Ligand Glutarate

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Basic Ligand Information

Molecular Structure
Picture of Glutarate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H8O4
Glutarate
JFCQEDHGNNZCLN-UHFFFAOYSA-N
Synonyms:
Glutaric acid, L-glutarate, pentan-1,5-dioic acid, pentanedioate, pentanedioic acid


Show all pahtways known for Show all BRENDA pathways known for Glutarate

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glutaramic acid + H2O = glutaric acid + NH3
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2
show the reaction diagram
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L-glutarate + 2-oxobutanoate = 2-oxoglutarate + 2-aminobutanoate
show the reaction diagram
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glutaconyl-CoA + glutarate = glutaconate + glutaryl-CoA
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succinyl-CoA + glutarate = glutaryl-CoA + succinate
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glutarate + succinyl-CoA = ? + succinate
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glutarate + H+ = butanoate + CO2
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ATP + glutarate + CoA = AMP + diphosphate + glutaryl-CoA
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ATP + pentanedioic acid + CoA = AMP + diphosphate + pentanedioyl-CoA
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ATP + glutarate + CoA = AMP + diphosphate + glutaryl-CoA
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ATP + glutarate + CoA = ADP + phosphate + glutaryl-CoA
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ATP + pentanedioate + NH4+ = ADP + phosphate + ?
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Product in Enzyme-catalyzed Reactions (88 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
taurine + alpha-ketoadipate + O2 = sulfite + aminoacetaldehyde + pentan-1,5-dioic acid + CO2
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naringenin + 2-oxoadipate + O2 = dihydrokaempferol + pentanedioate + CO2
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2-oxoadipate + L-arginine + O2 = glutarate + CO2 + guanidine + (S)-1-pyrroline-5-carboxylate + H2O
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glutaraldehyde + NAD+ + H2O = glutarate + NADH
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glutaraldehyde + NADP+ + H2O = glutarate + NADPH + H+
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glutaraldehyde + NAD+ = glutaric acid + NADH
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glutaraldehyde + NAD+ = glutarate + NADH
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glutaraldehyde + H2O + oxidized methyl viologen = glutarate + H+ + reduced methyl viologen
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glutaraldehyde + H2O + benzylviologen = glutarate + reduced benzylviologen
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glutaryl-CoA + acetate = glutarate + acetyl-CoA
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glutaryl-CoA = glutarate + CoA
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glutaryl-CoA + H2O = CoA + glutarate
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glutaryl-CoA + H2O = CoA + glutarate
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succinamic acid + H2O = pentanedioic acid + NH3
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glutaryl-7-aminocephalosporanic acid + H2O = glutarate + 7-aminocephalosporanic acid
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glutaramate + H2O = glutarate + NH3
show the reaction diagram
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glutaronitrile + H2O = glutaric acid + NH3
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Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates at lower 2-oxoglutarate concentration
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inducer for cephalosporin acylase synthesis
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stimulates
activates
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Inhibitor in Enzyme-catalyzed Reactions (39 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits at 10 mM
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57% inhibition at 5 mM
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most potent competitive inhibitor
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at 20 mM, 25% inhibition
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at 6.67 mM 62% inhibition
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competitive inhibitor
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competitive inhibition of 15%
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63% inhibition at 0.5 mM
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6 mM, 5% inhibition
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weak
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0.1 M, weak
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competitive inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (18 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.0051
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pH and temperature not specified in the publication

KM Value (8 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.65
-
pH 7.2, 30°C
0.7
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cosubstrate glutaconyl-CoA
40.9
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37°C, pH 7.8

Ki Value (19 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.6
-
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
30
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pH 7.0, 20°C
0.35
-
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1
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at pH 7.0
26
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pH 7.2

References & Links

Links to other databases for Glutarate

ChEBI
PubChem
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PubChem