Ligand palmatine

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Basic Ligand Information

Molecular Structure
Picture of palmatine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H22NO4
palmatine
QUCQEUCGKKTEBI-UHFFFAOYSA-N

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
palmatine + NADPH = ? + NADP+
show the reaction diagram
-
S-adenosyl-L-methionine + palmatine + NADPH + H+ = S-adenosyl-L-homocysteine + corydaline + NADP+
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-tetrahydropalmatine + O2 = palmatine + H2O2
show the reaction diagram
-
-
S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + palmatine
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
irreversible potent IDO-1 inhibitor
-
5 mM, 70% inhibition
-
reversible non-competitive inhibition
-

Enzyme Kinetic Parameters

IC50 Value (3 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0128
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C

References & Links

Links to other databases for palmatine

ChEBI
PubChem
ChEBI
PubChem