Ligand decanoyl-CoA

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Basic Ligand Information

Molecular Structure
Picture of decanoyl-CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C31H54N7O17P3S
decanoyl-CoA
CNKJPHSEFDPYDB-HSJNEKGZSA-N
Synonyms:
n-decanoyl-CoA

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
decanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxolauroyl-[acyl-carrier protein] + CoA + CO2
show the reaction diagram
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decanoyl-CoA + H2O = decanoate + CoA
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Substrate in Enzyme-catalyzed Reactions (63 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
decanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydecanoyl-CoA + succinate + CO2
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decanoyl-CoA + NAD(P)H = decanal + NAD(P)+
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decanoyl-CoA + 2 NADPH + 2 H+ = decanol + 2 NADP+ + coenzyme A
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decanoyl-CoA + NADPH + H+ = ?
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decanoyl-CoA + O2 = trans-2-decenoyl-CoA + H2O2
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n-decanoyl-CoA + sn-glycerol 3-phosphate = CoA + 1-n-decanoyl-sn-glycerol 3-phosphate
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decanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-lauroyl-[acyl-carrier protein] + CoA + CO2
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decanoyl-CoA + malonyl-CoA = ?
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decanoyl-CoA + 1,2-diacylglycerol = CoA + 1,2-diacyl-3-decanoylglycerol
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decanoyl-CoA + L-carnitine = CoA + L-decanoylcarnitine
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decanoyl-CoA + 2-oleoylglycerol = ?
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decanoyl-CoA + [Wnt]-L-serine = CoA + [Wnt]-O-decanoyl-L-serine
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decanoyl-CoA = 4-hydroxy-6-octyl-2H-pyran-2-one + 4-hydroxy-6-(2-oxoundecyl)-2H-pyran-2-one + 4-hydroxyl-6-(2',4',6'-trioxopentadecyl)-2-pyrone + CO2 + CoA
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decanoyl-CoA + malonyl-CoA = 1-(2,4,6-trihydroxyphenyl)-decan-1-one + CoA + CO2
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decanoyl-CoA + malonyl-CoA + NADPH + H+ = ?
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n-decanoyl-CoA + glycylpeptide = N-decanoylglycylpeptide + CoA
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decanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxydodecane-1,2,3-tricarboxylate + CoA
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decanoyl-CoA + H2O = ?
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decanoyl-CoA + H2O + 2-oxoglutarate = (3S,4S)-3-hydroxydodecane-1,3,4-tricarboxylate + CoA
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decanoyl-CoA + apo-[acyl-carrier protein] = ? + holo-[acyl-carrier protein]
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decanoyl-CoA = decanoate + CoA
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decanoyl-CoA + H2O = CoA + decanoate
show the reaction diagram
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decanoyl-CoA + H2O = decanoate + CoA
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
decanoic acid + ATP + CoA = decanoyl-CoA + AMP + diphosphate
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trans-2-decenoyl-CoA + NADH + H+ = decanoyl-CoA + NAD+
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cis-2-decenoyl-CoA + NADPH + H+ = decanoyl-CoA + NADP+
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trans-2-decenoyl-CoA + NADPH = decanoyl-CoA + NADP+
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2-trans-decenoyl-CoA + NAD(P)H = decanoyl-CoA + NADP+
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decanoyl-L-carnitine + CoA = decanoyl-CoA + L-carnitine
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3-oxododecanoyl-CoA + CoA = acetyl-CoA + decanoyl-CoA
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decanoylcarnitine + CoASH = decanoyl-CoA + carnitine
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ATP + n-decanoate + CoA = AMP + diphosphate + n-decanoyl-CoA
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ATP + decanoate + CoA = AMP + diphosphate + decanoyl-CoA
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ATP + decanoate + CoA = AMP + diphosphate + decanoyl-CoA
show the reaction diagram
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decanoic acid + CoA + ATP = decanoyl-CoA + AMP + diphosphate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
about 15% inhibition at 0.2 mM
-
IC50 is 0.004 mM
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functions as acyl donor at low concentration with inhibition of acylation at higher concentrations
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noncompetitive inhibition
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0.1 mM, 79% inhibition
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non-competitive substrate inhibition at higher substrate concentrations
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (25 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.53
-
recombinant enzyme
2.25
-
-
0.044
-
pH 8.0, 30°C
32.8
-
wild type enzyme, at pH 7.6 and 21°C

KM Value (69 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.83
-
in 10 mM Tris/maleic acid pH 6.7, 0.65 M mannitol and 0.36 mM EGTA, at 30°C
0.011
-
pH 8.0, 30°C
0.83
-
-

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.063
-
-
0.9
-
at pH 7.5 and 30°C
0.0027
-
pH 8.0
0.05
-
pH 6.0, 30°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.004
-
IC50 is 0.004 mM

References & Links

Links to other databases for decanoyl-CoA

ChEBI
PubChem
ChEBI
PubChem