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Ligand glutaric acid

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for glutaric acid

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (8 results)

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Show Natural Product (8 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.20

5-oxopentanoate + NADP+ + H2O = glutarate + NADPH + H+

0

-

1.2.1.20

glutarate semialdehyde + NAD+ + H2O = glutarate + NADH

0

-

1.2.1.20

glutarate semialdehyde + NAD+ + H2O = glutarate + NADH + 2 H+

0

-

1.2.1.20

glutarate semialdehyde + NADP+ + H2O = glutaric acid + NADPH + H+

0

-

1.2.1.20

4 entries

1.2.1.88

glutaric semialdehyde + NAD+ + H2O = glutarate + NADH + H+

0

-

3.5.1.4

glutaramic acid + H2O = glutaric acid + NH3

209109

-

3.5.1.93

(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate

0

-

3.5.1.93

glutaryl-7-aminocephalosporanic acid + H2O = 7-aminocephalosporanic acid + glutarate

0

-

3.5.1.93

2 entries

Substrate in Enzyme-catalyzed Reactions (24 results)

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Show Substrate (24 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.11.64

glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2

754854, 754595

-

1.2.1.30

glutarate + NADPH + H+ + ATP = 5-oxopentanoate + 1,5-pentanedial + NADP+ + AMP + diphosphate

763295

-

1.2.1.30

glutarate + NADPH + H+ + ATP = ? + NADP+ + AMP + diphosphate

763295

-

1.2.1.30

2 entries

2.6.1.9

L-glutarate + 2-oxobutanoate = 2-oxoglutarate + 2-aminobutanoate

684151

-

2.7.2.11

ATP + glutaric acid = ?

761064

-

2.8.3.12

glutaconyl-CoA + glutarate = glutaconate + glutaryl-CoA

645952

-

2.8.3.13

3-hydroxy-3-methylglutaryl-CoA + glutarate = 3-hydroxy-3-methylglutarate + glutaryl-CoA

643834, 738808

-

2.8.3.13

adipyl-CoA + glutarate = adipate + glutaryl-CoA

643834

-

2.8.3.13

malonyl-CoA + glutarate = malonate + glutaryl-CoA

643834

-

2.8.3.13

methylmalonyl-CoA + glutarate = methylmalonate + glutaryl-CoA

643834

-

2.8.3.13

succinyl-CoA + glutarate = succinate + glutaryl-CoA

643834

-

2.8.3.13

5 entries

2.8.3.18

succinyl-CoA + glutarate = glutaryl-CoA + succinate

721675

-

2.8.3.26

glutarate + succinyl-CoA = ? + succinate

747846

-

3.5.1.3

glutarate + H2O = ?

288884, 288888, 288892

-

3.5.1.3

glutarate + hydroxylamine = glutaryl hydroxamate

288889, 288888

-

3.5.1.3

2 entries

4.1.1.88

glutarate + H+ = butanoate + CO2

687489

-

6.2.1.14

ATP + glutarate + CoA = AMP + diphosphate + glutaryl-CoA

745844

-

6.2.1.23

ATP + pentanedioic acid + CoA = AMP + diphosphate + pentanedioyl-CoA

701

-

6.2.1.25

ATP + glutarate + CoA = AMP + diphosphate + glutaryl-CoA

651721

-

6.2.1.5

ATP + glutarate + CoA = ADP + phosphate + glutaryl-CoA

674857

-

6.2.1.6

ATP + glutarate + CoA = ADP + phosphate + glutaryl-CoA

828

-

6.2.1.6

GTP + glutarate + CoA = GDP + phosphate + glutaryl-CoA

828

-

6.2.1.6

ITP + glutarate + CoA = IDP + phosphate + glutaryl-CoA

828

-

6.2.1.6

3 entries

6.3.1.2

ATP + pentanedioate + NH4+ = ADP + phosphate + ?

743570

-

Product in Enzyme-catalyzed Reactions (90 results)

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Show Product (90 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.11.17

taurine + alpha-ketoadipate + O2 = sulfite + aminoacetaldehyde + pentan-1,5-dioic acid + CO2

0

-

1.14.11.9

naringenin + 2-oxoadipate + O2 = dihydrokaempferol + pentanedioate + CO2

439124

-

1.14.20.7

2-oxoadipate + L-arginine + O2 = glutarate + CO2 + guanidine + (S)-1-pyrroline-5-carboxylate + H2O

0

-

1.2.1.20

5-oxopentanoate + NADP+ + H2O = glutarate + NADPH + H+

0

-

1.2.1.20

glutarate semialdehyde + NAD+ + H2O = glutarate + NADH

0

-

1.2.1.20

glutarate semialdehyde + NAD+ + H2O = glutarate + NADH + 2 H+

0

-

1.2.1.20

glutarate semialdehyde + NADP+ + H2O = glutarate + NADPH

0

-

1.2.1.20

glutarate semialdehyde + NADP+ + H2O = glutaric acid + NADPH + H+

0

-

1.2.1.24

glutaraldehyde + NAD+ + H2O = glutarate + NADH

0

-

1.2.1.24

glutaric semialdehyde + NAD+ + H2O = glutarate + NADH

0

-

1.2.1.26

glutaraldehyde + NAD(P)+ + H2O = glutarate + NAD(P)H + H+

0

-

1.2.1.26

glutaric semialdehyde + NADP+ + H2O = glutarate + NADPH

288177

-

1.2.1.20

5 entries

1.2.1.24

2 entries

1.2.1.26

2 entries

1.2.1.3

glutaraldehyde + NAD+ + H2O = glutarate + NADH

0

-

1.2.1.4

glutaraldehyde + NADP+ + H2O = glutarate + NADPH + H+

0

-

1.2.1.48

glutaraldehyde + NAD+ = glutaric acid + NADH

390324

-

1.2.1.5

glutaraldehyde + NAD+ = glutarate + NADH

0

-

1.2.1.65

glutaraldehyde + NAD+ + H2O = glutarate + NADH + 2 H+

0

-

1.2.1.65

glutaraldehyde + NAD+ + H2O = glutarate + NADH + H+

0

-

1.2.1.65

2 entries

1.2.1.79

glutaric semialdehyde + NADP+ + H2O = glutarate + NADPH + 2 H+

0

-

1.2.1.88

glutaric semialdehyde + NAD+ + H2O = glutarate + NADH + H+

0

-

1.2.3.1

glutaraldehyde + H2O + O2 = glutarate + H2O2

0

-

1.2.3.1

glutaraldehyde + O2 + H2O = glutarate + H2O2

0

-

1.2.5.2

glutaraldehyde + 2 ferricyanide + H2O = glutarate + 2 ferrocyanide + 2 H+

0

-

1.2.5.2

glutaraldehyde + 4 ferricyanide + 2 H2O = glutarate + 4 ferrocyanide + 4 H+

0

-

1.2.5.2

glutaraldehyde + oxidized phenazine methosulfate = glutaric acid + reduced phenazine methosulfate

0

-

1.2.3.1

2 entries

1.2.5.2

3 entries

1.2.7.5

glutaraldehyde + H2O + oxidized methyl viologen = glutarate + H+ + reduced methyl viologen

0

-

1.2.99.6

Glutaraldehyde + benzyl viologen = Glutarate + reduced benzyl viologen

0

-

1.2.99.6

glutaraldehyde + benzyl viologen = glutaric acid + reduced benzyl viologen

0

-

1.2.99.6

2 entries

1.2.99.7

glutaraldehyde + H2O + benzylviologen = glutarate + reduced benzylviologen

0

-

2.8.3.12

glutaryl-CoA + acetate = glutarate + acetyl-CoA

94485, 645952, 645954, 645957

-

2.8.3.13

glutaryl-CoA + 3-hydroxy-3-methylglutarate = glutarate + 3-hydroxy-3-methylglutaryl-CoA

643834

-

2.8.3.13

glutaryl-CoA + adipate = glutarate + adipyl-CoA

643834

-

2.8.3.13

glutaryl-CoA + malonate = glutarate + malonyl-CoA

643834

-

2.8.3.13

glutaryl-CoA + methylmalonate = glutarate + methylmalonyl-CoA

643834

-

2.8.3.13

glutaryl-CoA + succinate = glutarate + succinyl-CoA

643834

-

3.1.1.47

1-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O = 1-hexadecyl-glycero-3-phosphocholine + glutarate

80946, 80951, 80955, 80948

-

3.1.1.47

1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 1-palmitoyl-sn-glycero-3-phosphocholine + glutarate

653695

-

2.8.3.13

5 entries

3.1.1.47

2 entries

3.1.2.1

glutaryl-CoA = glutarate + CoA

0

-

3.1.2.20

glutaryl-CoA + H2O = CoA + glutarate

0

-

3.1.2.3

glutaryl-CoA + H2O = CoA + glutarate

0

-

3.5.1.11

glutaryl-7-aminocephalosporanic acid + H2O = glutarate + 7-aminocephalosporanic acid

0

-

3.5.1.3

glutaramate + H2O = glutarate + NH3

0

-

3.5.1.4

5-[(4-nitrophenyl)amino]-5-oxopentanoic acid + H2O = glutarate + 4-nitroaniline

0

-

3.5.1.4

glutaramic acid + H2O = glutaric acid + NH3

209109

-

3.5.1.93

(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate

0

-

3.5.1.93

4-(glutarylamino)benzoic acid + H2O = glutarate + 4-aminobenzoate

0

-

3.5.1.93

5-oxo-5-(1-phenylethoxy)pentanoic acid + H2O = glutarate + ?

0

-

3.5.1.93

glutaryl 7-aminodeacetoxycephalosporanic acid + H2O = 7-aminodeacetoxycephalosporanic acid + glutarate

0

-

3.5.1.93

glutaryl deacetoxy 7-aminocephalosporanic acid + H2O = deacetoxycephalosporanic acid + glutarate

0

-

3.5.1.93

glutaryl deacetyl-7-aminocephalosporanic acid + H2O = deacetyl-7-aminocephalosporanic acid + glutarate

0

-

3.5.1.93

glutaryl-3-chloro-7-aminodesacetoxycephalosporanic acid + H2O = glutarate + 3-chloro-7-aminodesacetoxycephalosporanate

0

-

3.5.1.93

glutaryl-7-amino cephalosporanic acid + H2O = 7-aminocephalosporanate + glutarate

0

-

3.5.1.93

glutaryl-7-aminocephalosporanic acid + H2O = 7-aminocephalosporanate + glutarate

0

-

3.5.1.93

glutaryl-7-aminocephalosporanic acid + H2O = 7-aminocephalosporanic acid + glutarate

0

-

3.5.1.93

glutaryl-7-aminocephalosporanic acid + H2O = glutarate + 7-aminocephalosporanate

0

-

3.5.1.93

glutaryl-7-aminodesacetoxycephalosporanic acid + H2O = glutarate + 7-aminodesacetoxycephalosporanate

0

-

3.5.1.93

glutaryl-alanyl-proline + H2O = glutarate + alanyl-proline

0

-

3.5.1.93

glutaryl-aminopenicillanic acid + H2O = glutarate + aminopenicillanic acid

0

-

3.5.1.93

glutaryl-D-Phe-Gly + H2O = glutarate + D-Phe-Gly

0

-

3.5.1.93

glutaryl-deacetoxy-7-aminocephalosporanic acid + H2O = deacetoxycephalosporanic acid + glutarate

0

-

3.5.1.93

glutaryl-EGDPPDLADQG + H2O = glutarate + EGDPPDLADQG

0

-

3.5.1.93

glutaryl-gamma-Glu-Cys-Gly + H2O = glutarate + gamma-Glu-Cys-Gly

0

-

3.5.1.93

glutaryl-GDAADAADKG + H2O = glutarate + GDAADAADKG

0

-

3.5.1.93

glutaryl-GDPP + H2O = glutarate + GDPP

0

-

3.5.1.93

glutaryl-GDPPDLADQG + H2O = glutarate + GDPPDLADQG

0

-

3.5.1.93

glutaryl-GGGGAA + H2O = glutarate + GGGGAA

0

-

3.5.1.93

glutaryl-GGGGGK + H2O = glutarate + GGGGGK

0

-

3.5.1.93

glutaryl-glycine + H2O = glutarate + glycine

0

-

3.5.1.93

glutaryl-glycyl-L-proline + H2O = glutarate + glycyl-L-proline

0

-

3.5.1.93

glutaryl-glycyl-proline + H2O = glutarate + glycylproline

0

-

3.5.1.93

glutaryl-L-Ala + H2O = glutarate + L-Ala

0

-

3.5.1.93

glutaryl-L-Phe + H2O = glutarate + L-Phe

0

-

3.5.1.93

glutaryl-L-Phe-Gly + H2O = glutarate + L-Phe-Gly

0

-

3.5.1.93

glutaryl-tryptophan + H2O = glutarate + tryptophan

0

-

3.5.1.93

glutarylaniline + H2O = glutarate + aniline

0

-

3.5.1.93

N-glutaryl-D-alanine methyl ester + H2O = glutarate + D-alanine methyl ester

0

-

3.5.1.93

N-glutaryl-D-phenylalanine + H2O = glutarate + D-Phe

0

-

3.5.1.93

N-glutaryl-D-phenylalanine methyl ester + H2O = glutarate + D-phenylalanine methyl ester

0

-

3.5.1.93

N-glutaryl-D-phenylglycine + H2O = glutarate + D-phenylglycine

0

-

3.5.1.93

N-glutaryl-D-phenylglycine methyl ester + H2O = glutarate + D-phenylglycine methyl ester

0

-

3.5.1.93

N-glutaryl-L-Ala + H2O = glutarate + L-Ala

0

-

3.5.1.93

N-glutaryl-L-alanine methyl ester + H2O = glutarate + L-alanine methyl ester

0

-

3.5.1.93

N-glutaryl-L-phenylalanine + H2O = glutarate + L-Phe

0

-

3.5.1.93

N-glutaryl-L-phenylalanine methyl ester + H2O = glutarate + L-phenylalanine methyl ester

0

-

3.5.1.93

N-glutaryl-L-phenylglycine + H2O = glutarate + L-phenylglycine

0

-

3.5.1.93

N-glutaryl-L-phenylglycine methyl ester + H2O = glutarate + L-phenylglycine methyl ester

0

-

3.5.1.93

N-glutarylglycine methyl ester + H2O = glutarate + glycine methyl ester

0

-

3.5.1.4

2 entries

3.5.1.93

43 entries

3.5.5.1

glutaronitrile + H2O = glutaric acid + NH3

0

-

3.5.5.7

glutaronitrile + H2O = glutarate + NH3

0

-

3.5.5.7

glutaronitrile + H2O = glutaric acid + NH3

0

-

3.5.5.7

2 entries

Activator in Enzyme-catalyzed Reactions (4 results)

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Show Activating Compound (4 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.4.1.4

activates at lower 2-oxoglutarate concentration

675825

-

3.5.1.93

inducer for cephalosporin acylase synthesis

686238

-

4.1.1.15

stimulates

3977

1xey, 3D-view

4.1.2.4

activates

5170, 5168, 5169

-

Inhibitor in Enzyme-catalyzed Reactions (41 results)

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Show Inhibitors (41 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.40

inhibits at 10 mM

739641

-

1.13.11.20

-

741585

-

1.13.12.2

57% inhibition at 5 mM

440273

-

1.14.11.2

-

439217

-

1.14.11.2

competitive inhibitor with respect to 2-oxoglutarate, noncompetitive with respect to Fe2+

439193

-

1.14.11.2

2 entries

1.14.11.7

-

349014

-

1.2.1.88

-

739954

-

1.4.1.14

most potent competitive inhibitor

391480

-

1.4.1.2

competitive inhibitor

727061

-

1.4.1.2

uncompetitive versus L-glutamate, competitive versus NAD+

727059

-

1.4.1.3

-

391541

-

1.4.1.3

shows no affinity for N6-linked NAD+ but is biospecifically adsorbed to S6-linked NAD+ derivatives in the presence of its soluble kinetic-based enzyme capture ligand glutarate

671289

-

1.4.1.2

2 entries

1.4.1.3

2 entries

1.4.1.4

at 20 mM, 25% inhibition

391668

-

1.4.3.1

at 6.67 mM 62% inhibition

391727

-

1.4.3.7

competitive inhibitor

395286

-

1.5.1.7

-

685171

-

2.3.1.92

competitive inhibition of 15%

706128

-

2.3.3.14

-

672072

-

2.6.1.1

isozyme AAT1: competitive

639882

1ams, 3D-view

2.6.1.1

isozyme AAT1: competitive

639882

1czc, 3D-view

2.6.1.1

isozyme AAT1: competitive

639882

7kzd, 3D-view

2.6.1.1

weak

639860

1ams, 3D-view

2.6.1.1

weak

639860

1czc, 3D-view

2.6.1.1

weak

639860

7kzd, 3D-view

2.6.1.1

6 entries

2.6.1.19

-

661189

-

2.6.1.2

10 mM, 94% inhibition

636726

-

2.6.1.2

2.5 mM, 69% inhibition

672286

-

2.6.1.2

about 70% inhibition, both isoforms

662840

-

2.6.1.2

3 entries

2.6.1.23

63% inhibition at 0.5 mM

639934

-

2.6.1.39

6 mM, 5% inhibition

639979

-

2.6.1.6

-

640167

-

2.7.1.106

weak

640350

-

2.8.3.5

0.1 M, weak

645967

-

3.5.1.29

competitive inhibition

172028

-

3.5.1.93

competitive

662549

-

3.5.1.93

-

661389

-

3.5.1.93

20 mM, 28% loss of activity

661368

-

4.1.1.15

-

3975

1xey, 3D-view

4.1.1.15

inhibits 42% at 1 mM

696820

1xey, 3D-view

3.5.1.93

3 entries

4.1.1.15

2 entries

4.2.1.104

-

210682

-

5.5.1.5

-

3718

-

3D Structure of Enzyme-Ligand-Complex (PDB) (24 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (24 entries)

EC NUMBER

ENZYME 3D STRUCTURE

1.3.99.1

3p4r, 3D-view

1.5.1.12

4lh3, 3D-view

2.5.1.30

4jxy, 3D-view

2.6.1.1

1ams, 3D-view

2.6.1.1

1czc, 3D-view

2.6.1.1

7kzd, 3D-view

2.6.1.1

1ams, 3D-view

2.6.1.1

1czc, 3D-view

2.6.1.1

7kzd, 3D-view

2.6.1.1

1ams, 3D-view

2.6.1.1

1czc, 3D-view

2.6.1.1

7kzd, 3D-view

2.6.1.1

1ams, 3D-view

2.6.1.1

1czc, 3D-view

2.6.1.1

7kzd, 3D-view

2.6.1.1

1ams, 3D-view

2.6.1.1

1czc, 3D-view

2.6.1.1

7kzd, 3D-view

2.6.1.1

1ams, 3D-view

2.6.1.1

1czc, 3D-view

2.6.1.1

7kzd, 3D-view

2.6.1.1

18 entries

2.6.1.42

1iyd, 3D-view

4.1.1.15

1xey, 3D-view

4.2.1.1

5nya, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

6.2.1.14

0.0051

-

pH and temperature not specified in the publication

745844

K_M Value (8 results)

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Show KM Value (8 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.14.11.64

0.65

-

pH 7.2, 30°C

754854

2.8.3.12

0.7

-

cosubstrate glutaconyl-CoA

645952

2.8.3.13

0.18

-

pH 7.8, 30°C, cosubstrate adipylCoA

643834

2.8.3.13

0.26

-

pH 7.8, 30°C, cosubstrate malonylCoA

643834

2.8.3.13

0.45

-

pH 7.8, 30°C, cosubstrate succinylCoA

643834

2.8.3.13

0.5

-

pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA

643834

2.8.3.13

0.84

-

pH 7.8, 30°C, cosubstrate methylmalonylCoA

643834

2.8.3.13

5 entries

2.8.3.26

40.9

-

37°C, pH 7.8

747846

K_i Value (19 results)

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Show KI Value (19 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.14.11.2

1.5

-

-

439217

1.14.11.2

4.2

-

-

439193

1.14.11.2

2 entries

1.14.11.7

3.6

-

competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate

349014

1.2.1.88

30

-

pH 7.0, 20°C

739954

1.4.1.14

0.35

-

-

391480

1.4.1.2

3

-

pH 8.0, 40°C, Ki(slope), at 2.5 mM NAD+

727059

1.4.1.2

53

-

pH 8.0, 40°C, Ki(intercept), at 120 mM L-glutamate

727059

1.4.1.3

0.07

-

at pH 8.5

671289

1.4.1.3

0.09

-

at pH 7.4

671289

1.4.1.2

2 entries

1.4.1.3

2 entries

1.5.1.7

1

-

at pH 7.0

685171

2.3.3.14

26

-

pH 7.2

672072

2.6.1.1

15.05

-

isozyme AAT1, 25°C, versus 2-oxoglutarate

639882

2.6.1.1

26.55

-

isozyme AAT1, 25°C, versus L-aspartate

639882

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wild-type, pH 7.8, 25°C

661189

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mutant V241A, pH 7.8, 25°C

661189

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mutant I50Q, pH 7.8, 25°C

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2 entries

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3 entries

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Amino Acids

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The glutamine synthetase of Trypanosoma cruzi is required for its resistance to ammonium accumulation and evasion of the parasitophorous vacuole during host-cell infection

2018

Crispim, M.; Damasceno, F.S.; Hernandez, A.; Barison, M.J.; Pretto Sauter, I.; Souza Pavani, R.; Santos Moura, A.; Pral, E.M.F.; Cortez, M.; Elias , M.C.; Silber, A.M.

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Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters

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Succinyl-CoA mesaconate CoA-transferase and mesaconyl-CoA hydratase, enzymes of the methylaspartate cycle in Haloarcula hispanica

2017

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Front. Microbiol.

8

1683

754595

31363033

Regulation of glutarate catabolism by GntR family regulator CsiR and LysR family regulator GcdR in Pseudomonas putida KT2440

2019

Zhang, M.; Kang, Z.; Guo, X.; Guo, S.; Xiao, D.; Liu, Y.; Ma, C.; Gao, C.; Xu, P.

mBio

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30498244

Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate

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Knorr, S.; Sinn, M.; Galetskiy, D.; Williams, R.; Wang, C.; Mueller, N.; Mayans, O.; Schleheck, D.; Hartig, J.

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Characterisation of a putative glutamate 5-kinase from Leishmania donovani

2018

Sienkiewicz, N.; Ong, H.B.; Fairlamb, A.H.

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2662-2678

763295

31430496

Engineering and characterization of hybrid carboxylic acid reductases

2019

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Links to other databases for glutaric acid

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