print visible entries

print all entries

Ligand 10-formyltetrahydrofolate

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

histidine metabolism, purine metabolism, reductive acetyl coenzyme A pathway, tetrahydrofolate metabolism

KEGG

Aminoacyl-tRNA biosynthesis, Antifolate resistance, Biosynthesis of cofactors, Carbon fixation pathways in prokaryotes, Carbon metabolism, Microbial metabolism in diverse environments, One carbon pool by folate more

MetaCyc

5-aminoimidazole ribonucleotide biosynthesis I, antimycin biosynthesis, folate polyglutamylation, folate transformations I, folate transformations II (plants), folate transformations III (E. coli), formaldehyde oxidation VII (THF pathway), formate assimilation into 5,10-methylenetetrahydrofolate, GDP-N-formyl-alpha-D-perosamine biosynthesis, inosine-5'-phosphate biosynthesis I, inosine-5'-phosphate biosynthesis II, L-histidine degradation III, L-phenylalanine degradation V, polymyxin resistance, purine nucleobases degradation I (anaerobic), purine nucleobases degradation II (anaerobic), pyoverdine I biosynthesis, reductive acetyl coenzyme A pathway I (homoacetogenic bacteria), reductive glycine pathway of autotrophic CO2 fixation, tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate more

Show all BRENDA pathways known for 10-formyltetrahydrofolate

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (15 results)

top print hide

Show Natural Substrate (15 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.5.1.6

10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH + H+

724712, 392340, 392350, 392343, 392349, 392351, 392345, 392348, 392352, 392339, 392344, 392354, 392355, 392337

-

2.1.2.13

10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose

698723, 758290, 696208, 698730, 698732

-

2.1.2.14

10-formyltetrahydrofolate + GDP-alpha-D-perosamine = tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine

760585, 762368

-

2.1.2.2

10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide = tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide

485727, 485712, 485713, 485714, 485716, 485718, 485736, 485715, 485729, 485734, 485717, 485737, 485739, 485711, 172166, 1312, 485724, 485721, 485725, 485728, 485731, 485735, 485738, 1413, 485719, 485720, 485740, 485741, 485742

-

2.1.2.2

10-formyltetrahydrofolate + glycinamide ribonucleotide = tetrahydrofolate + formylglycinamide ribonucleotide

485715, 485717

-

2.1.2.2

10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide

756039, 756648, 758344

-

2.1.2.3

10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide = tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide

658026

-

2.1.2.3

10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide = tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide

658284, 658026, 657946, 659419, 652530, 659681

-

2.1.2.3

10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide = tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide

172163, 485754, 485757, 172161, 485747, 485749, 485750, 485744, 485745, 485756, 485758, 485746, 485742, 485759, 485760, 485755, 485753, 485748

-

2.1.2.3

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

757625, 673127, 756109, 756643, 756648, 756196, 757213, 689976, 736802, 757016, 757394, 756701

-

2.1.2.9

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O = tetrahydrofolate + N-formylmethionyl-tRNAfMet

485798, 485795, 485796, 485797, 485802, 485809, 485810, 485811, 485812, 485815, 485800, 485804, 485813, 485805, 485806, 659462, 657992, 673867

-

2.1.2.9

10-formyltetrahydrofolate + L-methionyl-tRNAfMet = tetrahydrofolate + N-formylmethionyl-tRNAfMet

735441, 719239, 757809, 756708, 720491, 736461

-

2.1.2.2

3 entries

2.1.2.3

4 entries

2.1.2.9

2 entries

3.5.1.10

10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate

208967

-

3.5.4.9

10-formyltetrahydrofolate = 5,10-methenyltetrahydrofolate + H2O

392333, 209722, 209726, 209728, 209719

-

6.3.4.3

ADP + phosphate + 10-formyltetrahydrofolate = ?

1516

-

In Vivo Product in Enzyme-catalyzed Reactions (9 results)

top print hide

Show Natural Product (9 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.5.1.3

10-formyl-dihydrofolate + NADPH + H+ = 10-formyl-tetrahydrofolate + NADP+

0

-

2.1.2.3

tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

0

-

3.5.4.9

5,10-methenyl-tetrahydrofolate + H2O = 10-formyltetrahydrofolate + H+

0

-

3.5.4.9

5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate

0

-

3.5.4.9

5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate + ?

0

-

3.5.4.9

N5,N10-methenyltetrahydrofolate + H2O = N10-formyltetrahydrofolate

0

-

6.3.4.3

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate

0, 650869, 650943, 651414, 649471, 652471, 649939, 649968, 651731

-

6.3.4.3

formate + ATP + tetrahydrofolate = 10-formyltetrahydrofolate + ADP + phosphate

0

-

6.3.4.3

tetrahydrofolate + formate + ATP = 10-formyltetrahydrofolate + ADP + phosphate

0

-

3.5.4.9

4 entries

6.3.4.3

3 entries

Substrate in Enzyme-catalyzed Reactions (50 results)

top print hide

Show Substrate (50 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.5.1.6

10-formyltetrahydrofolate + NADP+ + H2O = ?

656137

-

1.5.1.6

10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH + H+

392340, 392350, 392355, 656770, 724712, 392347, 392351, 392352, 674389, 685138, 687640, 392343, 392342, 392349, 713460, 392339, 392345, 392346, 392344, 392348, 392353, 392335, 392336, 392341, 392337, 392338, 392354

-

1.5.1.6

2 entries

2.1.2.13

10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose

698723, 758290, 696208, 698730, 698732

-

2.1.2.14

10-formyltetrahydrofolate + GDP-3-deoxyperosamine = tetrahydrofolate + GDP-N-formyl-3-deoxyperosamine

760585

-

2.1.2.14

10-formyltetrahydrofolate + GDP-alpha-D-perosamine = tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine

760585, 762368

-

2.1.2.2

10-formyltetrahydrofolate + (alpha,beta)-glycinamide ribonucleotide = tetrahydrofolate + formylglycinamide ribonucleotide

485738

-

2.1.2.2

10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide = tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide

485727, 1312, 172166, 485712, 485713, 485714, 485716, 485718, 485721, 485724, 485725, 485728, 485729, 485731, 485734, 485735, 485738, 485742, 485715, 485736, 1413, 485717, 485719, 485737, 485739, 485720, 485730, 485732, 485733, 485740, 485741, 485711

-

2.1.2.2

10-formyltetrahydrofolate + beta-5-phospho-D-ribosylglycinamide = tetrahydrofolate + beta-5'-phosphoribosyl-N-formylglycinamide

485718, 485727

-

2.1.2.2

10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide = tetrahydrofolate + formyl glycinamide ribonucleotide

485725, 485735, 485738, 1413

-

2.1.2.2

10-formyltetrahydrofolate + glycinamide ribonucleotide = tetrahydrofolate + formylglycinamide ribonucleotide

485715, 485717

-

2.1.2.2

10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide

688289, 685128, 688291, 756039, 756648, 735672, 758344

-

2.1.2.2

10-formyltetrahydrofolate + N5-hydroxyornithine = tetrahydrofolate + N5-formyl-N5-hydroxyornithine

485736

-

2.1.2.2

10-formyltetrahydrofolate + O-phosphonate carbocyclic glycinamide ribonucleotide = tetrahydrofolate + O-phosphonate-ribosyl-N-formylglycinamide

485735

-

2.1.2.2

beta-glycinamide ribonucleotide + 10-formyltetrahydrofolate = ?

685128

-

2.1.2.3

(6R,6S)-10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide = tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide

172163

-

2.1.2.3

10-formyl-tetrahydrofolic acid + 5'-phosphoribosyl-5-amino-imidazole-carboxamide = 5,6,7,8-tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide

702155

-

2.1.2.3

10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide = tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide

658026, 702155

-

2.1.2.3

10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide = tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide

658284, 658026, 657946, 659419, 652530, 659681

-

2.1.2.3

10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide = tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide

172163, 485754, 485757, 172161, 485747, 485749, 485750, 485744, 485745, 485756, 485758, 485746, 485742, 485759, 485760, 485755, 485753, 485748

-

2.1.2.3

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

757625, 673127, 756109, 756643, 756648, 719415, 756196, 757213, 689976, 736802, 757016, 757394, 756701

-

2.1.2.3

10-formyltetrahydrofolate + 5-amino-imidazole-4-thiocarboxamide ribonucleotide = tetrahydrofolate + 6-mercaptopurine ribonucleotide

485756

-

2.1.2.3

N10-formyltetrahydropteroylmonoglutamate + 5'-phosphoribosyl-5-formamino-4-imidazole carboxamide ribonucleotide = tetrahydropteroylmonoglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide

485746

-

2.1.2.9

10-formyltetrahydrofolate + bovine mitochondrial L-methionyl-tRNA = tetrahydrofolate + bovine mitochondrial N-formylmethionyl-tRNA

485807

-

2.1.2.9

10-formyltetrahydrofolate + E. coli L-isoleucyl-tRNAfMet = tetrahydrofolate + E. coli N-formylisoleucyl-tRNAfMet

485813, 485808

-

2.1.2.9

10-formyltetrahydrofolate + E. coli L-methionyl-tRNA1Val(CAU) = tetrahydrofolate + E. coli N-formylisoleucyl-tRNA1Val(CAU)

485808

-

2.1.2.9

10-formyltetrahydrofolate + E. coli L-methionyl-tRNAfMet = tetrahydrofolate + E. coli N-formylmethionyl-tRNAfMet

485813, 485807, 485808, 485812

-

2.1.2.9

10-formyltetrahydrofolate + E. coli L-methionyl-tRNAfMet = tetrahydrofolate + N-formylmethionyl-tRNAfMet

485814, 485813, 485808

-

2.1.2.9

10-formyltetrahydrofolate + E. coli L-methionyl-tRNAmMet = tetrahydrofolate + E. coli N-formylmethionyl-tRNAmMet

485807, 485808

-

2.1.2.9

10-formyltetrahydrofolate + E. coli L-methionyl-tRNAmMet = tetrahydrofolate + N-formylmethionyl-tRNAmMet

485808

-

2.1.2.9

10-formyltetrahydrofolate + E. coli L-valyl-tRNAfMet = tetrahydrofolate + E. coli N-formylvalyl-tRNAfMet

485813, 485808

-

2.1.2.9

10-formyltetrahydrofolate + E. coli L-valyl-tRNAfMet = tetrahydrofolate + N-formylvalyl-tRNAfMet

485813

-

2.1.2.9

10-formyltetrahydrofolate + E.coli L-methionyl-tRNAfMet = tetrahydrofolate + E.coli N-formylmethionyl-tRNAfMet

485814

-

2.1.2.9

10-formyltetrahydrofolate + isoleucyl-tRNAfMet + H2O = tetrahydrofolate + N-formylisoleucyl-tRNAfMet

485813, 485808

-

2.1.2.9

10-formyltetrahydrofolate + L-isoleucyl-tRNAfMet = tetrahydrofolate + N-formylisoleucyl-tRNAfMet

485813

-

2.1.2.9

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O = tetrahydrofolate + N-formylmethionyl-tRNAfMet

661778, 673867, 485813, 485800, 485815, 485812, 485807, 485808, 485802, 485804, 485798, 485799, 485811, 485795, 485797, 485814, 485794, 485796, 485810, 485801, 485806, 485809, 485805, 659462, 657992

-

2.1.2.9

10-formyltetrahydrofolate + L-methionyl-tRNAfMet = tetrahydrofolate + N-formylmethionyl-tRNAfMet

735441, 485795, 485796, 485797, 485799, 485809, 485810, 485811, 719239, 757809, 756708, 485802, 720491, 736461, 485812

-

2.1.2.9

10-formyltetrahydrofolate + L-methionyl-tRNAMet = tetrahydrofolate + N-formylmethionyl-tRNAMet

485794

-

2.1.2.9

10-formyltetrahydrofolate + L-phenylalanyl-tRNAfMet + H2O = tetrahydrofolate + N-formylphenylalanyl-tRNAfMet

657992

-

2.1.2.9

10-formyltetrahydrofolate + methionyl-tRNA1Val(CAU) + H2O = tetrahydrofolate + N-formylmethionyl-tRNA1Val(CAU)

485808

-

2.1.2.9

10-formyltetrahydrofolate + methionyl-tRNAmMet + H2O = tetrahydrofolate + N-formylmethionyl-tRNAmMet

485808

-

2.1.2.9

10-formyltetrahydrofolate + phenylalanyl-tRNAfMet + H2O = tetrahydrofolate + N-formylphenylalanyl-tRNAfMet

485796, 485798

-

2.1.2.9

10-formyltetrahydrofolate + valyl-tRNAfMet + H2O = tetrahydrofolate + N-formylvalyl-tRNAfMet

485796, 485798, 485813, 485808

-

2.1.2.14

2 entries

2.1.2.2

9 entries

2.1.2.3

8 entries

2.1.2.9

20 entries

3.5.1.10

10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate

392346, 208967, 208968

-

3.5.4.9

10-formyltetrahydrofolate = 5,10-methenyltetrahydrofolate + H2O

392333, 209722, 209726, 209728, 209719, 654529

-

6.3.2.17

ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + Glu = ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glu2

671052

-

6.3.2.17

ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + Glu = ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2

1081, 1006, 1063, 1076, 1070, 1059, 1061, 1009, 1075, 1078

-

6.3.2.17

ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + L-glutamate = ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glu2

1091

-

6.3.2.17

ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + L-glutamate = ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2

1089

-

6.3.2.17

ATP + 10-formyl-5,6,7,8-tetrahydropteroylglutamate + L-glutamate = ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2

653665

-

6.3.2.17

5 entries

6.3.4.3

ADP + phosphate + 10-formyltetrahydrofolate = ?

1516

-

Product in Enzyme-catalyzed Reactions (15 results)

top print hide

Show Product (15 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.5.1.3

10-formyl-dihydrofolate + NADPH + H+ = 10-formyl-tetrahydrofolate + NADP+

0

-

1.5.1.6

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate

0

-

2.1.2.2

N5,N10-anhydroformyltetrahydrofolate + glycinamide ribotide + H2O = N10-formyltetrahydrofolate + formylglycinamide ribotide

0

-

2.1.2.3

tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

0

-

3.5.4.9

(6R,S)-5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate

0

-

3.5.4.9

5,10-methenyl-tetrahydrofolate + H2O = 10-formyltetrahydrofolate + H+

0

-

3.5.4.9

5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate

0

-

3.5.4.9

5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate + ?

0

-

3.5.4.9

N5,N10-methenyltetrahydrofolate + H2O = N10-formyltetrahydrofolate

0

-

6.3.4.3

ATP + formate + (6R,S)-5,6,7,8-tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate

0

-

6.3.4.3

ATP + formate + (6R,S)-tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate

0

-

6.3.4.3

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate

1506, 1504, 1530, 0, 1522, 650869, 650943, 651414, 1505, 1526, 1503, 1529, 1519, 1520, 1518, 1528, 1510, 1511, 1512, 1514, 1515, 1521, 1523, 1524, 1516, 1517, 1531, 1502, 1507, 1525, 1527, 649471, 1509, 651731, 652471, 649939, 649968, 1508, 1513

-

6.3.4.3

dATP + formate + tetrahydrofolate = dADP + phosphate + 10-formyltetrahydrofolate

0

-

6.3.4.3

formate + ATP + tetrahydrofolate = 10-formyltetrahydrofolate + ADP + phosphate

0

-

6.3.4.3

tetrahydrofolate + formate + ATP = 10-formyltetrahydrofolate + ADP + phosphate

0

-

3.5.4.9

5 entries

6.3.4.3

6 entries

Enzyme Cofactor/Cosubstrate (12 results)

top print hide

Show Cofactor (12 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.5.1.6

10-formyltetrahydrofolate

392340, 392348, 392350, 392355, 392335, 392336, 392339, 392341, 392342, 392343, 392345, 392346, 392347, 392351, 392352, 392353, 392337, 392338, 392344, 392349

-

1.5.1.6

10-formyltetrahydrofolate as coenzyme

392354

-

1.5.1.6

10-formyltetrahydrofolate is one of the most labile of the reduced coenzymes

392351

-

1.5.1.6

pentaglutamate form as coenzyme is very tightly bound to enzyme

392349

-

2.1.2.2

binding structure and formyl transfer structure and mechanism analysis, overview

735672

-

2.1.2.2

-

485714, 485718

-

2.1.2.2

-

172166, 485727, 485729

-

2.1.2.2

only formyldonor

485727

-

2.1.2.3

-

658026, 658284, 673127, 689976, 657946, 659419, 652530, 659681, 736802

-

2.1.2.3

-

718506, 485756, 485759, 485760, 485745, 485747

-

2.1.2.9

-

735441, 485794, 485796, 485798, 485799, 485802, 485804, 485800, 485801, 736461

-

2.1.2.9

1.1 mol 10-L-formyltetrahydrofolate is bound per mol monomeric enzyme

485795, 485797

-

1.5.1.6

4 entries

2.1.2.2

4 entries

2.1.2.3

2 entries

2.1.2.9

2 entries

Inhibitor in Enzyme-catalyzed Reactions (4 results)

top print hide

Show Inhibitors (4 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.5.1.5

-

392307, 392308

-

2.1.1.45

-

485398

-

2.1.1.45

-

485398

-

2.1.1.45

-

485398

-

2.1.1.45

3 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (4 results)

top print hide

Show Turnover Number (4 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.5.1.6

0.967

-

-

392344

1.5.1.6

1

-

-

392337

1.5.1.6

97

-

30°C, pH not specified in the publication, full-length recombinant enzyme

713460

1.5.1.6

3 entries

2.1.2.3

4.97

-

pH 7.5, temperature not specified in the publication

757625

K_M Value (55 results)

top print hide

Show KM Value (55 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.5.1.6

0.0044

-

racemic, fluorimetric assay

392337

1.5.1.6

0.0045

-

at pH 7

392341

1.5.1.6

0.0055

-

-

392351

1.5.1.6

0.007

-

-

392339

1.5.1.6

0.0075

-

racemic, spectrophotometric assay

392337

1.5.1.6

0.0082

-

(-)-isomer

392335

1.5.1.6

0.0114

-

at pH 7.0 and 30°C

724712

1.5.1.6

0.0127

-

30°C, pH not specified in the publication, recombinant N-terminal domain

713460

1.5.1.6

0.013

-

-

392344

1.5.1.6

0.0156

-

30°C, pH not specified in the publication, full-length recombinant enzyme

713460

1.5.1.6

0.017

-

racemic

392336

1.5.1.6

0.02

-

-

392340

1.5.1.6

0.05

-

-

392340

2.1.2.2

0.0008

-

-

485724

2.1.2.2

0.00594

-

in absence of trifunctional protein

485714

2.1.2.2

0.00676

-

-

485714

2.1.2.3

0.00165

-

25 mM KCl

485746

2.1.2.3

0.0043

-

mutant K266R

485757

2.1.2.3

0.0076

-

wild-type

485757

2.1.2.3

0.01

-

-

485759

2.1.2.3

0.0602

-

-

172163

2.1.2.3

0.0679

-

-

485748

2.1.2.3

0.111

-

pH 7.5, temperature not specified in the publication

757625

2.1.2.3

0.13437

-

AICAR transformylase activity of domain truncation mutant pET-28c-AICARTF1, pH 7.4, temperature not specified in the publication

756701

2.1.2.3

0.138

-

full length bifunctional AICAR transformylase/IMP cyclohydrolase (ATIC), pH 7.4, temperature not specified in the publication

756701

2.1.2.3

0.13824

-

at pH 7.4, temperature not specified in the publication

756701

2.1.2.3

0.2

-

-

485745

2.1.2.3

0.353

-

150 mM KCl

485746

2.1.2.9

0.006

0.007

-

485802

2.1.2.9

0.0133

-

-

485794

2.1.2.9

0.0135

-

-

485795, 485797

3.5.1.10

0.007

-

30°C, pH 7.8, wild type

392346

3.5.1.10

0.0083

-

30°C, pH 7.8, H125A mutant

392346

3.5.1.10

0.009

-

30°C, pH 7.8, H113A mutant

392346

3.5.1.10

0.0095

-

30°C, pH 7.8, H100A mutant

392346

3.5.1.10

0.049

-

2.0 mM methionine added

208968

3.5.4.9

0.009

-

pH 7.0, 23°C

654529

3.5.4.9

0.016

-

reverse reaction, recombinant mutant S197D, substrate 10-formyltetrahydrofolate

654797

3.5.4.9

0.018

-

reverse reaction, recombinant mutant R173K, substrate 10-formyltetrahydrofolate

654797

3.5.4.9

0.02

-

reverse reaction, recombinant mutant S197T, substrate 10-formyltetrahydrofolate

654797

3.5.4.9

0.024

-

reverse reaction, recombinant mutant R173A, substrate 10-formyltetrahydrofolate

654797

3.5.4.9

0.026

-

reverse reaction, recombinant wild-type enzyme, substrate 10-formyltetrahydrofolate

654797

3.5.4.9

0.028

-

reverse reaction, recombinant mutant S197R, substrate 10-formyltetrahydrofolate

654797

3.5.4.9

0.031

-

reverse reaction, recombinant mutant R173E, substrate 10-formyltetrahydrofolate

654797

3.5.4.9

0.043

-

reverse reaction, recombinant mutant S197A, substrate 10-formyltetrahydrofolate

654797

3.5.4.9

0.056

-

-

392333

3.5.4.9

0.07

-

-

1505, 209722

3.5.4.9

0.1

-

-

209722

3.5.4.9

0.2

-

-

209728

3.5.4.9

0.47

-

-

209722

6.3.2.17

0.0022

-

-

1061, 1063

6.3.2.17

0.0037

-

-

1089, 1091

6.3.2.17

0.0039

-

-

1081

6.3.2.17

0.014

-

-

1006

1.5.1.6

13 entries

2.1.2.2

3 entries

2.1.2.3

12 entries

2.1.2.9

3 entries

3.5.1.10

5 entries

3.5.4.9

14 entries

6.3.2.17

4 entries

6.3.4.3

10

-

-

1506

K_i Value (2 results)

top print hide

Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.5.1.5

0.07

-

-

392307

2.1.1.45

0.02

-

-

485398

References & Links

Literature References (206)

top print hide

Show Reference (206 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

1006

2985605

Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase. Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product

1985

Bognar, A.L.; Osborne, C.; Shane, B.; Singer, S.C.; Ferone, R.

J. Biol. Chem.

260

5625-5630

1009

6412521

Folylpoly-gamma-glutamate synthetases: properties and regulation

1983

Shane, B.; Cichowicz, D.J.

Adv. Exp. Med. Biol.

163

149-165

1059

3828323

Mammalian folylpoly-gamma-glutamate synthetase. 4. In vitro and in vivo metabolism of folates and analogues and regulation of folate homeostasis

1987

Cook, J.D.; Cichowicz, D.J.; George, S.; Lawler, A.; Shane, B.

Biochemistry

26

530-539

1061

3828321

Mammalian folylpoly-gamma-glutamate synthetase. 2. Substrate specificity and kinetic properties

1987

Cichowicz, D.J.; Shane, B.

Biochemistry

26

513-521

1063

-

Folylpoly-gamma-glutamate synthetase

1986

Shane, B.

Chem. Biol. Pteridines, Proc. Int. Symp. Pteridines Folic Acid Deriv. Chem. Biol. Clin. Aspects

-

719-728

1070

-

Studies on the substrate specificity of mammalian folylpolyglutamate synthetase

1982

McGuire, J.J.; Hsieh, P.; Bertino, J.R.; Coward, J.K.

Chem. Biol. Pteridines, Proc. Int. Symp. Pteridines Folic Acid Deriv. Chem. Biol. Clin. Aspects

-

615-619

1075

-

Corynebacterium species folylpoly-gamma-glutamate synthetase

1982

Shane, B.

Pept. Antibiot. Biosynth. Funct. (Kleinkauf H. et al. eds. )

-

353-368

1076

6458762

Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells

1981

Cichowicz, D.J.; Foo, S.K.; Shane, B.

Mol. Cell. Biochem.

39

209-228

1078

6892912

Pteroylpoly(gamma-glutamate) synthesis by Corynebacterium species. Purification and properties of folylpoly(gamma-glutamate) synthetase

1980

Shane, B.

J. Biol. Chem.

255

5655-5662

1081

6548641

Mammalian folyl polyglutamate synthetase: Partial purification and properties of the mouse liver enzyme

1984

Moran, R.G.; Colman, P.D.

Biochemistry

23

4580-4589

1089

9250977

Human cytosolic folylpoly-gamma-glutamate synthase

1997

Atkinson, I.; Garrow, T.; Brenner, A.; Shane, B.

Methods Enzymol.

281

134-140

1091

8304201

Purification and general properties of human folylpolyglutamate synthetase

1993

Garrow, T.A.; Shane, B.

Chem. Biol. Pteridines Folates (J. E. Ayling et al eds. ) Plenum Press New York

-

659-662

1312

4084560

A multifunctional protein possessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotide transformylase, and aminoimidazole ribonucleotide synthetase activities in de novo purine biosynthesis

1985

Daubner, S.C.; Schrimsher, J.L.; Schendel, F.J.; Young, M.; Henikoff, S.; Patterson, D.; Stubbe, J.; Benkovic, S.J.

Biochemistry

24

7059-7062

1413

1577812

Carbocyclic substrates for de novo purine biosynthesis. Enantiospecific synthesis and enantiospecificity of enzymatic utilization

1992

Caperelli, C.A.; Liu, D.

J. Biol. Chem.

267

9783-9787

1502

2833195

Cloning and expression in Escherichia coli of the Clostridium thermoaceticum gene encoding thermostable formyltetrahydrofolate synthetase

1988

Lovell, C.R.; Przybyla, A.; Ljungdahl, L.G.

Arch. Microbiol.

149

280-285

1503

3497925

10-Formyltetrahydrofolate synthetase. Evidence for a conformational change in the enzyme upon binding of tetrahydropteroylpolyglutamates

1987

Strong, W.; Joshi, G.; Lura, R.; Muthukumaraswamy, N.; Schirch, V.

J. Biol. Chem.

262

12519-12525

1504

6331513

The effect of nordihydroguaiaretic acid and related lignans on formyltetrahydrofolate synthetase and carboxylesterase

1984

Schegg, K.M.; Welch jr., W.

Biochim. Biophys. Acta

788

167-180

1505

6990198

Formyl-methenyl-methylenetetrahydrofolate synthetase (combined): a multifunctional protein in eukaryotic folate metabolism

1980

Paukert, J.L.; Rabinowitz, J.C.

Methods Enzymol.

66

616-626

1506

7374504

Purification and properties of formyltetrahydrofolate synthetase

1980

Buttlaire, D.H.

Methods Enzymol.

66

585-599

1507

6979975

Chemical modification of cysteine and tyrosine residues in formyltetrahydrofolate synthetase from Clostridium thermoaceticum

1982

Elliott, J.I.; Ljungdahl, L.G.

Arch. Biochem. Biophys.

215

245-252

1508

444533

Carbamyl phosphate-dependent ATP synthesis catalyzed by formyltetrahydrofolate synthetase

1979

Buttlaire, D.H.; Balfe, C.A.; Wendland, M.F.; Himes, R.H.

Biochim. Biophys. Acta

567

453-463

1509

624720

Studies on the mechanism of formyltetrahydrofolate synthetase. The Peptococcus aerogenes enzyme

1978

McGuire, J.J.; Rabinowitz, J.C.

J. Biol. Chem.

253

1079-1085

1510

974116

Renaturation of formyltetrahydrofolate synthetase from urea and guanidinium chloride solution

1976

Garrison, C.K.; Harmony, J.A.K.; Himes, R.H.

Biochim. Biophys. Acta

446

301-309

1511

932026

Formyltetrahydrofolate synthetase-catalyzed formation of ATP from carbamyl phosphate and ADP

1976

Buttlaire, D.H.; Himes, R.H.; Reed, G.H.

J. Biol. Chem.

251

4159-4161

1512

1191644

The monovalent cation-induced association of formyltetrahydrofolate synthetase subunits: a solvent isotope effect

1975

Harmony, J.A.K.; Himes, R.H.; Schowen, R.L.

Biochemistry

14

5379-5386

1513

-

Effects of temperature and ammonium ions on formyltetrahydrofolate synthetase from Clostridium thermoaceticum

1974

Shoaf, W.T.; Neece, S.H.; Ljungdahl, L.G.

Biochim. Biophys. Acta

334

448-458

1514

4809524

Cation- and anion-dependent reassociation of formyltetrahydrofolate synthetase subunits

1974

Harmony, J.A.K.; Shaffer, P.J.; Himes, R.H.

J. Biol. Chem.

249

394-401

1515

5016643

Hydrogen ion-induced reversible inactivation and dissociation of formyltetrahydrofolate synthetase

1972

Buttlaire, D.H.; Hersh, R.T.; Himes, R.H.

J. Biol. Chem.

247

2059-2068

1516

5016638

Formyltetrahydrofolate synthetase. Binding of folate substrates and kinetics of the reverse reaction

1972

Curthoys, N.P.; Rabinowitz, J.C.

J. Biol. Chem.

247

1965-1971

1517

5044034

Photooxidation of formyltetrahydrofolate synthetase in the presence of methylene blue

1972

Mackenzie, R.E.; d¦Ari Straus, L.; Rabinowitz, J.C.

Arch. Biochem. Biophys.

150

421-427

1518

8304211

Enzymes for synthesis of 10-formyltetrahydrofolate in plants. Characterization of a monofunctional 10-formyltetrahydrofolate synthetase and copurification of 5,10-methylenetetrahydrofolate dehydrogenase and 5,10-methenyltetrahydrofolate cyclohydrolase activities

1993

Cossins, E.A.; Kirk, C.D.; Imeson, H.C.; Zheng, L.l.

Adv. Exp. Med. Biol.

338

707-710

1519

1917961

Isolation, characterization, and structural organization of 10-formyltetrahydrofolate synthetase from spinach leaves

1991

Nour, J.M.; Rabinowitz, J.C.

J. Biol. Chem.

266

18363-18369

1520

1644815

Isolation and sequencing of the cDNA coding for spinach 10-formyltetrahydrofolate synthetase

1992

Nour, J.M.; Rabinowitz, J.C.

J. Biol. Chem.

267

16292-16296

1521

8405432

Solvent oxygen is not incorporated into N10-formyltetrahydrofolate in the reaction catalyzed by N10-formyltetrahydrofolate synthetase

1993

Song, S.; Jahansouz, H.; Himes, R.H.

FEBS Lett.

332

150-152

1522

1881876

Expression of active domains of a human folate-dependent trifunctional enzyme in Escherichia coli

1991

Hum, D.W.; MacKenzie, R.E.

Protein Eng.

4

493-500

1523

8443597

Sequence and expression of the gene for N10-formyltetrahydrofolate synthetase from Clostridium cylindrosporum

1993

Rankin, C.A.; Haslam, G.C.; Himes, R.H.

Protein Sci.

2

197-205

1524

8765236

Site-directed mutagenesis of putative catalytic and nucleotide binding sites in N10-formyltetrahydrofolate synthetase

1996

Kounga, K.; Song, S.; Haslam, G.C.; Himes, R.H.

Biochim. Biophys. Acta

1296

112-130

1525

8445641

Crystallization and preliminary crystallographic data for formyltetrahydrofolate synthetase from Clostridium thermoaceticum

1993

Lewinski, K.; Hui, Y.; Jakob, C.G.; Lovell, C.R.; Lebioda, L.

J. Mol. Biol.

229

1153-1156

1526

2548602

Formation and utilization of formyl phosphate by N10-formyltetrahydrofolate synthetase: evidence for formyl phosphate as an intermediate in the reaction

1989

Mejillano, M.R.; Jahansouz, H.; Matsunaga, T.O.; Kenyon, G.L.; Himes, R.H.

Biochemistry

28

5136-5145

1527

2200509

Primary structure of the thermostable formyltetrahydrofolate synthetase from Clostridium thermoaceticum

1990

Lovell, C.R.; Przybyla, A.; Ljungdahl, L.G.

Biochemistry

29

5687-5694

1528

-

The affinity of pea cotyledon 10-formyltetrahydrofolate synthetase for polyglutamate substrates

1994

Kirk, C.D.; Imeson, H.C.; Zheng, L.L.; Cossins, E.A.

Phytochemistry

35

291-296

1529

2514800

In vitro conversion of formate to serine: effect of tetrahydropteroylpolyglutamates and serine hydroxymethyltransferase on the rate of 10-formyltetrahydrofolate synthetase

1989

Strong, W.B.; Schirch, V.

Biochemistry

28

9430-9439

1530

3257484

Distribution of 10-formyltetrahydrofolate synthetase in eubacteria

1988

Whitehead, T.R.; Park, M.; Rabinowitz, J.C.

J. Bacteriol.

170

995-997

1531

9061796

Purification, crystallization, and preliminary X-ray studies of 10-formyltetrahydrofolate synthetase from Clostridia acidi-urici

1997

D¦Ari, L.; Cheung, E.; Rabinowitz, J.C.; Bolduc, J.M.; Huang, J.Y.; Stoddard, B.L.

Proteins Struct. Funct. Genet.

27

319-321

172161

7947835

5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRF-CEM leukemia cells: purification, pH dependence and inhibitors

1994

Szabados, E.; Hindmarsh, E.J.; Phillips, L.; Duggleby, R.G.; Christopherson, R.I.

Biochemistry

33

14237-14245

172163

8567683

The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping

1996

Rayl, E.A.; Moroson, B.A.; Beardsley, G.P.

J. Biol. Chem.

271

2225-2233

172166

7354066

Purification of a complex catalizing folate cofactor synthesis and transformylation in de novo purine biosynthesis

1980

Caperelli, C.A.; Benkovic, P.A.; Chettur, G.; Benkovic, S.J

J. Biol. Chem.

255

1885-1890

208967

-

Enzymatic deacylation of N10-formyltetrahydrofolic acid

1957

Huennekens, F.M.

Fed. Proc.

16

199

208968

7868604

Formyltetrahydrofolate hydrolase, a regulatory enzyme that functions to balance pools of tetrahydrofolate and one-carbon tetrahydrofolate adducts in Escherichia coli

1995

Nagy, P.L.; Marolewski, A.; Benkovic, S.J.; Zalkin, H.

J. Bacteriol.

3

1292-1298

209719

3702702

Purification of 5,10-methenyltetrahydrofolate cyclohydrolase from Clostridium formicoaceticum

1986

Ljungdahl, L.G.; Clark, J.E.

Methods Enzymol.

122

385-391

209722

-

5,10-Methenyltetrahydrofolate cyclohydrolase and 5-formyltetrahydrofolate cyclodehydrase in Aedes aegypti

1980

Jaffe, J.J.; Chrin, L.R.; Smith, R.B.

Comp. Biochem. Physiol. B

66

597-600

209726

23838

Methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase from porcine liver. Interaction between the dehydrogenase and cyclohydrolase activities of the multifunctional enzyme

1978

Cohen, L.; MacKenzie, R.E.

Biochim. Biophys. Acta

522

311-317

209728

-

The occurrence and properties of methenyltetrahydrofolate cyclohydrolase in plants

1973

Suzuki, N.; Iwai, K.

Plant Cell Physiol.

14

319-327

392307

350870

A complex of N5,N10-methylenetetrahydrofolate dehydrogenase and N5,N10-methenyltetrahydrofolate cyclohydrolase in Escherichia coli. Purification, subunit structure, and allosteric inhibition by N10-formyltetrahydrofolate

1978

Dev, I.K.; Harvey, R.J.

J. Biol. Chem.

253

4245-4253

392308

1108614

Regulation in the folate pathway of Escherichia coli

1975

Harvey, R.J.; Dev, I.K.

Adv. Enzyme Regul.

13

99-124

392333

9454603

Methenyltetrahydrofolate cyclohydrolase is rate limiting for the enzymatic conversion of 10-formyltetrahydrofolate to 5,10-methylenetetrahydrofolate in bifunctional dehydrogenase-cyclohydrolase enzymes

1998

Pawelek, P.D.; MacKenzie, R.E.

Biochemistry

37

1109-1115

392335

-

10-Formyl tetrahydrofolate:NADP oxidoreductase

1971

Kutzbach, C.; Stokstad, E.L.R.

Methods Enzymol.

18B

793-798

392336

3392008

Resolution of rat liver 10-formyltetrahydrofolate dehydrogenase/hydrolase activities

1988

Case, G.L.; Kaisaki, P.J.; Steele, R.D.

J. Biol. Chem.

263

10204-10207

392337

3697368

Formyltetrahydrofolate dehydrogenase-hydrolase from pig liver: simultaneous assay of the activities

1986

Rios-Orlandi, E.M.; Zarkadas, C.G.; MacKenzie, R.E.

Biochim. Biophys. Acta

871

24-35

392338

4384443

Partial purification of a 10-formyl-tetrahydrofolate: NADP oxidoreductase from mammalian liver

1968

Kutzbach, C.; Stokstad, E.L.R.

Biochem. Biophys. Res. Commun.

30

111-117

392339

3196754

Identification of 10-formyltetrahydrofolate dehydrogenase-hydrolase as a major folate binding protein in liver cytosol

1988

Min, H.; Shane, B.; Stokstad, E.L.R.

Biochim. Biophys. Acta

967

348-353

392340

2733692

Studies on the mechanism of methanol poisoning: purification and comparison of rat and human liver 10-formyltetrahydrofolate dehydrogenase

1989

Johlin, F.C.; Swain, E.; Smith, C.; Tephly, T.R.

Mol. Pharmacol.

35

745-750

392341

36073

Inhibitory effects of histidine and their reversal. The roles of pyruvate carboxylase and N10-formyltetrahydrofolate dehydrogenase

1979

Scrutton, M.C.; Beis, I.

Biochem. J.

177

833-846

392342

7646059

Enzymatic activities of rat liver cytosol 10-formyltetrahydrofolate dehydrogenase

1995

Cook, R.J.; Wagner, C.

Arch. Biochem. Biophys.

321

336-344

392343

7840609

10-Formyltetrahydrofolate dehydrogenase: Identification of the natural folate ligand, covalent labeling, and partial tryptic digestion

1995

Wagner, C.; Briggs, W.T.; Horne, D.H.; Cook, R.J.

Arch. Biochem. Biophys.

316

141-147

392344

7929148

Domain structure and function of 10-formyltetrahydrofolate dehydrogenase

1994

Schirch, D.; Villar, E.; Maras, B.; Barra, D.; Schirch, V.

J. Biol. Chem.

269

24728-24735

392345

10585460

Aspartate 142 is involved in both hydrolase and dehydrogenase catalytic centers of 10-formyltetrahydrofolate dehydrogenase

1999

Krupenko, S.A.; Wagner, C.

J. Biol. Chem.

274

35777-35784

392346

11320079

On the role of conserved histidine 106 in 10-formyltetrahydrofolate dehydrogenase catalysis

2001

Krupenko, S.A.; Vlasov, A.P.; Wagner, C.

J. Biol. Chem.

276

24030-24037

392347

9758763

Overexpression of functional hydrolase domain of rat liver 10-formyltetrahydrofolate dehydrogenase in Escherichia coli

1998

Krupenko, S.A.; Wagner, C.

Protein Expr. Purif.

14

146-152

392348

10204077

Isolation and characterization of cDNA clone for human liver 10-formyltetrahydrofolate dehydrogenase

1999

Hong, M.; Lee, Y.; Kim, J.W.; Lim, J.S.; Chang, S.Y.; Lee, K.S.; Paik, S.G.; Choe, I.S.

Biochem. Mol. Biol. Int.

47

407-415

392349

8961940

Properties of tetrahydropteroylpentaglutamate bound to 10-formyltetrahydrofolate dehydrogenase

1996

Kim, D.W.; Huang, T.; Schirch, D.; Schirch, V.

Biochemistry

35

15772-15783

392350

12065246

10-Formyltetrahydrofolate dehydrogenase, one of the major folate enzymes, is down-regulated in tumor tissues and possesses suppressor effects on cancer cells

2002

Krupenko, S.A.; Oleinik, N.V.

Cell Growth Differ.

13

227-236

392351

-

Recombinant 10-formyltetrahydrofolate dehydrogenase catalyses both dehydrogenase and hydrolase reactions utilizing the synthetic substrate 10-formyl-5,8-dideazafolate

1995

Krupenko, S.A.; Wagner, C.; Cook, R.J.

Biochem. J.

306

651-655

392352

9765265

Identification of protein-arginine N-methyltransferase as 10-formyltetrahydrofolate dehydrogenase

1998

Kim, S.; Park, G.H.; Joo, W.A.; Paik, W.K.; Cook, R.J.; Williams, K.R.

J. Biol. Chem.

273

27374-27382

392353

7822273

Cysteine 707 is involved in the dehydrogenase active site of rat 10-formyltetrahydrofolate dehydrogenase

1995

Krupenko, S.A.; Wagner, C.; Cook, R.J.

J. Biol. Chem.

270

519-522

392354

7972060

Identification of a heritable deficiency of the folate-dependent enzyme 10-formyltetrahydrofolate dehydrogenase in mice

1994

Champion, K.M.; Cook, R.J.; Tollaksen, S.L.; Giometti, C.S.

Proc. Natl. Acad. Sci. USA

91

11338-11342

392355

8975761

Folate and 10-formyltetrahydrofolate dehydrogenase in human and rat retina: Relation to methanol toxicity

1996

Martinasevic, M.K.; Green, M.D.; Baron, J.; Tephly, T.R.

Toxicol. Appl. Pharmacol.

141

373-381

485398

1989499

Inhibition of mammalian thymidylate synthase by 10-formyltetrahydropteroylpolyglutamate

1991

Balinska, M.; Rhee, M.; Whiteley, J.M.; Priest, D.G.; Galivan, J.

Arch. Biochem. Biophys.

284

219-222

485711

-

Purification of mammalian glycinamide ribonucleotide (GAR) synthetase

1986

Hards, R.G.; Graw, S.L.; Patterson, D.

Adv. Exp. Med. Biol.

195

315-319

485712

-

Purification of glycineamide ribonucleotide transformylase

1979

Caperelli, C.A.; Chettur, G.; Lin-Kosley, L.

Dev. Biochem.

4

371-376

485713

13502326

Biosynthesis of the purines. XIX. 2-Amino-N-ribosylacetamide 5'-phosphate(glycinamide ribotide) transformylase

1957

Warren, L.; Buchanan, J.M.

J. Biol. Chem.

229

613-626

485714

7284307

L(-)-10-formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver

1981

Smith, G.K.; Benkovic, P.A.; Benkovic, S.J.

Biochemistry

20

4034-4036

485715

1522592

Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution

1992

Chen, P.; Schulze-Gahmen, U.; Stura, E.A.; Inglese, J.; Johnson, D.L.; Marolewski, A.; Benkovic, S.J.; Wilson, I.A.

J. Mol. Biol.

227

283-292

485716

666851

Purification of glycineamide ribonucleotide transformylase

1978

Caperelli, C.A.; Chettur, G.; Lin, L.Y.; Benkovic, S.J.

Biochem. Biophys. Res. Commun.

82

403-410

485717

3395127

Carbocyclic glycinamide ribonucleotide is a substrate for glycinamide ribonucleotide transformylase

1988

Caperelli, C.A.; Price, M.F.

Arch. Biochem. Biophys.

264

340-342

485718

2185839

Subcloning, characterization, and affinity labeling of Escherichia coli glycinamide ribonucleotide transformylase

1990

Inglese, J.; Johnson, D.L.; Shiau, A.; Smith, J.M.; Benkovic, S.J.

Biochemistry

29

1436-1443

485719

1631098

Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase

1992

Almassy, R.J.; Janson, C.A.; Kann, C.C.; Hostomska, Z.

Proc. Natl. Acad. Sci. USA

89

6114-6118

485720

2656702

Preliminary crystallographic investigations of glycinamide ribonucleotide transformylase

1989

Stura, E.A.; Johnson, D.L; Inglese, J.; Smith, J.M.; Benkovic, S.J.; Wilson, I.A.

J. Biol. Chem.

264

9703-9706

485721

6386041

An antibody probe to determine the native species of glycinamide ribonucleotide transformylase in chicken liver

1984

Young, M.; Sammons, R.D.; Mueller, W.T.; Benkovic, S.J.

Biochemistry

23

3979-3986

485724

3986180

Mammalian glycinamide ribonucleotide transformylase: Purification and some properties

1985

Caperelli, C.A.

Biochemistry

24

1316-1320

485725

2925682

Mammalian glycinamide ribonucleotide transformylase. Kinetic mechanism and associated de novo purine biosynthesis activities

1989

Caperelli, C.A.

J. Biol. Chem.

264

5053-5057

485727

350869

N10-Formyltetrahydrofolate is the formyl donor for glycinamide ribonucleotide transformylase in Escherichia coli

1978

Dev, I.K.; Harvey, R.J.

J. Biol. Chem.

253

4242-4244

485728

7417406

Characterization of the enzyme complex involving the folate-requiring enzymes of de novo purine biosynthesis

1980

Smith, G.K.; Mueller, W.T.; Wasserman, G.F.; Taylor, W.D.; Benkovic, S.J.

Biochemistry

19

4313-4321

485729

8688421

A rapid screen of active site mutants in glycinamide ribonucleotide transformylase

1996

Warren, M.S.; Marolewski, A.E.; Benkovic, S.J.

Biochemistry

35

8855-8862

485730

11352469

The unexpected catalytic properties of a heterodimer of GAR transformylase

2000

Liu, C.; Shim, J.H.; Benkovic, S.J.

Bioorg. Chem.

28

316-323

485731

9265631

Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonucleotide formyltransferase

1997

Sanghani, S.P.; Moran, R.G.

Biochemistry

36

10506-10516

485732

8117714

Cloning and characterization of a new purine biosynthetic enzyme: a non-folate glycinamide ribonucleotide transformylase from E. coli

1994

Marolewski, A.; Smith, J.M.; Benkovic, S.J.

Biochemistry

33

2531-2537

485733

10835105

Improvement in the efficiency of formyl transfer of a GAR transformylase hybrid enzyme

2000

Nixon, A.E.; Benkovic, S.J.

Protein Eng.

13

323-327

485734

9143358

The human glycinamide ribonucleotide transformylase domain: purification, characterization, and kinetic mechanism

1997

Caperelli, C.A.; Giroux, E.L.

Arch. Biochem. Biophys.

341

98-103

485735

10577357

Substrate specificity of human glycinamide ribonucleotide transformylase

1999

Antle, V.D.; Donat, N.; Hua, M.; Liao, P.L.; Vince, R.; Caperelli, C.A.

Arch. Biochem. Biophys.

370

231-235

485736

11390682

Involvement of a transformylase enzyme in siderophore synthesis in Pseudomonas aeruginosa

2001

McMorran, B.J.; Kumara, H.M.C.S.; Sullivan, K.; Lamont, I.L.

Microbiology

147

1517-1524

485737

8313357

A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors

1994

Habeck, L.L.; Leitner, T.A.; Shackelford, K.A.; Gossett, L.S.; Schultz, R.M.; Andis, S.L.; Shih, C.; Grindey, G.B.; Mendelsohn, L.G.

Cancer Res.

54

1021-1026

485738

8626389

Substrate specificity of glycinamide ribonucleotide transformylase from chicken liver

1996

Antle, V.D.; Liu, D.; McKellar, B.R.; Caperelli, C.A.; Hua, M.; Vince, R.

J. Biol. Chem.

271

6045-6049

485739

9628739

Evaluation of the kinetic mechanism of Escherichia coli glycinamide ribonucleotide transformylase

1998

Shim, J.H.; Benkovic, S.J.

Biochemistry

37

8776-8782

485740

11381136

Localization of GAR transformylase in Escherichia coli and mammalian cells

2001

Gooljarsingh, L.T.; Ramcharan, J.; Gilroy, S.; Benkovic, S.J.

Proc. Natl. Acad. Sci. USA

98

6565-6570

485741

10433709

Evaluation of the kinetic mechanism of Escherichia coli glycinamide ribonucleotide transformylase probed by site-directed mutagenesis and pH-dependent studies

1999

Shim, J.H.; Benkovic, S.J.

Biochemistry

38

10024-10031

485742

13672969

Biosynthesis of the purines. XXVI. The Identification of the formyl donors of the transformylation reactions

1959

Hartman, S.C.; Buchanan, J.M.

J. Biol. Chem.

234

1812-1816

485744

4945791

Specificity of 4-aminoimidazole-5-carboxamide ribotide transformylase of Escherichia coli

1971

Patrick, T.W.; Crosbie, G.W.

Biochem. J.

124

31-32

485745

-

The accumulation of 5'-phosphoribosyl-5amino-4-imidazolecarboxamide in folate-deficient pea seedlings and the enzymatic reaction in which the compound is involved

1972

Iwai, K.; Fujisawa, Y.; Suzuki, N.

Agric. Biol. Chem.

36

398-408

485746

-

Folylpoly-gamma-glutamates as cosubstrates of 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide formyltransferase

1979

Baggott, J.E.; Krumdieck, C.L.

Biochemistry

18

1037-1041

485747

7470484

On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver

1981

Mueller, W.T.; Benkovic, S.J.

Biochemistry

20

337-344

485748

7225325

On the cofactor specificity of glycinamide ribonucleotide and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase from chicken liver

1981

Smith, G.K.; Mueller, T.; Benkovic, P.A.; Benkovic, S.J.

Biochemistry

20

1241-1245

485749

2431676

Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide

1986

Baggott, J.E.; Vaughn, W.H.; Hudson, B.B.

Biochem. J.

236

193-200

485750

2268263

Detection of inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase by thioinosinic acid and azathioprine by a new colorimetric assay

1990

Ha, T.; Morgan, S.L.; Vaughn, W.H; Eto, I.; Baggott, J.E.

Biochem. J.

272

339-342

485753

9354238

Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase

1997

Boger, D.L.; Haynes, N.E.; Warren, M.S.; Gooljarsingh, L.T.; Ramcharan, J.; Kitos, P.A.; Benkovic, S.J.

Bioorg. Med. Chem.

5

1831-1838

485754

9378707

Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase

1997

Sugita, T.; Aya, H.; Ueno, M.; Ishizuka, T.; Kawashima, K.

J. Biochem.

122

309-313

485755

-

Crystallization and preliminary crystallographic investigations of avian 5-aminoimidazole-4-carboxamide ribonucleotide transformylase-inosine monophosphate cyclohydrolase expressed in Escherichia coli

2000

Reyes, V.M.; Greasley, S.E.; Stura, E.A.; Beardsley, G.P.; Wilson, I.A.

Acta Crystallogr. Sect. D

56

1051-1054

485756

10985775

Human AICAR transformylase: Role of the 4-Carboxamide of AICAR in binding and catalysis

2000

Wall, M.; Shim, J.H.; Benkovic, S.J.

Biochemistry

39

11303-11311

485757

11457277

Evaluation of the catalytic mechanism of AICAR transformylase by pH-dependent kinetics, mutagenesis, and quantum chemical calculations

2001

Shim, J.H.; Wall, M.; Benkovic, S.J.; Diaz, N.; Suarez, D.; Merz, K.M., Jr.

J. Am. Chem. Soc.

123

4687-4696

485758

11096114

Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity

2001

Vergis, J.M.; Bulock, K.G.; Fleming, K.G.; Beardsley, G.P.

J. Biol. Chem.

276

7727-7733

485759

11948179

The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase): A surprising lack of substrate channeling

2002

Bulock, K.G.; Beardsley, G.P.; Anderson, K.S.

J. Biol. Chem.

277

22168-22174

485760

12501179

Structural insights into the avian AICAR transformylase mechanism

2002

Wolan, D.W.; Greasley, S.E.; Beardsley, G.P.; Wilson, I.A.

Biochemistry

41

15505-15513

485794

5337045

Methionyl soluble ribonucleic acid transformylase. I. Purification and partial characterization

1967

Dickerman, H.W.; Steers, E.; Redfield, B.G.; Weissbach, H.

J. Biol. Chem.

242

1522-1525

485795

6387369

Properties and specificity of methionyl-tRNAfMet formyltransferase from Escherichia coli

1984

Blanquet, S.; Dessen, P.; Kahn, D.

Methods Enzymol.

106

141-152

485796

4573437

Formylation of mischarged E. coli tRNA Met f

1973

Giege, R.; Ebel, J.P.; Clarke, B.F.C.

FEBS Lett.

30

291-295

485797

6989606

Methionyl-transfer-RNA transformylase from Escherichia coli. Purification and characterisation

1980

Kahn, D.; Fromant, M.; Fayat, G.; Dessen, P.; Blanquet, S.

Eur. J. Biochem.

105

489-497

485798

1373194

Nucleotides of tRNA governing the specificity of Escherichia coli methionyl-tRNA(fMet) formyltransferase

1992

Guillon, J.M.; Meinnel, T.; Mechulam, Y.; Lazennec, C.; Blanquet, S.; Fayat, G.

J. Mol. Biol.

224

359-367

485799

1917939

Structural and sequence elements important for recognition of Escherichia coli formylmethionine tRNA by methionyl-tRNA transformylase are clustered in the acceptor stem

1991

Lee, C.P.; Seong, B.L.; RajBhandary, U.L.

J. Biol. Chem.

266

18012-18017

485800

407934

Eukaryotic N10-formyl-H4folate:methionyl-tRNAf transformylase. Some properties of the Euglena gracilis enzyme

1977

Crosti, P.; Gambini, A.; Lucchini, G.; Bianchetti, R.

Biochim. Biophys. Acta

477

356-370

485801

6769490

Inhibitor studies of methionyl-tRNA transformylase of Euglena gracilis

1980

Gambini, A.; Crosti, P.; Bianchetti, R.

Biochim. Biophys. Acta

613

73-78

485802

4206871

Initiation of protein synthesis by folate-sufficient and folate-deficient Streptococcus faecalis R: Partial purification and properties of methionyl-transfer ribonucleic acid synthetase and methionyl-transfer ribonucleic acid formyltransferase

1974

Samuel, C.E.; Rabinowitz, J.C.

J. Bacteriol.

118

21-31

485804

5544683

N-formylmethionyl-tRNA of wheat chloroplasts. Its synthesis by a wheat transformylase

1971

Leis, J.P.; Keller, E.B.

Biochemistry

10

889-894

485805

9843487

Crystal structure of methionyl-tRNAfMet transformylase complexed with the initiator formyl-methionyl-tRNA

1998

Schmitt, E.; Panvert, M.; Blanquet, S.; Mechulam, Y.

EMBO J.

17

6819-6826

485806

8887566

Structure of crystalline Escherichia coli methionyl-tRNAMet formyltransferase: Comparison with glycinamide ribonucleotide formyltransferase

1996

Schmitt, E.; Blanquet, S.; Mechulam, Y.

EMBO J.

15

4749-4758

485807

9832609

Expression and characterization of bovine mitochondrial methionyl-tRNA transformylase

1998

Takeuchi, N.; Ueda, T.; Watanabe, K.

J. Biochem.

124

1069-1071

485808

11274157

Recognition of tRNAs by methionyl-tRNA transformylase from mammalian mitochondria

2001

Takeuchi, N.; Vial, L.; Panvert, M.; Schmitt, E.; Watanabe, K.; Mechulam, Y.; Blanquet, S.

J. Biol. Chem.

276

20064-20068

485809

9391059

Suppressor mutations in Escherichia coli methionyl-tRNA formyltransferase: Role of a 16-amino acid insertion module in initiator tRNA recognition

1997

Ramesh, V.; Gite, S.; Li, Y.; RajBhandary, U.L.

Proc. Natl. Acad. Sci. USA

94

13524-13529

485810

10891086

Suppressor mutations in Escherichia coli methionyl-tRNA formyltransferase that compensate for the formylation defect of a mutant tRNA aminoacylated with lysine

2000

Li, Y.; Ramesh, V.; Mangroo, D.; Taneja, C.; RajBhandary, U.L.

Biochemistry

39

8039-8046

485811

9843398

Functional interaction of an arginine conserved in the sixteen amino acid insertion module of Escherichia coli methionyl-tRNA formyltransferase with determinants for formylation in the initiator tRNA

1998

Ramesh, V.; Gite, S.; RajBhandary, U.L.

Biochemistry

37

15925-15932

485812

10694387

Escherichia coli methionyl-tRNA formyltransferase: Role of amino acids conserved in the linker region and in the C-terminal domain on the specific recognition of the initiator tRNA

2000

Gite, S.; Li, Y.; Ramesh, V.; RajBhandary, U.L.

Biochemistry

39

2218-2226

485813

12549912

Mitochondrial methionyl-tRNAfMet formyltransferase from Saccharomyces cerevisiae: Gene disruption and tRNA substrate specificity

2003

Vial, L.; Gomez, P.; Panvert, M.; Schmitt, E.; Blanquet, S.; Mechulam, Y.

Biochemistry

42

932-939

485814

-

Mapping the active site of the Haemophilus influenzae methionyl-tRNA formyltransferase: Residues important for catalysis and tRNA binding

1999

Newton, D.T.; Mangroo, D.

Biochem. J.

339

63-69

485815

12087168

Conformational change of Escherichia coli initiator methionyl-tRNAfMet upon binding to methionyl-tRNA formyl transferase

2002

Mayer, C.; RajBhandary, U.L.

Nucleic Acids Res.

30

2844-2850

649471

12485612

Site-directed mutagenesis of a potential catalytic and formyl phosphate binding site and substrate inhibition of N10-formyltetrahydrofolate synthetase

2002

Leaphart, A.B.; Trent Spencer, H.; Lovell, C.R.

Arch. Biochem. Biophys.

408

137-143

649939

11087401

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica

2000

Radfar, R.; Leaphart, A.; Brewer, J.M.; Minor, W.; Odom, J.D.; Dunlap, R.B.; Lovell, C.R.; Lebioda, L.

Biochemistry

39

14481-14486

649968

10747779

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica

2000

Radfar, R.; Shin, R.; Sheldrick, G.M.; Minor, W.; Lovell, C.R.; Odom, J.D.; Dunlap, R.B.; Lebioda, L.

Biochemistry

39

3920-3926

650869

9611072

Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defects

1998

Hol, F.A.; van der Put, N.M.; Geurds, M.P.; Heil, S.G.; Trijbels, F.J.; Hamel, B.C.; Mariman, E.C.; Blom, H.J.

Clin. Genet.

53

119-125

650943

10077699

Folate and folate-dependent enzymes associated with rat CNS development

1999

Martinasevic, M.K.; Rios, G.R.; Miller, M.W.; Tephly, T.R.

Dev. Neurosci.

21

29-35

651414

14597174

Characterization of the rat cytoplasmic C1-tetrahydrofolate synthase gene and analysis of its expression in liver regeneration and fetal development

2003

Howard, K.M.; Muga, S.J.; Zhang, L.; Thigpen, A.E.; Appling, D.R.

Gene

319

85-97

651731

14645277

Purification of the formate-tetrahydrofolate ligase from Methylobacterium extorquens AM1 and demonstration of its requirement for methylotrophic growth

2003

Marx, C.J.; Laukel, M.; Vorholt, J.A.; Lidstrom, M.E.

J. Bacteriol.

185

7169-7175

652471

12937168

Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls

2003

Prasannan, P.; Pike, S.; Peng, K.; Shane, B.; Appling, D.R.

J. Biol. Chem.

278

43178-43187

652530

14966129

Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates

2004

Cheong, C.G.; Wolan, D.W.; Greasley, S.E.; Horton, P.A.; Beardsley, G.P.; Wilson, I.A.

J. Biol. Chem.

279

18034-18045

653665

11752472

Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana

2001

Ravanel, S.; Cherest, H.; Jabrin, S.; Grunwald, D.; Surdin-Kerjan, Y.; Douce, R.; Rebeille, F.

Proc. Natl. Acad. Sci. USA

98

15360-15365

654529

12793858

5,10-methenyltetrahydrofolate cyclohydrolase, rat liver and chemically catalysed formation of 5-formyltetrahydrofolate

2003

Baggott, J.E.; MacKenzie, R.E.

Biochem. J.

374

773-778

654797

11004530

Channeling efficiency in the bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase domain: the effects of site-directed mutagenesis of NADP binding residues

2000

Pawelek, P.D.; Allaire, M.; Cygler, M.; MacKenzie, R.E.

Biochim. Biophys. Acta

1479

59-68

656137

12684508

Disruption of a calmodulin central helix-like region of 10-formyltetrahydrofolate dehydrogenase impairs its dehydrogenase activity by uncoupling the functional domains

2003

Reuland, S.N.; Vlasov, A.P.; Krupenko, S.A.

J. Biol. Chem.

278

22894-22900

656770

12805405

Ectopic expression of 10-formyltetrahydrofolate dehydrogenase in A549 cells induces G1 cell cycle arrest and apoptosis

2003

Oleinik, N.V.; Krupenko, S.A.

Mol. Cancer Res.

1

577-588

657946

12974624

Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site

2003

Wolan, D.W.; Greasley, S.E.; Wall, M.J.; Benkovic, S.J.; Wilson, I.A.

Biochemistry

42

10904-10914

657992

12718519

Anticodon sequence mutants of Escherichia coli initiator tRNA: effects of overproduction of aminoacyl-tRNA synthetases, methionyl-tRNA formyltransferase, and initiation factor 2 on activity in initiation

2003

Mayer, C.; Kohrer, C.; Kenny, E.; Prusko, C.; RajBhandary, U.L.

Biochemistry

42

4787-4799

658026

14756554

Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase

2004

Vergis, J.M.; Beardsley, G.P.

Biochemistry

43

1184-1192

658284

15911265

Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization

2005

Capps, K.J.; Humiston, J.; Dominique, R.; Hwang, I.; Boger, D.L.

Bioorg. Med. Chem. Lett.

15

2840-2844

659419

15355974

Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening

2004

Xu, L.; Li, C.; Olson, A.J.; Wilson, I.A.

J. Biol. Chem.

279

50555-50565

659462

15731104

Mitochondrial initiation factor 2 of Trypanosoma brucei binds imported formylated elongator-type tRNA(Met)

2005

Charriere, F.; Tan, T.H.; Schneider, A.

J. Biol. Chem.

280

15659-15665

659681

15615517

Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors

2004

Li, C.; Xu, L.; Wolan, D.W.; Wilson, I.A.; Olson, A.J.

J. Med. Chem.

47

6681-6690

661778

10499278

Recognition of the initiator tRNA by the Pseudomonas aeruginosa methionyl-tRNA formyltransferase: importance of the base-base mismatch at the end of the acceptor stem

1999

Newton, D.T.; Niemkiewicz, M.; Lo, R.Y.; Mangroo, D.

FEMS Microbiol. Lett.

178

289-298

671052

16627949

Mutation of Gly51 to serine in the P-loop of Lactobacillus casei folylpolyglutamate synthetase abolishes activity by altering the conformation of two adjacent loops

2006

Smith, C.A.; Cross, J.A.; Bognar, A.L.; Sun, X.

Acta Crystallogr. Sect. D

62

548-558

673127

17439323

Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis

2007

Gellekink, H.; Blom, H.J.; den Heijer, M.

Clin. Chem. Lab. Med.

45

471-476

673867

17194786

Translation initiation in Saccharomyces cerevisiae mitochondria: functionalinteractions among mitochondrial ribosomal protein Rsm28p, initiation factor 2, methionyl-tRNA-formyltransferase and novel protein Rmd9p

2007

Williams, E.H.; Butler, C.A.; Bonnefoy, N.; Fox, T.D.

Genetics

175

1117-1126

674389

17669278

Rat liver 10-formyltetrahydrofolate dehydrogenase, carbamoyl phosphate synthetase 1 and betaine homocysteine S-methytransferase were co-purified on Kunitz-type soybean trypsin inhibitor-coupled sepharose CL-4B

2007

Kim, H.S.; Kim, J.M.; Roh, K.B.; Lee, H.H.; Kim, S.J.; Shin, Y.H.; Lee, B.L.

J. Biochem. Mol. Biol.

40

604-609

685128

17198385

Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes

2007

Manieri, W.; Moore, M.E.; Soellner, M.B.; Tsang, P.; Caperelli, C.A.

Biochemistry

46

156-163

685138

17302434

Crystal structures of the carboxyl terminal domain of rat 10-formyltetrahydrofolate dehydrogenase: implications for the catalytic mechanism of aldehyde dehydrogenases

2007

Tsybovsky, Y.; Donato, H.; Krupenko, N.I.; Davies, C.; Krupenko, S.A.

Biochemistry

46

2917-2929

687640

17884809

10-formyltetrahydrofolate dehydrogenase requires a 4-phosphopantetheine prosthetic group for catalysis

2007

Donato, H.; Krupenko, N.I.; Tsybovsky, Y.; Krupenko, S.A.

J. Biol. Chem.

282

34159-34166

688289

18680275

Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity

2008

Deng, Y.; Wang, Y.; Cherian, C.; Hou, Z.; Buck, S.A.; Matherly, L.H.; Gangjee, A.

J. Med. Chem.

51

5052-5063

688291

18686942

Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase

2008

DeMartino, J.K.; Hwang, I.; Connelly, S.; Wilson, I.A.; Boger, D.L.

J. Med. Chem.

51

5441-5448

689976

18260100

Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 ANG. resolution

2008

Axelrod, H.L.; McMullan, D.; Krishna, S.S.; Miller, M.D.; Elsliger, M.; Abdubek, P.; Ambing, E.; Astakhova, T.; Carlton, D.; Chiu, H.; Clayton, T.; Duan, L.; Feuerhelm, J.; Grzechnik, S.K.; Hale, J.; Han, G.W.; Haugen, J.; Jaroszewski, L.; Jin, K.K.; Klock, H.E.; Knuth, M.W.; Koesema, E.; Morse, A.T.; Nigoghossian, E.; Okach, L.; Oommachen, S.; Paulsen, J.; Quijano, K.; Reyes, R.; Rife, C.L.; van den Bedem, H.; Weekes, D.; White, A.; Wolf, G.; Xu, Q.; Hodgson, K.O.; Wooley, J.; Deacon. A.M.; Godzik, A.; Lesley, S.A.; Wilson, I.A.

Proteins Struct. Funct. Bioinform.

71

1042-1049

696208

15807526

Crystal structure and mechanism of the Escherichia coli ArnA (PmrI) transformylase domain. An enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance

2005

Gatzeva-Topalova, P.Z.; May, A.P.; Sousa, M.C.

Biochemistry

44

5328-5338

698723

11706007

Oxidative decarboxylation of UDP-glucuronic acid in extracts of polymyxin-resistant Escherichia coli. Origin of lipid a species modified with 4-amino-4-deoxy-L-arabinose

2001

Breazeale, S.D.; Ribeiro, A.A.; Raetz, C.R.

J. Biol. Chem.

277

2886-2896

698730

15695810

A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose

2005

Breazeale, S.D.; Ribeiro, A.A.; McClerren, A.L.; Raetz, C.R.

J. Biol. Chem.

280

14154-14167

698732

15809294

Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis

2005

Williams, G.J.; Breazeale, S.D.; Raetz. C.R.; Naismith. J.H.

J. Biol. Chem.

280

23000-23008

702155

19174154

Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-D,L-4-methyleneglutamic acid (CH-1504) and its analogs

2009

McGuire, J.J.; Haile, W.H.

Biochem. Pharmacol.

77

1161-1172

713460

20381623

Zebrafish 10-formyltetrahydrofolate dehydrogenase is similar to its mammalian isozymes for its structural and catalytic properties

2010

Chang, W.N.; Lin, H.C.; Fu, T.F.

Protein Expr. Purif.

72

217-222

718506

22139174

Expression, purification, crystallization and preliminary X-ray diffraction crystallographic study of PurH from Escherichia coli

2011

Qiu, X.; Yuan, Y.; Gao, Y.

Acta Crystallogr. Sect. F

67

1590-1594

719239

21907147

Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation

2011

Tucker, E.J.; Hershman, S.G.; Koehrer, C.; Belcher-Timme, C.A.; Patel, J.; Goldberger, O.A.; Christodoulou, J.; Silberstein, J.M.; McKenzie, M.; Ryan, M.T.; Compton, A.G.; Jaffe, J.D.; Carr, S.A.; Calvo, S.E.; RajBhandary, U.L.; Thorburn, D.R.; Mootha, V.K.

Cell Metab.

14

428-434

719415

20404044

Evidence for the hypothesis that 10-formyldihydrofolate is the in vivo substrate for aminoimidazolecarboxamide ribotide transformylase

2010

Baggott, J.E.; Tamura, T.

Exp. Biol. Med. (Maywood)

235

271-277

720491

20374492

Mitochondrial translation in absence of local tRNA aminoacylation and methionyl tRNA Met formylation in Apicomplexa

2010

Pino, P.; Aeby, E.; Foth, B.J.; Sheiner, L.; Soldati, T.; Schneider, A.; Soldati-Favre, D.

Mol. Microbiol.

76

706-718

724712

21238436

Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase

2011

Strickland, K.C.; Krupenko, N.I.; Dubard, M.E.; Hu, C.J.; Tsybovsky, Y.; Krupenko, S.A.

Chem. Biol. Interact.

191

129-136

735441

23571548

Staphylococcus aureus formyl-methionyl transferase mutants demonstrate reduced virulence factor production and pathogenicity

2013

Lewandowski, T.; Huang, J.; Fan, F.; Rogers, S.; Gentry, D.; Holland, R.; Demarsh, P.; Aubart, K.; Zalacain, M.

Antimicrob. Agents Chemother.

57

2929-2936

735672

23869564

Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase

2013

Connelly, S.; DeMartino, J.K.; Boger, D.L.; Wilson, I.A.

Biochemistry

52

5133-5144

736461

25288793

Biochemical characterization of pathogenic mutations in human mitochondrial methionyl-tRNA formyltransferase

2014

Sinha, A.; Koehrer, C.; Weber, M.H.; Masuda, I.; Mootha, V.K.; Hou, Y.M.; RajBhandary, U.L.

J. Biol. Chem.

289

32729-32741

736802

25687571

The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network

2015

Boutchueng-Djidjou, M.; Collard-Simard, G.; Fortier, S.; Hebert, S.S.; Kelly, I.; Landry, C.R.; Faure, R.L.

Mol. Cell. Proteomics

14

1079-1092

756039

27439469

Structural and enzymatic analysis of tumor-targeted antifolates that inhibit glycinamide ribonucleotide formyltransferase

2016

Deis, S.M.; Doshi, A.; Hou, Z.; Matherly, L.H.; Gangjee, A.; Dann, C.E.

Biochemistry

55

4574-4582

756109

29042184

Analysis of substrate binding in individual active sites of bifunctional human ATIC

2018

Witkowska, D.; Cox, H.L.; Hall, T.C.; Wildsmith, G.C.; Machin, D.C.; Webb, M.E.

Biochim. Biophys. Acta

1866

254-263

756196

26588576

Colocalization and sequential enzyme activity in aqueous biphasic systems experiments and modeling

2015

Davis, B.W.; Aumiller, W.M.; Hashemian, N.; An, S.; Armaou, A.; Keating, C.D.

Biophys. J.

109

2182-2194

756643

27017552

Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of TS and AICARFTase and as potential antitumor agents

2016

Liu, Y.; Li, M.; Zhang, H.; Yuan, J.; Zhang, C.; Zhang, K.; Guo, H.; Zhao, L.; Du, Y.; Wang, L.; Ren, L.

Eur. J. Med. Chem.

115

245-256

756648

28830032

Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase

2017

Xing, R.; Zhang, H.; Yuan, J.; Zhang, K.; Li, L.; Guo, H.; Zhao, L.; Zhang, C.; Li, S.; Gao, T.; Liu, Y.; Wang, L.

Eur. J. Med. Chem.

139

531-541

756701

29063699

Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus lugdunensis

2017

Verma, P.; Kar, B.; Varshney, R.; Roy, P.; Sharma, A.

FEBS J.

284

4233-4261

756708

30767393

Msc6p is required for mitochondrial translation initiation in the absence of formylated Met-tRNAfMet

2019

Franco, L.V.R.; Moda, B.S.; Soares, M.A.K.M.; Barros, M.H.

FEBS J.

286

1407-1419

757016

-

Virtual screening of phytochemicals for methotrexate like dihydrofolate reductase and aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase inhibitory property using Molegro virtual docker

2016

Markandeyan, D.; Kannaiyan, S.; Suresh, S.; Nimmakayala, R.; Ilamurugan, R.; Santhalingam, K.; Paul, B.

Int. J. Pharm. Pharm. Sci.

8

83-87

757213

29414769

High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans

2018

Riedinger, C.; Mendler, M.; Schlotterer, A.; Fleming, T.; Okun, J.; Hammes, H.P.; Herzig, S.; Nawroth, P.P.

J. Biol. Chem.

293

4845-4859

757394

29072452

Discovery of N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a potent and selective nonclassical antifolate aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT) inhibitor

2017

Fales, K.R.; Njoroge, F.G.; Brooks, H.B.; Thibodeaux, S.; Torrado, A.; Si, C.; Toth, J.L.; Mc Cowan, J.R.; Roth, K.D.; Thrasher, K.J.; Frimpong, K.; Lee, M.R.; Dally, R.D.; Shepherd, T.A.; Durham, T.B.; Margolis, B.J.; Wu, Z.; Wang, Y.; Atwell, S.; Wang, J.; Hui, Y.H.; Meier, T.I.; Konicek, S.A.; Geeganage, S.

J. Med. Chem.

60

9599-9616

757625

29799386

Utilisation of 10-formyldihydrofolate as substrate by dihydrofolate reductase (DHFR) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) tranformylase/IMP cyclohydrolase (PurH) in Escherichia coli

2018

Sah, S.; Shah, R.; Govindan, A.; Varada, R.; Rex, K.; Varshney, U.

Microbiology

164

982-991

757809

28058511

Identification and functional characterization of a novel MTFMT mutation associated with selective vulnerability of the visual pathway and a mild neurological phenotype

2017

La Piana, R.; Weraarpachai, W.; Ospina, L.H.; Tetreault, M.; Majewski, J.; Majewski, J.; Bruce Pike, G.; Decarie, J.C.; Tampieri, D.; Brais, B.; Shoubridge, E.A.

Neurogenetics

18

97-103

758290

27171345

Structure of the Escherichia coli ArnA N-formyltransferase domain in complex with N5-formyltetrahydrofolate and UDP-Ara4N

2016

Genthe, N.A.; Thoden, J.B.; Holden, H.M.

Protein Sci.

25

1555-1562

758344

28855807

In silico analysis of glycinamide ribonucleotide transformylase inhibition by PY873, PY899 and DIA

2017

Batool, S.; Nawaz, M.S.; Mushtaq, G.; Parvaiz, F.; Kamal, M.A.

Saudi J. Biol. Sci.

24

1155-1161

760585

28636341

Biochemical Characterization of WbkC, an N-Formyltransferase from Brucella melitensis

2017

Riegert, A.S.; Chantigian, D.P.; Thoden, J.B.; Tipton, P.A.; Holden, H.M.

Biochemistry

56

3657-3668

762368

11081580

Genetic organisation of the lipopolysaccharide O-antigen biosynthesis region of Brucella melitensis 16M (wbk)

2000

Godfroid, F.; Cloeckaert, A.; Taminiau, B.; Danese, I.; Tibor, A.; De Bolle, X.; Mertens, P.; Letesson, J.

Res. Microbiol.

151

655-668

Links to other databases for 10-formyltetrahydrofolate

top print hide

Show Links (1 entry)

ChEBI

PubChem

-