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BRENDA support

Ligand diosgenin

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Basic Ligand Information

Molecular Structure
Picture of diosgenin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C27H42O3
diosgenin
WQLVFSAGQJTQCK-VKROHFNGSA-N
Synonyms:
(3beta,25R)-spirost-5-en-3-ol, (25R)-spirost-5-en-3beta,25beta-diol, (25R)-spirost-5-en-3beta-ol, 25R-Spirost-5-en-3beta-ol
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
diosgenin + O2 = ? + H2O2
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-O-[alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc]diosgenin + 3 H2O = D-glucopyranose + 2 L-rhamnopyranose + diosgenin
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(25R)-spirost-5-en-3beta-ol + UDP-glucose = UDP + (25R)-spirost-5-en-3beta-ol 3-O-beta-D-glucoside
show the reaction diagram
-
UDPglucose + (25R)-spirost-5-en-3beta-ol = UDP + (25R)-spirost-5-en-3beta-ol 3-O-beta-D-glucoside
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
10 microM increases cyclooxygenase-2 and thromboxane synthase expression and activities in HEL cells, 3.5fold at 96 h and 4.5fold at 144 h
-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.079, 50% inhibition
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.0023
-
for the cytosolic enzyme

KM Value (5 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.002
-
for the cytosolic enzyme

References & Links

Links to other databases for diosgenin

ChEBI
PubChem
ChEBI
PubChem