Ligand N-acetyl-L-glutamic acid

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Basic Ligand Information

Molecular Structure
Picture of N-acetyl-L-glutamic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C7H11NO5
N-acetyl-L-glutamic acid
RFMMMVDNIPUKGG-YFKPBYRVSA-N
Synonyms:
Ac-Glu, acetyl-Glu, acetyl-glutamate, acetyl-L-glutamate, acetylglutamate, N-acetyl-Glu, N-acetyl-glutamate, N-acetyl-L-Glu, N-acetyl-L-glutamate, N-acetylglutamate, N-acetylglutamic acid, N-alpha-acetyl-L-glutamate, Nalpha-acetyl-L-Glu, thiol-blocking agents, Thiol blocking agents


Show all pahtways known for Show all BRENDA pathways known for N-acetyl-L-glutamic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (32 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N2-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L-glutamate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (55 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-ornithine + N-acetyl-L-glutamate = N2-acetyl-L-ornithine + L-glutamate
show the reaction diagram
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N-acetyl-L-Glu + H2O = L-Glu + acetate
show the reaction diagram
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Nalpha-acetyl-L-Glu + H2O = methanol + CO2 + L-Glu
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (34 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-acetyl-Glu-tRNA + H2O = N-acetyl-Glu + tRNA
show the reaction diagram
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N-acetyl-Glu p-nitroanilide + H2O = N-acetyl-Glu + p-nitroaniline
show the reaction diagram
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N-acetyl-L-Gln + H2O = N-acetyl-L-Glu + NH3
show the reaction diagram
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N-acetyl-L-Gln + H2O = N-acetyl-L-Glu + NH3
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.015 mM, 30% inhibition
-
inhibition of methotrexate hydrolysis
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0.058 mM, 50% inhibition
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20 mM: 78% inhibition
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kinetics, competitive inhibition, Ki: 6 mM
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competitive inhibitor
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3D Structure of Enzyme-Ligand-Complex (PDB) (20 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (57 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (58 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
17.1
-
-

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.058
-
-
6
-
kinetics, competitive inhibition

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
25
-
pH and temperature not specified in the publication

References & Links

Links to other databases for N-acetyl-L-glutamic acid

ChEBI
PubChem
ChEBI
PubChem