Ligand 10-formyltetrahydrofolate

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Basic Ligand Information

Molecular Structure
Picture of 10-formyltetrahydrofolate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H23N7O7
10-formyltetrahydrofolate
AUFGTPPARQZWDO-YUZLPWPTSA-N
Synonyms:
(-)-10-formyltetrahydrofolate, (6R,6S)-10-formyltetrahydrofolic acid, (6R,S)-10-formyltetrahydrofolate, 10-formyl-5,6,7,8-tetrahydropteroyl-Glu, 10-formyl-5,6,7,8-tetrahydropteroylglutamate, 10-formyl-tetrahydrofolate, 10-formyl-tetrahydrofolic acid, 10-formyltetrahydropteroylmonoglutamate, L-(-)-10-formyltetrahydrofolate, N10-formyltetrahydrofolate, N10-formyltetrahydropteroylmono-glutamate, N10-formyltetrahydropteroylmonoglutamate


Show all pahtways known for Show all BRENDA pathways known for 10-formyltetrahydrofolate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH + H+
show the reaction diagram
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10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose
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10-formyltetrahydrofolate + GDP-alpha-D-perosamine = tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine
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10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate
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10-formyltetrahydrofolate = 5,10-methenyltetrahydrofolate + H2O
show the reaction diagram
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ADP + phosphate + 10-formyltetrahydrofolate = ?
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
10-formyl-dihydrofolate + NADPH + H+ = 10-formyl-tetrahydrofolate + NADP+
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tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (50 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose
show the reaction diagram
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10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate
show the reaction diagram
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10-formyltetrahydrofolate = 5,10-methenyltetrahydrofolate + H2O
show the reaction diagram
-
ADP + phosphate + 10-formyltetrahydrofolate = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
10-formyl-dihydrofolate + NADPH + H+ = 10-formyl-tetrahydrofolate + NADP+
show the reaction diagram
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ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate
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N5,N10-anhydroformyltetrahydrofolate + glycinamide ribotide + H2O = N10-formyltetrahydrofolate + formylglycinamide ribotide
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tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
4.97
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pH 7.5, temperature not specified in the publication

KM Value (55 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
10
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-

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.07
-
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0.02
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-

References & Links

Links to other databases for 10-formyltetrahydrofolate

ChEBI
PubChem
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PubChem