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Ligand indole-3-acetyl-L-aspartate

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

MetaCyc

indole-3-acetate inactivation II, indole-3-acetate inactivation III, indole-3-acetate inactivation IV, indole-3-acetate inactivation VI, indole-3-acetate inactivation VII, indole-3-acetate inactivation VIII, indole-3-acetate inactivation VIII more

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.1.134

(indol-3-yl)acetyl-L-aspartate + H2O = (indol-3-yl)acetate + L-aspartate

754740

-

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.1.134

(indol-3-yl)acetyl-L-aspartate + H2O = (indol-3-yl)acetate + L-aspartate

754740, 755035, 755043

-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

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Show Inhibitors (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

4.2.1.20

allosteric effector, binds to the alpha-subunit, slightly inhibitory effect on the enzyme complex, stabilization of the alpha-aminoacrylate Schiff base by perturbing the equilibrium of the catalytic intermediates formed at the beta-active site

650304

1k3u, 3D-view

4.2.1.20

inhibitor of the alpha-subunit

652224

1k3u, 3D-view

4.2.1.20

2 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

4.2.1.20

1k3u, 3D-view

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.5.1.134

13.5

-

pH 7.0, 30°C

755043

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

4.2.1.20

1.67

-

pH 7.8, 20°C

650304

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

650304

10669793

Novel allosteric effectors of the tryptophan synthase alpha(2)beta(2) complex identified by computer-assisted molecular modeling

2000

Marabotti, A.; Cozzini, P.; Mozzarelli, A.

Biochim. Biophys. Acta

1476

287-299

652224

11756456

Crystal structures of a new class of allosteric effectors complexed to tryptophan synthase

2002

Weyand, M.; Schlichting, I.; Marabotti, A.; Mozzarelli, A.

J. Biol. Chem.

277

10647-10652

754740

9747708

The gene for indole-3-acetyl-L-aspartic acid hydrolase from Enterobacter agglomerans molecular cloning, nucleotide sequence, and expression in Escherichia coli

1998

Chou, J.C.; Mulbry, W.W.; Cohen, J.D.

Mol. Gen. Genet.

259

172-178

755035

-

N-carbobenzyloxy-D-aspartic acid as a competitive inhibitor of indole-3-acetyl-L-aspartic acid hydrolase of Enterobacter agglomerans

2002

Chou, J.; Mulbry, W.; Cohen, J.

Plant Growth Regul.

37

241-248

755043

12226446

Partial purification and characterization of an inducible indole-3-acetyl-L-aspartic acid hydrolase from Enterobacter agglomerans

1996

Chou, J.; Kuleck, G.; Cohen, J.; Mulbry, W.

Plant Physiol.

112

1281-1287

Links to other databases for indole-3-acetyl-L-aspartate

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Show Links (1 entry)

ChEBI

PubChem