Ligand homoisocitrate

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Basic Ligand Information

Molecular Structure
Picture of homoisocitrate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C7H10O7
homoisocitrate
OEJZZCGRGVFWHK-WVZVXSGGSA-N
Synonyms:
(-)-1-hydroxy-1,2,4-butanetricarboxylate, (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate, (2R,3S)-homoisocitrate, 1-hydroxy-1,2,4-butanetricarboxylate, 2(R),3(S)-homoisocitrate, 2-hydroxy-3-carboxyadipate, 3-carboxy-2-hydroxyadipate, D-homoisocitrate, homoisocitric acid


Show all pahtways known for Show all BRENDA pathways known for homoisocitrate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-homoisocitrate + NAD+ = ? + NADH
show the reaction diagram
-
homoisocitrate + NAD+ = ? + NADH + H+
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive, pH-dependent substrate inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (27 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
13.7
-
6fold His-tagged enzyme, at 70C in 50 mM N-2-hydroxyethylpiperadine-N0-2-ethanesulfonate-NaOH (pH 7.8), 0.2 M KCl, 0.2 mM MnCl2, 1 mM NAD+
0.26
-
at pH 8.0 and 60C

KM Value (32 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0183
-
6fold His-tagged enzyme, at 70C in 50 mM N-2-hydroxyethylpiperadine-N0-2-ethanesulfonate-NaOH (pH 7.8), 0.2 M KCl, 0.2 mM MnCl2, 1mM NAD+
5.9
-
at pH 8.0 and 60C
1.1
-
-

References & Links

Links to other databases for homoisocitrate

ChEBI
PubChem
ChEBI
PubChem