Ligand dTDP

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Basic Ligand Information

Molecular Structure

C₁₀H₁₆N₂O₁₁P₂

dTDP

UJLXYODCHAELLY-XLPZGREQSA-N

Synonyms:

2'-dTDP, 5'-dTDP, D-2'-dTDP, D-dTDP, TDP, Thymidine 5'-diphosphate, thymidine diphosphate

BRENDA

aclacinomycin biosynthesis, daunorubicin biosynthesis, elloramycin biosynthesis, ginsenoside metabolism, macrolide antibiotic biosynthesis

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KEGG

Nucleotide metabolism, Pyrimidine metabolism

MetaCyc

acetan biosynthesis, aclacinomycin biosynthesis, clorobiocin biosynthesis, daunorubicin biosynthesis, dimycocerosyl triglycosyl phenolphthiocerol biosynthesis

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Show all BRENDA pathways known for dTDP

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (24 results)

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2.7.1.40

TDP + phosphoenolpyruvate = TTP + pyruvate

737796

2.7.4.1

TDP + (phosphate)n+1 = TTP + (phosphate)n

645125

2.7.4.3

ADP + TDP = AMP + TTP

TDP + H2O = TMP + phosphate

696275

In Vivo Product in Enzyme-catalyzed Reactions (65 results)

dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + 3-alpha-mycarosylerythronolide B = dTDP + erythromycin D

2.4.1.289

dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = dTDP + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol

2.4.1.302

dTDP-beta-L-noviose + novobiocic acid = dTDP + demethyldecarbamoyl novobiocin

2.4.1.311

dTDP-beta-L-4-epi-vancosamine + devancosaminyl-vancomycin = dTDP + chloroorienticin B

2.4.1.316

tylactone + dTDP-alpha-D-mycaminose = dTDP + 5-O-beta-D-mycaminosyltylactone

2.4.1.317

5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose = dTDP + demethyllactenocin

2.4.1.318

dTDP-beta-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin

2.4.1.322

dTDP-beta-L-vancosamine + devancosaminyl-vancomycin = dTDP + vancomycin

2.4.1.325

dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = dTDP + 4-acetamido-4,6-dideoxy-alpha-D-galactosyl-(1->4)-N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol

2.4.1.326

2 entries

2.4.1.327

dTDP-2-deoxy-beta-L-fucose + aclacinomycin T = dTDP + aclacinomycin S

2.4.1.328

2 entries

2.4.1.331

dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C = dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C

2.4.1.B46

dTDP-2-deoxy-beta-L-fucose + 4-O-(alpha-L-rhodosaminyl)aklavinone = dTDP + 4-O-[(4-O-2-deoxy-alpha-L-fucosyl)-alpha-L-rhodosaminyl]aklavinone

2.7.1.21

ATP + thymidine 5'-phosphate = ADP + thymidine diphosphate

2.7.4.13

ATP + dTMP = ADP + dTDP

2.7.4.4

ATP + TMP = ADP + TDP

dTTP + H2O = dTDP + phosphate

0, 210044, 210046

Substrate in Enzyme-catalyzed Reactions (56 results)

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2.4.1.13

dTDP + sucrose = dTDP-alpha-D-glucose + D-fructose

756234

2.7.1.147

TDP + D-glucose = TMP + D-glucose 6-phosphate

TDP + phosphoramide = TTP + NH3

642495

2.7.4.1

TDP + (phosphate)n+1 = TTP + (phosphate)n

645125

2.7.4.3

ADP + TDP = AMP + TTP

dTDP + (phosphate)n+1 = dTTP + (phosphate)n

762661

3.1.3.2

TDP + H2O = TMP + phosphate

134695, 134688, 134689

3.6.1.15

TDP + H2O = TMP + phosphate

696275

3.6.1.29

adenosine 5'-phosphoimidazolide + TDP = imidazole + A(5')p3(5')T

655798

3.6.1.5

TDP + H2O = TMP + phosphate

210165, 210149, 720261, 655463

TDP + H2O = ?

dTDP + H2O = ?

Product in Enzyme-catalyzed Reactions (361 results)

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2.4.1.11

dTDP-glucose + (1,4-alpha-D-glucosyl)n = dTDP + (1,4-alpha-D-glucosyl)n+1

2.4.1.118

6 entries

2.4.1.120

dTDP-alpha-D-glucose + sinapic acid = dTDP + 1-O-sinapoyl-beta-D-glucose

TDP-glucose + N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R = TDP + ?

2.4.1.186

2 entries

2.4.1.218

TDP-glucose + hydroquinone = TDP + hydroquinone-O-beta-D-glucopyranoside

2.4.1.239

TDP-glucose + a flavonol 3-O-beta-D-glucoside = TDP + a flavonol 3-O-beta-D-glucosyl-(1-2)-beta-D-glucoside

2.4.1.240

TDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1-2)-beta-D-glucoside = TDP + a flavonol 3-O-beta-D-glucosyl-(1-2)-beta-D-glucosyl-(1-2)-beta-D-glucoside

2.4.1.242

dTDP-glucose + (1,4-alpha-D-glucosyl)n = dTDP + (1,4-alpha-D-glucosyl)n+1

2.4.1.266

TDP-glucose + 3-phospho-D-glycerate = TDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = dTDP + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol

5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose = dTDP + demethyllactenocin

2.4.1.318

dTDP-beta-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin

dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C = dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C

2.4.1.338

TDP-alpha-D-glucose + validoxylamine A = TDP + validamycin A

dTDP-beta-L-rhamnose + alpha-D-galactosyl-diphospho-ditrans,octacis-undecaprenol = dTDP + alpha-L-Rha-(1->3)-alpha-D-Gal-PP-undecaprenol

2.4.1.381

dTDP-beta-L-rhamnose + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-undecaprenol = dTDP + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-undecaprenol

2.4.1.384

7 entries

2.4.1.52

dTDP-glucose + poly(glycerophosphate) = dTDP + alpha-D-glucosyl-poly(glycerol phosphate)

2.4.1.66

TDP-glucose + D-galactosylhydroxylysine = TDP + 1,2-D-glucosyl-D-galactosylhydroxylysine

636787

2.4.1.71

TDP-glucose + an arylamine = TDP + an N-D-glucosylarylamine

489371

2.4.1.80

TDP-glucose + N-acylsphingosine = TDP + D-glucosyl-N-acylsphingosine

dTDP-L-dihydrostreptose + streptidine 6-phosphate = dTDP + O-alpha-L-dihydrostreptosyl-1,4-streptidine 6-phosphate

637788

2.7.1.1

TTP + D-glucose = TDP + D-glucose 6-phosphate

2.7.1.11

TTP + D-fructose 6-phosphate = TDP + D-fructose 1,6-bisphosphate

640421, 640511

2.7.1.113

dTTP + deoxyguanosine = dTDP + dGMP

640551, 640549, 640553

2.7.1.144

TTP + D-tagatose 6-phosphate = TDP + D-tagatose 1,6-bisphosphate

2.7.1.165

TTP + (R)-glycerate = TDP + 2-phospho-(R)-glycerate

2.7.1.20

TTP + adenosine = TDP + AMP

TTP + 3'-dephospho-CoA = TDP + CoA

2.7.1.30

TTP + glycerol = TDP + glycerol 3-phosphate

2.7.1.33

pantothenate + dTTP = 4'-phosphopantothenate + dTDP

2.7.1.36

2 entries

2.7.1.4

TTP + D-fructose = TDP + D-fructose 6-phosphate

2.7.1.45

TTP + 2-dehydro-3-deoxy-D-gluconate = TDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

2.7.1.48

dTTP + uridine = dTDP + UMP

641643

2.7.1.50

TTP + 4-methyl-5-(2-hydroxyethyl)thiazole = TDP + 4-methyl-5-(2-phosphonooxyethyl)thiazole

2.7.1.56

TTP + D-fructose 1-phosphate = TDP + D-fructose 1,6-bisphosphate

640483, 0

2.7.1.63

TTP + glucose = TDP + D-glucose 6-phosphate

2.7.1.67

TTP + 1-phosphatidyl-1D-myo-inositol = TDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

2.7.1.7

TTP + D-mannose = TDP + D-mannose 6-phosphate

TTP + 5'-dephospho-DNA = TDP + 5'-phospho-DNA

642004

2.7.1.B20

TTP + inosine = TDP + inosine 5'-phosphate

2.7.2.1

TTP + acetate = TDP + acetyl phosphate

642178, 642184, 0

2.7.2.3

2'-dTTP + 3-phospho-D-glycerate = 2'-dTDP + 3-phospho-D-glyceroyl phosphate

2.7.4.12

2 entries

2.7.4.13

ATP + dTMP = ADP + dTDP

0, 642542, 642544

2.7.4.14

4 entries

2.7.4.2

TTP + (R,S)-5-phosphomevalonate = TDP + (R,S)-5-diphosphomevalonate

2.7.4.3

3 entries

2.7.4.33

TMP + [phosphate]n = TDP + [phosphate]n-1

2.7.4.4

ATP + TMP = ADP + TDP

dTTP + (phosphate)n = dTDP + (phosphate)n+1

dTTP + H2O = dTDP + phosphate

3.6.1.15

4 entries

3.6.1.39

dTTP + H2O = dTDP + phosphate

0, 210044, 210046

3.6.1.5

TTP + H2O = TDP + phosphate

3.6.1.66

dITP + H2O = dTDP + phosphate

3.6.1.9

TTP + H2O = TDP + phosphate

3.6.4.13

dTTP + H2O = dTDP + phosphate

4.1.1.49

TTP + oxaloacetate = TDP + phosphoenolpyruvate + CO2

5.6.1.2

TTP + H2O + a dynein associated with a microtubule at position n = TDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)

247009, 247007

5.6.1.5

TTP + H2O + polypeptide = TDP + phosphate + unfolded polypeptide