ligand-Complex (PDB) (6 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EC NUMBER
ENZYME 3D STRUCTURE
Enzyme Kinetic Parameters
kcat Value (Turnover Number) (10 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
343
-
native C1-C2 system or complete enzyme, respectively, pH 7.5; native C1-C2 system or complete enzyme, respectively, pH 7.5
389
-
recombinant C1-C2 system or complete enzyme, respectively, pH 7.5; recombinant C1-C2 system or complete enzyme, respectively, pH 7.5
110
-
in 100 mM Tris-HCl, pH 7.5, 40 mM NaCl, 5 mM MgCl2, 5 mM (NH4)2SO4, 5 mM cysteine, 25 mM substrate, and 5 mM dithiothreitol, at 30°C
135
-
in 100 mM Tris-HCl, pH 7.5, 40 mM NaCl, 5 mM MgCl2, 5 mM (NH4)2SO4, 5 mM cysteine, 25 mM substrate, and 5 mM dithiothreitol, at 30°C
KM Value (17 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
15
-
native C1-C2 system or complete enzyme, respectively, pH 7.5, with FAD as cosubstrate; native C1-C2 system or complete enzyme, respectively, pH 7.5, with FAD as cosubstrate
16
-
recombinant C1-C2 system or complete enzyme, respectively, pH 7.5, with FAD as cosubstrate; recombinant C1-C2 system or complete enzyme, respectively, pH 7.5, with FAD as cosubstrate
25
-
native C1-C2 system or complete enzyme, respectively, pH 7.5, with FMN as cosubstrate; native C1-C2 system or complete enzyme, respectively, pH 7.5, with FMN as cosubstrate
26
-
recombinant C1-C2 system or complete enzyme, respectively, pH 7.5, with FMN as cosubstrate; recombinant C1-C2 system or complete enzyme, respectively, pH 7.5, with FMN as cosubstrate
0.358
-
in 100 mM Tris-HCl, pH 7.5, 40 mM NaCl, 5 mM MgCl2, 5 mM (NH4)2SO4, 5 mM cysteine, 25 mM substrate, and 5 mM dithiothreitol, at 30°C
0.649
-
in 100 mM Tris-HCl, pH 7.5, 40 mM NaCl, 5 mM MgCl2, 5 mM (NH4)2SO4, 5 mM cysteine, 25 mM substrate, and 5 mM dithiothreitol, at 30°C
Ki Value (6 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
IC50 Value (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
References & Links
Literature References (74)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Links to other databases for 4-hydroxyphenylacetic acid
ChEBI
PubChem
Use of this online version of BRENDA is free but requires a license. See terms of use.
Information
